Search Results - "You, Inchul"

Discovery and resistance mechanism of a selective CDK12 degrader by Jiang, Baishan, Gao, Yang, Che, Jianwei, Lu, Wenchao, Kaltheuner, Ines H., Dries, Ruben, Kalocsay, Marian, Berberich, Matthew J., Jiang, Jie, You, Inchul, Kwiatkowski, Nicholas, Riching, Kristin M., Daniels, Danette L., Sorger, Peter K., Geyer, Matthias, Zhang, Tinghu, Gray, Nathanael S.

“…Cyclin-dependent kinase 12 (CDK12) is an emerging therapeutic target due to its role in regulating transcription of DNA-damage response (DDR) genes. However,…”
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Down-Regulation of AKT Proteins Slows the Growth of Mutant-KRAS Pancreatic Tumors by Chen, Chuankai, Jiang, Ya-Ping, You, Inchul, Gray, Nathanael S, Lin, Richard Z

“…Serine/threonine kinase AKT isoforms play a well-established role in cell metabolism and growth. Most pancreatic adenocarcinomas (PDACs) harbor activation…”
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Discovery of Potent Degraders of the Dengue Virus Envelope Protein by Li, Zhengnian, Liu, Han‐Yuan, He, Zhixiang, Chakravarty, Antara, Golden, Ryan P., Jiang, Zixuan, You, Inchul, Yue, Hong, Donovan, Katherine A., Du, Guangyan, Che, Jianwei, Tse, Jason, Che, Isaac, Lu, Wenchao, Fischer, Eric S., Zhang, Tinghu, Gray, Nathanael S., Yang, Priscilla L.

“…Targeted protein degradation has been widely adopted as a new approach to eliminate both established and previously recalcitrant therapeutic targets. Here, it…”
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Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling by You, Inchul, Erickson, Emily C, Donovan, Katherine A, Eleuteri, Nicholas A, Fischer, Eric S, Gray, Nathanael S, Toker, Alex

“…The PI3K/AKT signaling cascade is one of the most commonly dysregulated pathways in cancer, with over half of tumors exhibiting aberrant AKT activation…”
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Exploring the Features and Challenges of Proteolysis Targeting Chimera (Protac) Development by You, Inchul

“…Small molecule inhibitors offer a powerful approach to modulate biological systems, having been successfully used as probes to interrogate protein functions…”
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Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development by Donovan, Katherine A., Ferguson, Fleur M., Bushman, Jonathan W., Eleuteri, Nicholas A., Bhunia, Debabrata, Ryu, SeongShick, Tan, Li, Shi, Kun, Yue, Hong, Liu, Xiaoxi, Dobrovolsky, Dennis, Jiang, Baishan, Wang, Jinhua, Hao, Mingfeng, You, Inchul, Teng, Mingxing, Liang, Yanke, Hatcher, John, Li, Zhengnian, Manz, Theresa D., Groendyke, Brian, Hu, Wanyi, Nam, Yunju, Sengupta, Sandip, Cho, Hanna, Shin, Injae, Agius, Michael P., Ghobrial, Irene M., Ma, Michelle W., Che, Jianwei, Buhrlage, Sara J., Sim, Taebo, Gray, Nathanael S., Fischer, Eric S.

“…Targeted protein degradation (TPD) refers to the use of small molecules to induce ubiquitin-dependent degradation of proteins. TPD is of interest in drug…”
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Targeted kinase degradation via the KLHDC2 ubiquitin E3 ligase by Kim, Younghoon, Seo, Pooreum, Jeon, Eunhye, You, Inchul, Hwang, Kyubin, Kim, Namkyoung, Tse, Jason, Bae, Juhyeon, Choi, Ha-Soon, Hinshaw, Stephen M, Gray, Nathanael S, Sim, Taebo

“…Chemically induced protein degradation is a powerful strategy for perturbing cellular biochemistry. The predominant mechanism of action for protein degrader…”
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Exploring the target scope of KEAP1 E3 ligase-based PROTACs by Du, Guangyan, Jiang, Jie, Henning, Nathaniel J, Safaee, Nozhat, Koide, Eriko, Nowak, Radosław P, Donovan, Katherine A, Yoon, Hojong, You, Inchul, Yue, Hong, Eleuteri, Nicholas A, He, Zhixiang, Li, Zhengnian, Huang, Hubert T, Che, Jianwei, Nabet, Behnam, Zhang, Tinghu, Fischer, Eric S, Gray, Nathanael S

“…Targeted protein degradation (TPD) uses small molecules to recruit E3 ubiquitin ligases into the proximity of proteins of interest, inducing…”
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Chemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive Chemistry by Sarott, Roman C., You, Inchul, Li, Yen-Der, Toenjes, Sean T., Donovan, Katherine A., Seo, Pooreum, Ordonez, Martha, Byun, Woong Sub, Hassan, Muhammad Murtaza, Wachter, Franziska, Chouchani, Edward T., Słabicki, Mikołaj, Fischer, Eric S., Ebert, Benjamin L., Hinshaw, Stephen M., Gray, Nathanael S.

“…Targeted protein degradation relies on small molecules that induce new protein–protein interactions between targets and the cellular protein degradation…”
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Discovery of CRBN-Dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library by Razumkov, Hlib, Jiang, Zixuan, Baek, Kheewoong, You, Inchul, Geng, Qixiang, Donovan, Katherine A., Tang, Michelle T., Metivier, Rebecca J., Mageed, Nada, Seo, Pooreum, Li, Zhengnian, Byun, Woong Sub, Hinshaw, Stephen M., Sarott, Roman C., Fischer, Eric S., Gray, Nathanael S.

“…Small molecules promoting protein-protein interactions produce a range of therapeutic outcomes. Molecular glue degraders exemplify this concept due to their…”
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Acute pharmacological degradation of ERK5 does not inhibit cellular immune response or proliferation by You, Inchul, Donovan, Katherine A, Krupnick, Noah M, Boghossian, Andrew S, Rees, Matthew G, Ronan, Melissa M, Roth, Jennifer A, Fischer, Eric S, Wang, Eric S, Gray, Nathanael S

“…Recent interest in the role that extracellular signal-regulated kinase 5 (ERK5) plays in various diseases, particularly cancer and inflammation, has grown…”
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Structure-Based Design of Y‑Shaped Covalent TEAD Inhibitors by Lu, Wenchao, Fan, Mengyang, Ji, Wenzhi, Tse, Jason, You, Inchul, Ficarro, Scott B., Tavares, Isidoro, Che, Jianwei, Kim, Audrey Y., Zhu, Xijun, Boghossian, Andrew, Rees, Matthew G., Ronan, Melissa M., Roth, Jennifer A., Hinshaw, Stephen M., Nabet, Behnam, Corsello, Steven M., Kwiatkowski, Nicholas, Marto, Jarrod A., Zhang, Tinghu, Gray, Nathanael S.

“…Transcriptional enhanced associate domain (TEAD) proteins together with their transcriptional coactivator yes-associated protein (YAP) and transcriptional…”
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Development of a Covalent Inhibitor of c‑Jun N‑Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1 by Lu, Wenchao, Liu, Yao, Gao, Yang, Geng, Qixiang, Gurbani, Deepak, Li, Lianbo, Ficarro, Scott B., Meyer, Cynthia J., Sinha, Dhiraj, You, Inchul, Tse, Jason, He, Zhixiang, Ji, Wenzhi, Che, Jianwei, Kim, Audrey Y., Yu, Tengteng, Wen, Kenneth, Anderson, Kenneth C., Marto, Jarrod A., Westover, Kenneth D., Zhang, Tinghu, Gray, Nathanael S.

“…The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family, which includes JNK1–JNK3. Interestingly, JNK1 and JNK2…”
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Template-assisted covalent modification underlies activity of covalent molecular glues by Li, Yen-Der, Ma, Michelle W, Hassan, Muhammad Murtaza, Hunkeler, Moritz, Teng, Mingxing, Puvar, Kedar, Rutter, Justine C, Lumpkin, Ryan J, Sandoval, Brittany, Jin, Cyrus Y, Schmoker, Anna M, Ficarro, Scott B, Cheong, Hakyung, Metivier, Rebecca J, Wang, Michelle Y, Xu, Shawn, Byun, Woong Sub, Groendyke, Brian J, You, Inchul, Sigua, Logan H, Tavares, Isidoro, Zou, Charles, Tsai, Jonathan M, Park, Paul M C, Yoon, Hojong, Majewski, Felix C, Sperling, Haniya T, Marto, Jarrod A, Qi, Jun, Nowak, Radosław P, Donovan, Katherine A, Słabicki, Mikołaj, Gray, Nathanael S, Fischer, Eric S, Ebert, Benjamin L

“…Molecular glues are proximity-inducing small molecules that have emerged as an attractive therapeutic approach. However, developing molecular glues remains…”
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Redirecting the Neo-Substrate Specificity of Cereblon-Targeting PROTACs to Helios by Verano, Alyssa L., You, Inchul, Donovan, Katherine A., Mageed, Nada, Yue, Hong, Nowak, Radosław P., Fischer, Eric S., Wang, Eric S., Gray, Nathanael S.

“…Immunomodulatory imide drugs (IMiDs), such as thalidomide and its analogues, are some of the most commonly utilized E3 ligase ligands for the development of…”
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Global trends in regulatory frameworks for animal genome editing in agriculture by Dajeong Lim, Inchul Choi

“…Revolutionary advancements, such as the reduction in DNA sequencing costs and genome editing, have transformed biotechnology, fostering progress in…”
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A simple and rapid method for detection of single nucleotide variants using tailed primer and HRM analysis by Hyeonguk Baek, Inchul, Choi

“…Background: Single nucleotide polymorphisms (SNPs) are widely used genetic markers with applications in human disease diagnostics, animal breeding, and…”
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Traf4 is required for tight junction complex during mouse blastocyst formation by Lee, Jian, Choi, Inchul

“…Traf4 (Tumor necrosis factor Receptor Associated Factor 4) is a member of the tumor necrosis factor receptor (TNFR) - associated factors (TRAFs) family. TRAF4…”
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Tight Junction Assembly Ensures Maintenance of Pregnancy during Embryogenesis in a Mouse Model by Jeong, Yelin, Choi, Inchul

“…Recent studies showed that tight junctions (TJs) integrity and assembly are required for blastocyst development in mouse and pig models. However, the…”
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Preliminary analyses on decontamination factors during pool scrubbing with bubble size distributions obtained from EPRI experiments by Lee, Yoonhee, Cho, Yong Jin, Ryu, Inchul

“…In this paper, from a review of the size distribution of the bubbles during pool scrubbing obtained from experiments by EPRI, we apply the bubble size…”
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