Search Results - "Yoshimura, Shin"

LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis by Eguchi, Tomoya, Kuwahara, Tomoki, Sakurai, Maria, Komori, Tadayuki, Fujimoto, Tetta, Ito, Genta, Yoshimura, Shin-ichiro, Harada, Akihiro, Fukuda, Mitsunori, Koike, Masato, Iwatsubo, Takeshi

“…Leucine-rich repeat kinase 2 (LRRK2) has been associated with a variety of human diseases, including Parkinson’s disease and Crohn’s disease, whereas LRRK2…”
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The Evidence of Glioblastoma Heterogeneity by Soeda, Akio, Hara, Akira, Kunisada, Takahiro, Yoshimura, Shin-ichi, Iwama, Toru, Park, Deric M.

“…Cancers are composed of heterogeneous combinations of cells that exhibit distinct phenotypic characteristics and proliferative potentials. Because most cancers…”
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The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6 by Tsujimoto, Kohei, Jo, Tatsunori, Nagira, Daiki, Konaka, Hachiro, Park, Jeong Hoon, Yoshimura, Shin‐ichiro, Ninomiya, Akinori, Sugihara, Fuminori, Hirayama, Takehiro, Itotagawa, Eri, Matsuzaki, Yusei, Takaichi, Yuki, Aoki, Wataru, Saita, Shotaro, Nakamura, Shuhei, Ballabio, Andrea, Nada, Shigeyuki, Okada, Masato, Takamatsu, Hyota, Kumanogoh, Atsushi

“…The cellular activation of the NLRP3 inflammasome is spatiotemporally orchestrated by various organelles, but whether lysosomes contribute to this process…”
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TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes by Longatti, Andrea, Lamb, Christopher A, Razi, Minoo, Yoshimura, Shin-ichiro, Barr, Francis A, Tooze, Sharon A

“…Autophagy is a bulk degradation process characterized by the formation of double membrane vesicles called autophagosomes. The exact molecular mechanism of…”
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The Rab GTPase-binding protein EHBP1L1 and its interactors CD2AP/CIN85 negatively regulate the length of primary cilia via actin remodeling by Iwano, Tomohiko, Sobajima, Tomoaki, Takeda, Sén, Harada, Akihiro, Yoshimura, Shin-ichiro

“…Primary cilia are organelles consisting of axonemal microtubules and plasma membranes, and they protrude from the cell surface to the extracellular region and…”
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Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors by Yoshimura, Shin-ichiro, Gerondopoulos, Andreas, Linford, Andrea, Rigden, Daniel J, Barr, Francis A

“…A key requirement for Rab function in membrane trafficking is site-specific activation by GDP-GTP exchange factors (GEFs), but the majority of the 63 human…”
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Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C by Hsu, Chieh, Morohashi, Yuichi, Yoshimura, Shin-ichiro, Manrique-Hoyos, Natalia, Jung, SangYong, Lauterbach, Marcel A, Bakhti, Mostafa, Grønborg, Mads, Möbius, Wiebke, Rhee, JeongSeop, Barr, Francis A, Simons, Mikael

“…Oligodendrocytes secrete vesicles into the extracellular space, where they might play a role in neuron-glia communication. These exosomes are small vesicles…”
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The Rab11-binding protein RELCH/KIAA1468 controls intracellular cholesterol distribution by Sobajima, Tomoaki, Yoshimura, Shin-Ichiro, Maeda, Tomomi, Miyata, Haruhiko, Miyoshi, Eiji, Harada, Akihiro

“…Cholesterol, which is endocytosed to the late endosome (LE)/lysosome, is delivered to other organelles through vesicular and nonvesicular transport mechanisms…”
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Rab18 and a Rab18 GEF complex are required for normal ER structure by Gerondopoulos, Andreas, Bastos, Ricardo Nunes, Yoshimura, Shin-Ichiro, Anderson, Rachel, Carpanini, Sarah, Aligianis, Irene, Handley, Mark T, Barr, Francis A

“…The ancestral Rab GTPase Rab18 and both subunits of the Rab3GAP complex are mutated in the human neurological and developmental disorder Warburg Micro…”
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PACSIN1 is indispensable for amphisome-lysosome fusion during basal autophagy and subsets of selective autophagy by Oe, Yukako, Kakuda, Keita, Yoshimura, Shin-ichiro, Hara, Naohiro, Hasegawa, Junya, Terawaki, Seigo, Kimura, Yasuyoshi, Ikenaka, Kensuke, Suetsugu, Shiro, Mochizuki, Hideki, Yoshimori, Tamotsu, Nakamura, Shuhei

“…Autophagy is an indispensable process that degrades cytoplasmic materials to maintain cellular homeostasis. During autophagy, double-membrane autophagosomes…”
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Functional dissection of Rab GTPases involved in primary cilium formation by Yoshimura, Shin-ichiro, Egerer, Johannes, Fuchs, Evelyn, Haas, Alexander K, Barr, Francis A

“…Primary cilia are sensory structures involved in morphogen signalling during development, liquid flow in the kidney, mechanosensation, sight, and smell…”
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Loss of Rab6a in the small intestine causes lipid accumulation and epithelial cell death from lactation by Iwaki, Ayano, Moriwaki, Kenta, Sobajima, Tomoaki, Taniguchi, Manabu, Yoshimura, Shin‐ichiro, Kunii, Masataka, Kanda, Satoshi, Kamada, Yoshihiro, Miyoshi, Eiji, Harada, Akihiro

“…Intestinal epithelial cells (IECs) are not only responsible for the digestion and absorption of dietary substrates but also function as a first line of host…”
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Comparison of mesenchymal stem cells from adipose tissue and bone marrow for ischemic stroke therapy by Ikegame, Yuka, Yamashita, Kentaro, Hayashi, Shin-Ichiro, Mizuno, Hiroshi, Tawada, Masahiro, You, Fukka, Yamada, Kiyofumi, Tanaka, Yoshitaka, Egashira, Yusuke, Nakashima, Shigeru, Yoshimura, Shin-Ichi, Iwama, Toru

“…Abstract Background aims Transplantation of mesenchymal stromal cells (MSC) derived from bone marrow (BM) or adipose tissue is expected to become a cell…”
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Rab14 and Its Exchange Factor FAM116 Link Endocytic Recycling and Adherens Junction Stability in Migrating Cells by Linford, Andrea, Yoshimura, Shin-ichiro, Bastos, Ricardo Nunes, Langemeyer, Lars, Gerondopoulos, Andreas, Rigden, Daniel J., Barr, Francis A.

“…Rab GTPases define the vesicle trafficking pathways underpinning cell polarization and migration. Here, we find that Rab4, Rab11, and Rab14 and the candidate…”
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SNAP23 deficiency causes severe brain dysplasia through the loss of radial glial cell polarity by Kunii, Masataka, Noguchi, Yuria, Yoshimura, Shin-Ichiro, Kanda, Satoshi, Iwano, Tomohiko, Avriyanti, Erda, Atik, Nur, Sato, Takashi, Sato, Ken, Ogawa, Masaharu, Harada, Akihiro

“…In the developing brain, the polarity of neural progenitor cells, termed radial glial cells (RGCs), is important for neurogenesis. Intercellular adhesions,…”
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EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells by Nakajo, Atsuhiro, Yoshimura, Shin-ichiro, Togawa, Hiroko, Kunii, Masataka, Iwano, Tomohiko, Izumi, Ayaka, Noguchi, Yuria, Watanabe, Ayako, Goto, Ayako, Sato, Toshiro, Harada, Akihiro

“…The highly conserved Rab guanosine triphosphatase (GTPase) Rab8 plays a role in exocytosis toward the polarized plasma membrane in eukaryotic cells. In murine…”
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Epidermal Growth Factor Plays a Crucial Role in Mitogenic Regulation of Human Brain Tumor Stem Cells by Soeda, Akio, Inagaki, Akihito, Oka, Naoki, Ikegame, Yuka, Aoki, Hitomi, Yoshimura, Shin-ichi, Nakashima, Shigeru, Kunisada, Takahiro, Iwama, Toru

“…A cancer stem cell population in malignant brain tumors takes an essential part in brain tumor initiation, growth, and recurrence. Growth factors, such as…”
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Analysis of Rab GTPase-Activating Proteins Indicates that Rab1a/b and Rab43 Are Important for Herpes Simplex Virus 1 Secondary Envelopment by ZENNER, Helen L, YOSHIMURA, Shin-Ichiro, BARR, Francis A, CRUMP, Colin M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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ERK regulates Golgi and centrosome orientation towards the leading edge through GRASP65 by Bisel, Blaine, Wang, Yanzhuang, Wei, Jen-Hsuan, Xiang, Yi, Tang, Danming, Miron-Mendoza, Miguel, Yoshimura, Shin-ichiro, Nakamura, Nobuhiro, Seemann, Joachim

“…Directed cell migration requires the orientation of the Golgi and centrosome toward the leading edge. We show that stimulation of interphase cells with the…”
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Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells by Haas, Alexander K, Yoshimura, Shin-ichiro, Stephens, David J, Preisinger, Christian, Fuchs, Evelyn, Barr, Francis A

“…Rab GTPases control vesicle movement and tethering membrane events in membrane trafficking. We used the 38 human Rab GTPase activating proteins (GAPs) to…”
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