Search Results - "Yoshino, Tetsuya"

Evaluation of the Aggregation States of Monoclonal Antibodies by Diverse and Complementary Methods by Yoshino, Tetsuya, Ishikawa, Tomoyoshi, Ishihara, Takashi, Takeuchi, Yoshimi, Yoshikawa, Hitomi, Yoshida, Hideaki, Yoshida, Hitoshi, Wakamatsu, Kaori

“…Therapeutic monoclonal antibodies (MAbs) with high specificity and fewer adverse effects are becoming widely used for the treatment of various diseases. MAbs…”
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Identification of Potent and Selective Inhibitors of PDGF Receptor Autophosphorylation by Furuta, Takayuki, Sakai, Teruyuki, Senga, Terufumi, Osawa, Tatsushi, Kubo, Kazuo, Shimizu, Toshiyuki, Suzuki, Rika, Yoshino, Tetsuya, Endo, Megumi, Miwa, Atsushi

“…We report the structure−activity relationship of quinoline and quinazoline derivatives, which include urea, thiourea, urethane, and acylthiourea groups, as…”
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Effects of the K+ Channel Opener KRN4884 on the Cardiovascular Metabolic Syndrome Model in Rats by Okada, Yuji, Yoshino, Tetsuya, Takeuchi, Akihiko, Endoh, Megumi, Ohta, Hideo, Jinno, Yasuhiro, Yokoyama, Takashi, Izawa, Toshio, Kobayashi, Eiichi

“…We examined the effects of the potassium channel opener KRN4884 (5-amino-N-[2-(2-chlorophenyl)ethyl]-N′-cyano-3-pyridinecarboxamidine) on cardiovascular…”
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Evi-1 Interacts with Histone Methyltransferases for Transcription Repression and Bone Marrow Transformation by Goyama, Susumu, Nitta, Eriko, Shimabe, Munetake, Yoshino, Tetsuya, Kako, Shinichi, Ichikawa, Motoshi, Imai, Yoichi, Takahashi, Tsuyoshi, Hangaishi, Akira, Kurokawa, Mineo

“…Evi-1 (ecotropic viral integration site-1) is a nuclear transcription factor containing multiple zinc finger motifs, and plays an essential role in the…”
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Orally active anti-proliferation agents : Novel diphenylamine derivatives as FGF-R2 autophosphorylation inhibitors by SHIMIZU, Toshiyuki, FUJIWARA, Yasunari, IWAI, Akemi, FUKUSHIMA, Kayoko, YOSHINO, Tetsuya, MIWA, Atsushi, OSAWA, Tatsushi, SAKAI, Teruyuki, KUBO, Kinya, KUBO, Kazuo, NISHITOBA, Tsuyoshi, KIMURA, Kaname, SENGA, Terufumi, MUROOKA, Hideko

“…(6,7-Disubstituted-quinolin-4-yloxy-phenyl)(4-substituted-phenyl)amine derivatives were synthesized and evaluated by a cellular autophosphorylation assay for…”
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Antineoplastic effect of a single oral dose of the novel Flt3 inhibitor KRN383 on xenografted human leukemic cells harboring Flt3-activating mutations by Nishiyama, Uichi, Yoshino, Tetsuya, Ozai, Masako, Yoshioka, Rieko, Fujisawa, Motoko, Ogasawara, Yuko, Kitahori, Miyuki, Yoshioka, Eiji, Kubo, Kazuo, Komeno, Yukiko, Kurokawa, Mineo, Ogawa, Seishi, Chiba, Shigeru, Osawa, Tatsushi, Kuwaki, Tomoaki, Hirai, Hisamaru, Miwa, Atsushi

“…Activating mutations of Fms-like tyrosine kinase 3 (Flt3) are the most common genetic abnormalities found in acute myeloid leukemia (AML) and represent…”
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Corrigendum to “Antineoplastic effect of a single oral dose of the novel Flt3 inhibitor KRN383 on xenografted human leukemic cells harboring Flt3-activating mutations” [Leuk. Res. 30 (2006) 1541–1546] by Nishiyama, Uichi, Yoshino, Tetsuya, Ozai, Masako, Yoshioka, Rieko, Fujisawa, Motoko, Ogasawara, Yuko, Kitahori, Miyuki, Yoshioka, Eiji, Kubo, Kazuo, Komeno, Yukiko, Kurokawa, Mineo, Ogawa, Seishi, Chiba, Shigeru, Osawa, Tatsushi, Kuwaki, Tomoaki, Hirai, Hisamaru, Miwa, Atsushi

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Preparation of a whole genome phage library using fragmented Escherichia coli genome and its characterization of protein binding properties by surface plasmon resonance by Yano, Kazuyoshi, Yoshino, Tetsuya, Shionoya, Makoto, Sawata, Shinya Y., Ikebukuro, Kazunori, Karube, Isao

“…A novel phage library has been prepared using the Escherichia coli genome digested with three restriction enzymes. The resulting DNA fragments were ligated to…”
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Ki23819 (KRN383•HCl) Inhibits Kinase Activity of Wild Type and Mutant FLT3 Receptor Tyrosine Kinase In Vitro by Komeno, Yukiko, Kurokawa, Mineo, Imai, Yoichi, Takeshita, Masataka, Matsumura, Tomoko, Kubo, Kazuo, Yoshino, Tetsuya, Nishiyama, Uichi, Kuwaki, Tomoaki, Kubo, Kinya, Osawa, Tatsushi, Ogawa, Seishi, Chiba, Shigeru, Miwa, Atsushi, Hirai, Hisamaru

“…[Background] FLT3 is a class III receptor tyrosine kinase which is widely expressed on hematopoietic stem/progenitor cells. Two types of constitutively active…”
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Single Oral Administration of KRN383, a Novel Flt3 Inhibitor, Induces Eradication of the Xenograft Tumor Harboring Flt3 Mutation in Mice by Nishiyama, Uichi, Ozai, Masako, Yoshioka, Rieko, Yoshino, Tetsuya, Ogasawara, Yuko, Kitahori, Miyuki, Yoshioka, Eiji, Kubo, Kazuo, Komeno, Yukiko, Kurokawa, Mineo, Ogawa, Seishi, Chiba, Shigeru, Osawa, Tatsushi, Kuwaki, Tomoaki, Hirai, Hisamaru, Miwa, Atsushi

“…Constitutively activating mutations of the Flt3 receptor tyrosine kinase including internal tandem duplication (ITD) mutations are the most common genetic…”
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Protective effect of the K+ channel opener KRN4884 on peripheral arterial occlusive disease in rats by Okada, Yuji, Ohshima, Ikuko, Ohta, Hideo, Jinno, Yasuhiro, Yoshino, Tetsuya, Torii, Yoshifumi, Ogawa, Nobuyuki, Izawa, Toshio

“…The effect of the potassium channel opener KRN4884 on the peripheral arterial occlusion model induced by laurate (1.0 mg/leg, i.a.) was examined and compared…”
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Effects of the K+ channel opener KRN4884 on multiple risk factor Tor cardiovascular disease in fructose-fed rats by Endoh, Megumi, Okada, Yuji, Yoshino, Tetsuya, Jinno, Yasuhiro, Ohta, Hideo, Nihei, Keiko, Ohshima, Ikuko, Izawa, Toshio

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Protective Effect of the K + Channel Opener KRN4884 on Peripheral Occlusive Arterial Disease in Rats by Yoshino, Tetsuya, Ohta, Hideo, Jinno, Yasuhiro, Torii, Yoshifumi, Ogawa, Nobuyuki, Izawa, Toshio, Okada, Yuji

“…1. The effect of the potassium channel opener KRN4884 on the peripheral arterial occlusion model induced by laurate was examined and compared with that of…”
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