Search Results - "Yoshinaga, Steven K"

An aberrant STAT pathway is central to COVID-19 by Matsuyama, Toshifumi, Kubli, Shawn P., Yoshinaga, Steven K., Pfeffer, Klaus, Mak, Tak W.

“…COVID-19 is caused by SARS-CoV-2 infection and characterized by diverse clinical symptoms. Type I interferon (IFN-I) production is impaired and severe cases…”
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Comorbidity-associated glutamine deficiency is a predisposition to severe COVID-19 by Matsuyama, Toshifumi, Yoshinaga, Steven K., Shibue, Kimitaka, Mak, Tak W.

“…SARS-CoV-2 vaccinations have greatly reduced COVID-19 cases, but we must continue to develop our understanding of the nature of the disease and its effects on…”
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Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element by Diamond, Marc I., Miner, Jeffrey N., Yoshinaga, Steven K., Yamamoto, Keith R.

“…The mechanism by which a single factor evokes opposite regulatory effects from a specific DNA sequence is not well understood. In this study, a 25-base pair…”
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Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS by Yoshinaga, Steven K., Zhang, Ming, Pistillo, Jeanne, Horan, Tom, Khare, Sanjay D., Miner, Kent, Sonnenberg, Michael, Boone, Tom, Brankow, David, Dai, Tianang, Delaney, John, Han, Hong, Hui, Ariela, Kohno, Tadahiko, Manoukian, Raffi, Whoriskey, John S., Coccia, Marco A.

“…Optimal T cell activation requires the interactions of co-stimulatory molecules, such as those in the CD28 and B7 protein families. Recently, we described the…”
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The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses by Suh, Woong-Kyung, Mak, Tak W, Gajewska, Beata U, Okada, Hitoshi, Gronski, Matthew A, Bertram, Edward M, Dawicki, Wojciech, Duncan, Gordon S, Bukczynski, Jacob, Plyte, Suzanne, Elia, Andrew, Wakeham, Andrew, Itie, Annick, Chung, Stephen, Da Costa, Joan, Arya, Sudha, Horan, Tom, Campbell, Pauline, Gaida, Kevin, Ohashi, Pamela S, Watts, Tania H, Yoshinaga, Steven K, Bray, Mark R, Jordana, Manel

“…We investigated the in vivo function of the B7 family member B7-H3 (also known as B7RP-2) by gene targeting. B7-H3 inhibited T cell proliferation mediated by…”
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T-cell co-stimulation through B7RP-1 and ICOS by Yoshinaga, Steven K, Whoriskey, John S, Khare, Sanjay D, Sarmiento, Ulla, Guo, Jane, Horan, Tom, Shih, Grace, Zhang, Ming, Coccia, Marco A, Kohno, Tadahiko, Tafuri-Bladt, Anna, Brankow, David, Campbell, Pauline, Chang, David, Chiu, Laura, Dai, Tianang, Duncan, Gordon, Elliott, Gary S, Hui, Ariela, McCabe, Susan M, Scully, Sheila, Shahinian, Arda, Shaklee, Christine L, Van, Gwyneth, Mak, Tak W, Senaldi, Giorgio

“…T-cell activation requires co-stimulation through receptors such as CD28 (refs 1,2,3) and antigen-specific signalling through the T-cell antigen receptor. Here…”
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Inducible costimulator costimulates cytotoxic activity and IFN-gamma production in activated murine NK cells by Ogasawara, Kouetsu, Yoshinaga, Steven K, Lanier, Lewis L

“…The functions of NK cells are regulated by the balance of activating and inhibitory signals. The inhibitory NK cell receptors are well understood; however,…”
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Essential role of NF-kappa B-inducing kinase in T cell activation through the TCR/CD3 pathway by Matsumoto, Mitsuru, Yamada, Takuji, Yoshinaga, Steven K, Boone, Tom, Horan, Tom, Fujita, Shigeru, Li, Yi, Mitani, Tasuku

“…NF-kappa B-inducing kinase (NIK) is involved in lymphoid organogenesis in mice through lymphotoxin-beta receptor signaling. To clarify the roles of NIK in T…”
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Renal tubular epithelial expression of the costimulatory molecule B7RP-1 (inducible costimulator ligand) by WAHL, Patricia, SCHOOP, Roland, BILIC, Grozdana, NEUWEILER, Jörg, LE HIR, Michel, YOSHINAGA, Steven K, WÜTHRICH, Rudolf P

“…MHC class II-expressing renal tubular epithelial cells (TEC) are able to present foreign peptide antigens to T cells. The costimulatory signals that are…”
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Roles of SWI1, SWI2, and SWI3 Proteins for Transcriptional Enhancement by Steroid Receptors by Yoshinaga, Steven K., Peterson, Craig L., Herskowitz, Ira, Yamamoto, Keith R.

“…The SWI1, SWI2, and SWI3 proteins, which are required for regulated transcription of numerous yeast genes, were found also to be essential for rat…”
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Transformation of NIH 3T3 Cells by HER3 or HER4 Receptors Requires the Presence of HER1 or HER2 (∗) by Zhang, Ke, Sun, Jilin, Liu, Naili, Wen, Duanzhi, Chang, David, Thomason, Arlen, Yoshinaga, Steven K.

“…Members of the epidermal growth factor receptor (EGFR) subfamily of receptor protein tyrosine kinases have been implicated in the pathogenesis of various…”
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In vitro Transcription Enhancement by Purified Derivatives of the Glucocorticoid Receptor by Freedman, Leonard P., Yoshinaga, Steven K., Vanderbilt, Jeff N., Yamamoto, Keith R.

“…Mammalian glucocorticoid receptors enhance transcription from linked promoters by binding to glucocorticoid response element (GRE) DNA sequences. Understanding…”
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Inducible Costimulator Protein Controls the Protective T Cell Response Against Listeria monocytogenes by Mittrucker, Hans-Willi, Kursar, Mischo, Kohler, Anne, Yanagihara, Donna, Yoshinaga, Steven K, Kaufmann, Stefan H. E

“…The inducible costimulator protein (ICOS) was recently identified as a costimulatory molecule for T cells. Here we analyze the role of ICOS for the acquired…”
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Stimulatory Effects of B7-Related Protein-1 on Cellular and Humoral Immune Responses in Mice by Guo, Jane, Stolina, Marina, Bready, James V, Yin, Songmei, Horan, Tom, Yoshinaga, Steven K, Senaldi, Giorgio

“…Inducible costimulator (ICOS) and B7-related protein-1 (B7RP-1) constitute a receptor-ligand pair involved in T cell costimulation. In this study, the…”
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Potent activity of soluble B7RP‐1‐Fc in therapy of murine tumors in syngeneic hosts by Ara, Gulshan, Baher, Angelo, Storm, Neal, Horan, Tom, Baikalov, Claudia, Brisan, Emil, Camacho, Reuben, Moore, Alison, Goldman, Hartt, Kohno, Tadahiko, Cattley, Russell C., Van, Gwyneth, Gaida, Kevin, Zhang, Ming, Whoriskey, John S., Fong, David, Yoshinaga, Steven K.

“…We have characterized a receptor:ligand pair, ICOS:B7RP‐1, that is structurally and functionally related to CD28:B7.1/2. We reported previously that B7RP‐1…”
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Interaction of B7RP-1 with ICOS negatively regulates antigen presentation by B cells by Wahl, Patricia, Schoop, Roland, Horan, Thomas P, Yoshinaga, Steven K, Wüthrich, Rudolf P

“…Stimulation of T cells through the T cell receptor is insufficient for optimal T cell activation. A second activation signal is necessary, being usually…”
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Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE) by Matsuyama, Toshifumi, Grossman, Alex, Mittrücker, Hans-Willi, Siderovski, David P., Kiefer, Friedemann, Kawakami, Takatoshi, Richardson, Christopher D., Taniguchi, Tadatsugu, Yoshinaga, Steven K., Mak, Tak W.

“…Interferon regulatory factor (IRF) genes encode a family of DNA-blndlng proteins that are involved in the transcriptional regulation of type-l Interferon…”
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Inducible Costimulator Costimulates Cytotoxic Activity and IFN-{gamma} Production in Activated Murine NK Cells by Ogasawara, Kouetsu, Yoshinaga, Steven K, Lanier, Lewis L

“…The functions of NK cells are regulated by the balance of activating and inhibitory signals. The inhibitory NK cell receptors are well understood; however,…”
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Signaling and regulation by a mammalian glucocorticoid receptor in Drosophila cells by Yoshinaga, S K, Yamamoto, K R

“…We demonstrate that the rat glucocorticoid receptor enhanced transcription in cultured Drosophila cells from Drosophila promoters linked to glucocorticoid…”
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Resolution of Human Transcription factor TFIIIC into Two Functional Components by YOSHINAGA, S. K, BOULANGER, P. A, BERK, A. J

“…tRNA genes and adenovirus viral-associated (VA) genes are transcribed by RNA polymerase III. Transcription of these genes in vitro requires two protein…”
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