Search Results - "Yoshiyuki Kagawa"

Effect of Equipment Parameters on Amount and Dispersion of Wetting Liquid in Planetary Centrifugal Granulation by Miyazaki, Yasunori, Uchino, Tomonobu, Kagawa, Yoshiyuki

“…In planetary centrifugal wet granulation, the binder is often mixed into the formulation as a powder, followed by the addition of a wetting liquid, in a single…”
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Time–Course Changes in Lamotrigine Concentration after Addition of Valproate and the Safety and Long-Term Tolerability of Lamotrigine–Valproate Combination Therapy by Yamamoto, Yoshiaki, Usui, Naotaka, Kagawa, Yoshiyuki, Imai, Katsumi

“…The aim of this study was to evaluate the time–course changes in lamotrigine (LTG) concentration after addition of valproate (VPA) and the safety and…”
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Small-Scale Spherical Granulation Using a Planetary Centrifugal Mixer by Eda, Takashi, Miyazaki, Yasunori, Uchino, Tomonobu, Kagawa, Yoshiyuki

“…A concise spherical granulation method is required to prepare extemporaneously granules remanufactured from oral dosage forms for administration to individuals…”
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Evaluation of Dantrolene Granules Extemporaneously Reformulated from Capsules in a Pharmacy by Miyazaki, Yasunori, Tsuboi, Ayaka, Maruyama, Saori, Aoshima, Hiroaki, Uchino, Tomonobu, Kagawa, Yoshiyuki

“…Dantrolene capsule, an effective therapeutic agent for the treatment of spasticity, is administered to children who cannot swallow the capsule after…”
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Changes in Perampanel Pharmacokinetics and Cytochrome P450 3A4 Activity Before, During, and After Pregnancy by Yamamoto, Yoshiaki, Akita, Naoto, Nogimoto, Hiroki, Suzuki, Wakana, Imai, Katsumi, Takahashi, Yukitoshi, Kagawa, Yoshiyuki

“…This study evaluated perampanel pharmacokinetics and cytochrome P450 3A4 (CYP3A4) activity, assessed using the level of 4β-hydroxycholesterol (4β-OHC) as an…”
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Impact of CYP2D6, CYP3A5, and ABCB1 Polymorphisms on Plasma Concentrations of Donepezil and Its Metabolite in Patients With Alzheimer Disease by Kagawa, Yoshiyuki, Yamamoto, Yoshiaki, Ueno, Ayami, Maeda, Toshio, Obi, Tomokazu

“…Donepezil is one of the most commonly prescribed drugs for the treatment of Alzheimer disease. It is predominantly metabolized through CYP2D6 and to a lesser…”
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Clinical value of therapeutic drug monitoring for levetiracetam in pediatric patients with epilepsy by Yamamoto, Yoshiaki, Ohta, Akiko, Usui, Naotaka, Imai, Katsumi, Kagawa, Yoshiyuki, Takahashi, Yukitoshi

“…To identify pediatric patients who require therapeutic drug monitoring (TDM) of levetiracetam (LEV). We retrospectively investigated 2413 routine therapeutic…”
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Effects of low-dose titration on the tolerability and safety of perampanel by Yamamoto, Yoshiaki, Shiratani, Yuka, Nishida, Takuji, Usui, Naotaka, Imai, Katsumi, Kagawa, Yoshiyuki, Takahashi, Yukitoshi

“…•Relation between perampanel titration and safety and tolerability was investigated.•Early occurrence of adverse events led to increased risk of perampanel…”
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Impact of Cilostazol Pharmacokinetics on the Development of Cardiovascular Side Effects in Patients with Cerebral Infarction by Yokoyama, Tasuku, Yamauchi, Shigeru, Yamagata, Keishi, Kaneshiro, Yuta, Urano, Yumiko, Murata, Keiji, Maeda, Toshio, Asahara, Yoshinori, Kagawa, Yoshiyuki

“…This study investigated the impact of polymorphisms of metabolic enzymes on plasma concentrations of cilostazol and its metabolites, and the influence of the…”
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Therapeutic Drug Monitoring for Rufinamide in Japanese Patients With Epilepsy: Focus on Drug Interactions, Tolerability, and Clinical Effectiveness by Yamamoto, Yoshiaki, Inoue, Yushi, Usui, Naotaka, Imai, Katsumi, Kagawa, Yoshiyuki, Takahashi, Yukitoshi

“…The purposes of this study were to assess drug interactions between rufinamide and concomitant antiepileptic drugs (AEDs) and to identify the therapeutic…”
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Therapeutic Drug Monitoring for Perampanel in Japanese Epilepsy Patients: Influence of Concomitant Antiepileptic Drugs by Yamamoto, Yoshiaki, Usui, Naotaka, Nishida, Takuji, Takahashi, Yukitoshi, Imai, Katsumi, Kagawa, Yoshiyuki, Inoue, Yushi

“…Perampanel is a new antiepileptic drug (AED) that acts as a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor antagonist and…”
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Study on the drug permeation mechanism from flurbiprofen-loaded glyceryl monooleyl ether-based lyotropic liquid crystalline nanoparticles across the skin: Synchrotron X-ray diffraction and confocal laser scanning microscopy study by Uchino, Tomonobu, Kato, Sayaka, Hatta, Ichiro, Miyazaki, Yasunori, Suzuki, Tomonori, Sasaki, Kohta, Kagawa, Yoshiyuki

“…[Display omitted] The mechanism underlying the skin permeation of flurbiprofen (FLU)-loaded, glyceryl monooleyl ether-based liquid crystalline nanoparticles…”
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Small-Scale Spherical Granulation Using a Planetary Centrifugal Mixer by Takashi Eda, Yasunori Miyazaki, Tomonobu Uchino, Yoshiyuki Kagawa

“…A concise spherical granulation method is required to prepare extemporaneously granules remanufactured from oral dosage forms for administration to individuals…”
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Extemporaneous preparation of rifampicin granules from capsules to improve usability by Miyazaki, Yasunori, Uchino, Tomonobu, Kagawa, Yoshiyuki

“…ObjectivesManipulation of tablets or capsules is frequently carried out in pharmacies to regulate doses for personalised therapy. We proposed the use of…”
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Change in the pharmacokinetics of lacosamide before, during, and after pregnancy by Fukushima, Yutaro, Yamamoto, Yoshiaki, Yamazaki, Etsuko, Imai, Katsumi, Kagawa, Yoshiyuki, Takahashi, Yukitoshi

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Case of bullous pemphigoid refractory to corticosteroids by antiepileptic drug‐induced CYP3A4 by Asakawa, Riko, Ogawa, Youichi, Maejima, Eri, Honobe‐Tabuchi, Akiko, Okamoto, Takashi, Mitsui, Hiroshi, Kagawa, Yoshiyuki, Shimada, Shinji, Kawamura, Tatsuyoshi

“…The most common treatment option for patients with bullous pemphigoid is systemic corticosteroids. CYP3A4, a drug‐metabolizing enzyme in the liver, metabolizes…”
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Influence of antiepileptic drugs on serum lipid levels in adult epilepsy patients by Yamamoto, Yoshiaki, Terada, Kiyohito, Takahashi, Yukitoshi, Imai, Katsumi, Kagawa, Yoshiyuki, Inoue, Yushi

“…Highlights • Use of enzyme-inducing antiepileptic drug caused a marked increase of lipid levels. • Carbamazepine had a strong influence on lipid levels. •…”
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Influence of molecular weight and structure on diffusion rates and mechanisms of dextran polyelectrolyte complexes by Miyazaki, Yasunori, Mieno, Midori, Uchino, Tomonobu, Kagawa, Yoshiyuki

“…•Polyelectrolyte complex-forming tablets were prepared using dextran derivatives.•Swelling behaviors of the tablets were analyzed by front movement method in…”
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Development of a Novel Simple Gel Formulation Containing an Ion-Pair Complex of Diclofenac and Phenylephrine by Uchino, Tomonobu, Miyazaki, Yasunori, Ishikawa, Ayumi, Kagawa, Yoshiyuki

“…Since the pharmacological effects of diclofenac (DF) are short-lived because of its short half-life, prolongation of the pharmacological effect in a topical…”
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Compounding of low-dose pharmaceutical powders using a planetary centrifugal mixer by Miyazaki, Yasunori, Uchino, Tomonobu, Kagawa, Yoshiyuki

“…The low-dose mixing efficiency of planetary centrifugal mixer (PCM) was evaluated by measuring content uniformity of processed mixtures (coefficient of…”
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