Search Results - "Yosu, Vara"

In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma by Pérez-Salvia, Montserrat, Aldaba, Eneko, Vara, Yosu, Fabre, Myriam, Ferrer, Cristina, Masdeu, Carme, Zubia, Aizpea, Sebastian, Eider San, Otaegui, Dorleta, Llinàs-Arias, Pere, Rosselló-Tortella, Margalida, Berdasco, Maria, Moutinho, Catia, Setien, Fernando, Villanueva, Alberto, González-Barca, Eva, Muncunill, Josep, Navarro, José-Tomás, Piris, Miguel A, Cossio, Fernando P, Esteller, Manel

“…Cancer origin and development is associated not only with genetic alterations, but also with the disturbance of epigenetic profiles.1 In this regard, the…”
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Stereocontrolled formation of substituted imidazolidines in the reaction between N-metalated azomethine ylides and isocyanates by Erkizia, Edurne, Aldaba, Eneko, Vara, Yosu, Arrieta, Ana, Gornitzka, Heinz, Cossío, Fernando P.

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Regioselective Preparation of Benzo[b]furans from Phenols and α-Bromoketones by Arias, Leire, Vara, Yosu, Cossío, Fernando P

“…In this paper, a fully regiocontrolled synthesis of either 2- and 3-substituted benzo­[b]­furans is described. Direct reaction between phenols and…”
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Formation of γ-Oxoacids and 1 H -Pyrrol-2(5 H )-ones from α,β-Unsaturated Ketones and Ethyl Nitroacetate by Aginagalde, Maialen, Bello, Tamara, Masdeu, Carme, Vara, Yosu, Arrieta, Ana, Cossío, Fernando P.

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Tandem [8 + 2] Cycloaddition−[2 + 6 + 2] Dehydrogenation Reactions Involving Imidazo[1,2-a]pyridines and Imidazo[1,2-a]pyrimidines by Aginagalde, Maialen, Vara, Yosu, Arrieta, Ana, Zangi, Ronen, Cebolla, Vicente L, Delgado-Camón, Arantzazu, Cossío, Fernando P

“…The reaction between benzynes and imidazo[1,2-a]pyridines (pyrimidines) to form benzo[a]imidazo[5,1,2-cd]indolizines and 2,3,9c-triazocyclopenta[j,k]fluorenes…”
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Abstract 4725: Efficacy of a new small-molecule inhibitor of histone deacetylase 6 (HDAC6) in preclinical models of B-cell lymphoma and acute myeloid leukemia by Villanueva, Lorea, Perez-Salvia, Montserrat, Aldaba, Eneko, Vara, Yosu, Fabre, Myriam, Ferrer, Cristina, Masdeu, Carme, Zubia, Aizpea, Sebastian, Eider San, Otaegui, Dorleta, Llinàs-Arias, Pere, Rosselló-Tortella, Margalida, Berdasco, María, Setien, Fernando, Moutinho, Catia, Villanueva, Alberto, González-Barca, Eva, Muncunill, Josep, Navarro, José Tomás, Piris, Miguel Ángel, Cossio, Fernando, Esteller, Manel

“…Histone deacetylase 6 (HDAC6) is a protein modifier that is an increasingly attractive pharmacological target. Interestingly, the observation that the HDAC6…”
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Formation of γ-Oxoacids and 1H-Pyrrol-2(5H)-ones from α,β-Unsaturated Ketones and Ethyl Nitroacetate by Aginagalde, Maialen, Bello, Tamara, Masdeu, Carme, Vara, Yosu, Arrieta, Ana, Cossío, Fernando P

“…Michael addition of ethyl nitroacetate on α,β-unsaturated ketones followed by Nef oxidation under hydrolytic conditions yields γ-oxoacids instead of the…”
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Efficacy of a New Small-Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) in Preclinical Models of B-Cell Lymphoma and Acute Myeloid Leukemia by Perez-Salvia, Montserrat, Eneko, Aldaba, Yosu, Vara, Myriam, Fabre, Cristina, Ferrer, Carme, Masdeu, Aizpea, Zubia, Eider, San Sebastian, Dorleta, Otaegui, Pere, Llinàs-Arias, Margalida, Rosselló-Tortella, Maria, Berdasco, Fernando, Setien, Catia, Moutinho, Alberto, Villanueva, González-Barca, Eva, Muncunill, Josep, Navarro, Jose Tomas, Piris, Miguel Angel, Fernando, Cossio, Esteller, Manel

“…Histone deacetylase 6 (HDAC6) is a protein modifier that is an increasingly attractive pharmacological target. Interestingly, the observation that the HDAC6…”
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Resonance driven regioselective demethylation of berberine. Microwave assisted synthesis of berberrubine and its assessment as fluorescent chemosensor for alkanes by Delgado-Camón, Arantzazu, Jarne, Carmen, Cebolla, Vicente L., Larrañaga, Olatz, de Cózar, Abel, Cossío, Fernando P., Vara, Yosu, Domínguez, Andrés, Membrado, Luis, Galbán, Javier, Garriga, Rosa

“…Berberrubine has been synthesized by microwave assisted selective demethylation of berberine. The high selectivity observed in this reaction has been explained…”
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In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma by Pérez Salvia, Montserrat, Aldaba, Eneko, Vara, Yosu, Fabre, Myriam, Ferrer, Cristina, Masdeu, Carme, Zubia, Aizpea, San Sebastian, Eider, Otaegui, Dorleta, Llinàs-Arias, Pere, Rosselló-Tortella, Margalida, Berdasco, María, Moutinho, Cátia, Setién, Fernando, Villanueva Garatachea, Alberto, González Barca, Eva, Muncunill, Josep, Navarro, José-Tomás, Piris, Miguel A, Cossio, Fernando P, Esteller, Manel

“…Cancer origin and development is associated not only with genetic alterations, but also with the disturbance of epigenetic profiles.1 In this regard, the…”
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Design, Synthesis, and Functional Evaluation of Leukocyte Function Associated Antigen‑1 Antagonists in Early and Late Stages of Cancer Development by San Sebastián, Eider, Zimmerman, Tahl, Zubia, Aizpea, Vara, Yosu, Martin, Elyette, Sirockin, Finton, Dejaegere, Annick, Stote, Roland H, Lopez, Xabier, Pantoja-Uceda, David, Valcárcel, María, Mendoza, Lorea, Vidal-Vanaclocha, Fernando, Cossío, Fernando P, Blanco, Francisco J

“…The integrin leukocyte function associated antigen 1 (LFA-1) binds the intercellular adhesion molecule 1 (ICAM-1) by its αL-chain inserted domain (I-domain)…”
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Trans-Stereoselectivity in the Reaction between Homophthalic Anhydride and Imines by Vara, Yosu, Bello, Tamara, Aldaba, Eneko, Arrieta, Ana, Pizarro, José L, Arriortua, María I, Lopez, Xabier, Cossío, Fernando P

“…The reaction between homophthalic anhydride and imines in the presence of TiCl4 and diisopropyl ethyl amine is trans-selective. Under these conditions, the…”
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Tandem [8 + 2] Cycloaddition―[2 + 6 + 2] Dehydrogenation Reactions Involving Imidazo[1,2-a]pyridines and Imidazo[1,2-a]pyrimidines by AGINAGALDE, Maialen, VARA, Yosu, ARRIETA, Ana, ZANGI, Ronen, CEBOLLA, Vicente L, DELGADO-CAMON, Arantzazu, COSSIO, Fernando P

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Development and validation of a LC-MS assay for the quantification of ikh12 a novel anti-tumor candidate in rat plasma and tissues and its application in a pharmacokinetic study by Otaegui, Dorleta, Masdeu, Carme, Aldaba, Eneko, Vara, Yosu, Zubia, Aizpea, San Sebastian, Eider, Alcalá, Maria, Villafruela, Sergio, Cossío, Fernando P., Rodriguez-Gascón, Alicia

“…IKH12 is a novel histone deacetylase 6 selective inhibitor. A rapid and sensitive liquid chromatography tandem mass spectrometry method was developed and…”
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Synthesis of 11C-labeled Kendine 91, a histone deacetylase inhibitor by Aginagalde, Maialen, Gómez-Vallejo, Vanessa, Vara, Yosu, Cossío, Fernando P., Llop, Jordi

“…In the present paper, the synthesis of 11C-labeled Kendine 91 (a HDAC inhibitor which has shown in vitro and in vivo activity in HCT 116 and MOLT 4 human…”
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Abstract C46: Design, synthesis, and functional evaluation of leukocyte-function associated antigen-1 (LFA-1) antagonists in early and late stages of cancer development by Sebastin, Eider San, Zimmerman, Tahl, Zubia, Aizpea, Vara, Yosu, Martin, Elyette, Dejaegere, Annick, Stote, Roland H., Lopez, Xabier, Pantoja-Uceda, David, Valcarcel, Maria, Mendoza, Lorea, Vidal-Vanaclocha, Fernando, Cossio, Fernando P., Blanco, Francisco J.

“…The integrin Leukocyte Function-associated Antigen-1 (LFA-1) recognizes and binds the Intercellular Adhesion Molecule-1 (ICAM-1) by its L chain Inserted domain…”
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