Search Results - "Youker, KA"

Inhibitory cardiac transcription factor, SRF-N, is generated by caspase 3 cleavage in human heart failure and attenuated by ventricular unloading by Chang, Jiang, Wei, Lei, Otani, Takayuki, Youker, Keith A, Entman, Mark L, Schwartz, Robert J

“…Knowledge about molecular mechanisms leading to heart failure is still limited, but reduced gene activities and modest activation of caspase 3 are hallmarks of…”
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Is inflammation good for the ischemic heart--perspectives beyond the ordinary by Entman, M L, Youker, K A, Frangogiannis, N, Lakshminarayanan, V, Nossuli, T, Evans, A, Kurrelmeyer, K, Mann, D L, Smith, C W

“…In recent years, early reperfusion of the myocardial infarct has become the mainstay of optimal therapeutic management since it limits ventricular injury and…”
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Tumor necrosis factor-α in the failing human heart: Does it play a role in disease progression? by Torre-Amione, G, Stetson, S, Vooletich, M, Jacobs, V, Youker KA

“…Summary An increasing body of clinical and experimental evidence suggesting that TNFα may play a pathogenetic role in failing hearts continues to accumulate…”
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Impaired Long-Chain Fatty Acid Oxidation and Contractile Dysfunction in the Obese Zucker Rat Heart by YOUNG, Martin E, GUTHRIE, Patrick H, RAZEGHI, Peter, LEIGHTON, Brendan, ABBASI, Shahrzad, PATIL, Sarita, YOUKER, Keith A, TAEGTMEYER, Heinrich

“…Impaired Long-Chain Fatty Acid Oxidation and Contractile Dysfunction in the Obese Zucker Rat Heart Martin E. Young 1 , Patrick H. Guthrie 1 , Peter Razeghi 1 ,…”
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Telomerase Reverse Transcriptase Promotes Cardiac Muscle Cell Proliferation, Hypertrophy, and Survival by Oh, Hidemasa, Taffet, George E., Youker, Keith A., Entman, Mark L., Overbeek, Paul A., Michael, Lloyd H., Schneider, Michael D.

“…Cardiac muscle regeneration after injury is limited by "irreversible" cell cycle exit. Telomere shortening is one postulated basis for replicative senescence,…”
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Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure by Sano, Motoaki, Wang, Sam C, Shirai, Manabu, Scaglia, Fernando, Xie, Min, Sakai, Satoshi, Tanaka, Toru, Kulkarni, Prathit A, Barger, Philip M, Youker, Keith A, Taffet, George E, Hamamori, Yasuo, Michael, Lloyd H, Craigen, William J, Schneider, Michael D

“…Hypertrophy allows the heart to adapt to workload but culminates in later pump failure; how it is achieved remains uncertain. Previously, we showed that…”
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Telomere Attrition and Chk2 Activation in Human Heart Failure by Oh, Hidemasa, Wang, Sam C., Prahash, Arun, Sano, Motoaki, Moravec, Christine S., Taffet, George E., Michael, Lloyd H., Youker, Keith A., Entman, Mark L., Schneider, Michael D.

“…The "postmitotic" phenotype in adult cardiac muscle exhibits similarities to replicative senescence more generally and constitutes a barrier to effective…”
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Resident cardiac mast cells degranulate and release preformed TNF-α, initiating the cytokine cascade in experimental canine myocardial ischemia/reperfusion by FRANGOGIANNIS, N. G, LINDSEY, M. L, MICHAEL, L. H, YOUKER, K. A, BRESSLER, R. B, MENDOZA, L. H, SPENGLER, R. N, SMITH, C. W, ENTMAN, M. L

“…Neutrophil-induced cardiomyocyte injury requires the expression of myocyte intercellular adhesion molecule (ICAM)-1 and ICAM-1-CD11b/CD18 adhesion. We have…”
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Coronary Microembolization: the Role of TNF- α in Contractile Dysfunction by Dörge, Hilmar, Schulz, Rainer, Belosjorow, Sergej, Post, Heiner, van de Sand, Anita, Konietzka, Ina, Frede, Stilla, Hartung, Thomas, Vinten-Johansen, Jakob, Youker, Keith A., Entman, Mark L., Erbel, Raimund, Heusch, Gerd

“…Coronary microembolization is a frequent complication of atherosclerotic plaque rupture in acute coronary syndromes and during coronary interventions…”
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Decreased expression of tumor necrosis factor-α in failing human myocardium after mechanical circulatory support : A potential mechanism for cardiac recovery by TORRE-AMIONE, G, STETSON, S. J, YOUKER, K. A, DURAND, J.-B, RADOVANCEVIC, B, DELGADO, R. M, FRAZIER, O. H, ENTMAN, M. L, NOON, G. P

“…An increasing number of observations in patients with end-stage heart failure suggest that chronic ventricular unloading by mechanical circulatory support may…”
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Cardiac myocytes produce interleukin-6 in culture and in viable border zone of reperfused infarctions by GWECHENBERGER, M, MENDOZA, L. H, YOUKER, K. A, FRANGOGIANNIS, N. G, SMITH, C. W, MICHAEL, L. H, ENTMAN, M. L

“…Previous work from our laboratory demonstrated that interleukin (IL)-6 plays a potentially critical role in postreperfusion myocardial injury and is the major…”
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Organ-specific regulation of pro-inflammatory molecules in heart, lung, and kidney following brain death by Skrabal, Christian A., Thompson, Larry O., Potapov, Evgenji V., Southard, Robert E., Joyce, David L., Youker, Keith A., Noon, George P., Loebe, Matthias

“…Nonspecific inflammatory events following brain death may increase the intensity of the immunological host response. The present study investigated the course…”
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The Role of Mast Cells After Solid Organ Transplantation by JAHANYAR, Jama, KOERNER, Michael M, LOEBE, Matthias, YOUKER, Keith A, TORRE-AMIONE, Guillermo, NOON, George P

“…Mast cells are best known as primary responders in allergic reactions, including anaphylaxis and asthma. However, recent studies have shown that mast cells are…”
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Myocardial ischemia and reperfusion: a murine model by Michael, L H, Entman, M L, Hartley, C J, Youker, K A, Zhu, J, Hall, S R, Hawkins, H K, Berens, K, Ballantyne, C M

“…Myocardial ischemia followed by reperfusion promotes a complex series of inflammatory reactions as noted in a variety of large animal studies. With development…”
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Role of mast cells and their mediators in failing myocardium under mechanical ventricular support by Akgul, Ahmet, Skrabal, Christian A, Thompson, Larry O, Loebe, Matthias, Lafuente, Javier A, Noon, George P, Youker, Keith A

“…Mast cells have been implicated in tissue remodeling and fibroblast stimulation. We explored the effect of mechanical support by left ventricular assist device…”
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Complement C5a, TGF-beta 1, and MCP-1, in sequence, induce migration of monocytes into ischemic canine myocardium within the first one to five hours after reperfusion by Birdsall, H H, Green, D M, Trial, J, Youker, K A, Burns, A R, MacKay, C R, LaRosa, G J, Hawkins, H K, Smith, C W, Michael, L H, Entman, M L, Rossen, R D

“…Recent studies suggest that reperfusion promotes healing of formerly ischemic heart tissue even when myocardial salvage is no longer possible. Since…”
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Induction of interleukin-6 synthesis in the myocardium : potential role in postreperfusion inflammatory injury by KUKIELKA, G. L, SMITH, C. W, MANNING, A. M, YOUKER, K. A, MICHAEL, L. H, ENTMAN, M. L

“…Neutrophil-induced injury of myocardial cells requires the expression of intercellular adhesion molecule-1 (ICAM-1) on the myocyte surface and is mediated by…”
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Cytokines and the Microcirculation in Ischemia and Reperfusion by Frangogiannis, Nikolaos G., Youker, Keith A., Rossen, Roger D., Gwechenberger, Marianne, Lindsey, Merry H., Mendoza, Leonardo H., Michael, Lloyd H., Ballantyne, Christie M., Smith, C.Wayne, Entman, Mark L.

“…The intense inflammatory reaction following reperfusion of the infarcted myocardium has been implicated as a factor in extension of injury. However, this…”
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Plasma neurohormone levels correlate with left ventricular functional and morphological improvement in LVAD patients by THOMPSON, Larry O, SKRABAL, Christian A, YOUKER, Keith A, LOEBE, Matthias, LAFUENTE, Javier A, ROBERTS, Rick R, AKGUL, Ahmet, JONES, Vonne, BRUCKNER, Brian A, THOHAN, Vinay, NOON, George P

“…Brain natriuretic peptide (BNP) and endothelin-1 (ET-1) have been shown to be markers of left ventricular (LV) function. To determine the feasibility of using…”
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Black Bean Extract Inhibits Cardiac Fibrosis and Restores Cardiac Function in an Acute Non-Ischemic Cardiomyopathy Mouse Model by Youker, Keith A, Khalil, Ahmad, Orrego, Carlos, Flores-Arredondo, Jose, Serrano, Sergio, Moreno, Jorge, Torre-Amione, Guillermo

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