Search Results - "Yoshiyuki Suzuki"

Chaperone therapy for lysosomal and non-lysosomal protein misfolding diseases by Suzuki, Yoshiyuki

“…Chaperone therapy was introduced first as a new molecular therapeutic approach to lysosomal diseases. In a recent article, I reviewed the development of…”
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Chaperone therapy for molecular pathology in lysosomal diseases by Suzuki, Yoshiyuki

“…In lysosomal diseases, enzyme deficiency is caused by misfolding of mutant enzyme protein with abnormal steric structure that is expressed by gene mutation…”
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Predicting Dominant Genotypes in Norovirus Seasons in Japan by Suzuki, Yoshiyuki

“…Human noroviruses are an etiological agent of acute gastroenteritis. Since multiple genotypes co-circulate every season changing their proportions, it may be…”
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Chaperone therapy update: Fabry disease, GM1 -gangliosidosis and Gaucher disease by Suzuki, Yoshiyuki

“…Abstract Chaperone therapy is a newly developed molecular therapeutic approach to lysosomal diseases, a group of human genetic diseases causing severe brain…”
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Natural selection on the influenza virus genome by Suzuki, Yoshiyuki

“…Influenza viruses are the etiological agents of influenza. Although vaccines and drugs are available for the prophylaxis and treatment of influenza virus…”
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Emerging novel concept of chaperone therapies for protein misfolding diseases by SUZUKI, Yoshiyuki

“…Chaperone therapy is a newly developed molecular therapeutic approach to protein misfolding diseases. Among them we found unstable mutant enzyme proteins in a…”
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DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells by Sato, Hiro, Niimi, Atsuko, Yasuhara, Takaaki, Permata, Tiara Bunga Mayang, Hagiwara, Yoshihiko, Isono, Mayu, Nuryadi, Endang, Sekine, Ryota, Oike, Takahiro, Kakoti, Sangeeta, Yoshimoto, Yuya, Held, Kathryn D., Suzuki, Yoshiyuki, Kono, Koji, Miyagawa, Kiyoshi, Nakano, Takashi, Shibata, Atsushi

“…Accumulating evidence suggests that exogenous cellular stress induces PD-L1 upregulation in cancer. A DNA double-strand break (DSB) is the most critical type…”
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Evidence for N-Glycan Shielding of Antigenic Sites during Evolution of Human Influenza A Virus Hemagglutinin by KOBAYASHI, Yuki, SUZUKI, Yoshiyuki

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Predicting receptor functionality of signaling lymphocyte activation molecule for measles virus hemagglutinin by docking simulation by Suzuki, Yoshiyuki

“…ABSTRACT Predicting susceptibility of various species to a virus assists assessment of risk of interspecies transmission. Evaluation of receptor functionality…”
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Prognostic Impact of Surgical Intervention After Lenvatinib Treatment for Advanced Hepatocellular Carcinoma by Shindoh, Junichi, Kawamura, Yusuke, Kobayashi, Yuta, Kobayashi, Masahiro, Akuta, Norio, Okubo, Satoshi, Suzuki, Yoshiyuki, Hashimoto, Masaji

“…Background With the introduction of new molecular-targeted agents, an increasing number of patients with advanced hepatocellular carcinoma (HCC) are benefiting…”
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A candidate packaging signal of human rotavirus differentiating Wa-like and DS-1-like genomic constellations by Suzuki, Yoshiyuki

“…ABSTRACT Rotavirus A (RVA) possesses a genome of 11 segmented RNAs. In human RVA, two major genomic constellations are represented by prototype strains Wa and…”
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PD‐L1 expression is mainly regulated by interferon gamma associated with JAK‐STAT pathway in gastric cancer by Mimura, Kousaku, Teh, Jun Liang, Okayama, Hirokazu, Shiraishi, Kensuke, Kua, Ley‐Fang, Koh, Vivien, Smoot, Duane T., Ashktorab, Hassan, Oike, Takahiro, Suzuki, Yoshiyuki, Fazreen, Zul, Asuncion, Bernadette R., Shabbir, Asim, Yong, Wei‐Peng, So, Jimmy, Soong, Richie, Kono, Koji

“…Despite multidisciplinary treatment for patients with advanced gastric cancer, their prognosis remains poor. Therefore, the development of novel therapeutic…”
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The neutral theory of molecular evolution in the genomic era by Nei, Masatoshi, Suzuki, Yoshiyuki, Nozawa, Masafumi

“…The neutral theory of molecular evolution has been widely accepted and is the guiding principle for studying evolutionary genomics and the molecular basis of…”
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Impact of sodium glucose cotransporter 2 inhibitor on histological features and glucose metabolism of non‐alcoholic fatty liver disease complicated by diabetes mellitus by Akuta, Norio, Kawamura, Yusuke, Watanabe, Chizuru, Nishimura, Akihiro, Okubo, Minoru, Mori, Yasumichi, Fujiyama, Shunichiro, Sezaki, Hitomi, Hosaka, Tetsuya, Kobayashi, Masahiro, Kobayashi, Mariko, Saitoh, Satoshi, Suzuki, Fumitaka, Suzuki, Yoshiyuki, Arase, Yasuji, Ikeda, Kenji, Kumada, Hiromitsu

“…Aim The aim of this study was to investigate the therapeutic potential of sodium glucose cotransporter 2 inhibitor (SGLT2I) as an effective therapeutic option…”
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Comprehensive analysis of endogenous bornavirus-like elements in eukaryote genomes by Horie, Masayuki, Kobayashi, Yuki, Suzuki, Yoshiyuki, Tomonaga, Keizo

“…Bornaviruses are the only animal RNA viruses that establish a persistent infection in their host cell nucleus. Studies of bornaviruses have provided unique…”
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Reliabilities of identifying positive selection by the branch-site and the site-prediction methods by Nozawa, Masafumi, Suzuki, Yoshiyuki, Nei, Masatoshi

“…Natural selection operating in protein-coding genes is often studied by examining the ratio (ω) of the rates of nonsynonymous to synonymous nucleotide…”
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Tofogliflozin Improves Insulin Resistance in Skeletal Muscle and Accelerates Lipolysis in Adipose Tissue in Male Mice by Obata, Atsushi, Kubota, Naoto, Kubota, Tetsuya, Iwamoto, Masahiko, Sato, Hiroyuki, Sakurai, Yoshitaka, Takamoto, Iseki, Katsuyama, Hisayuki, Suzuki, Yoshiyuki, Fukazawa, Masanori, Ikeda, Sachiya, Iwayama, Kaito, Tokuyama, Kumpei, Ueki, Kohjiro, Kadowaki, Takashi

“…Sodium glucose cotransporter 2 inhibitors have attracted attention as they exert antidiabetic and antiobesity effects. In this study, we investigated the…”
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Co-evolution in a putative bundling signal of bluetongue and epizootic hemorrhagic disease viruses by Suzuki, Yoshiyuki

“…Bluetongue virus (BTV) and epizootic hemorrhagic disease virus (EHDV) possess a genome of 10 segmented RNAs (S1–S10), one copy of each of which is considered…”
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Compensatory evolution of net-charge in influenza A virus hemagglutinin by Kobayashi, Yuki, Suzuki, Yoshiyuki

“…The propagation of influenza A virus depends on the balance between the activities of hemagglutinin (HA) for binding to host cells and neuraminidase (NA) for…”
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Detection of positive selection eliminating effects of structural constraints in hemagglutinin of H3N2 human influenza A virus by Suzuki, Yoshiyuki

“…► Positive selection can be detected eliminating effects of structural constraints. ► Positively selected sites were identified in hemagglutinin of influenza A…”
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