Search Results - "Yoshikawa, Yukitaka"

Mechanisms of the hepatoprotective effects of tamoxifen against drug-induced and chemical-induced acute liver injuries by Yoshikawa, Yukitaka, Miyashita, Taishi, Higuchi, Satonori, Tsuneyama, Koichi, Endo, Shinya, Tsukui, Tohru, Toyoda, Yasuyuki, Fukami, Tatsuki, Nakajima, Miki, Yokoi, Tsuyoshi

“…Although estrogen receptor (ER)α agonists, such as estradiol and ethinylestradiol (EE2), cause cholestasis in mice, they also reduce the degree of liver injury…”
Get full text

Establishment of knockdown of superoxide dismutase 2 and expression of CYP3A4 cell system to evaluate drug-induced cytotoxicity by Yoshikawa, Yukitaka, Hosomi, Hiroko, Fukami, Tatsuki, Nakajima, Miki, Yokoi, Tsuyoshi

“…Drug-induced hepatotoxicity is a major problem in drug development, and oxidative stress is known as one of the causes. Superoxide dismutases (SODs) are…”
Get full text

Knockdown of superoxide dismutase 2 enhances acetaminophen-induced hepatotoxicity in rat by Yoshikawa, Yukitaka, Morita, Mayu, Hosomi, Hiroko, Tsuneyama, Koichi, Fukami, Tatsuki, Nakajima, Miki, Yokoi, Tsuyoshi

“…Abstract Drug-induced hepatotoxicity is a major problem in drug development, and oxidative stress is known as one of the causes. Superoxide dismutases (SODs)…”
Get full text

Chimeric Mice With Humanized Livers Demonstrate Human-Specific Hepatotoxicity Caused by a Therapeutic Antibody Against TRAIL-Receptor 2/Death Receptor 5 by Nihira, Kaito, Nan-ya, Ken-ichiro, Kakuni, Masakazu, Ono, Yoko, Yoshikawa, Yukitaka, Ota, Toshio, Hiura, Masanori, Yoshinari, Kouichi

“…Abstract The activation of tumor necrosis factor (TNF)-related apoptosis-inducing ligand receptor 2 (TRAIL-R2)/death receptor 5 (DR5) induces apoptosis in…”
Get full text

Effect of antigen-dependent clearance on pharmacokinetics of anti-heparin-binding EGF-like growth factor (HB-EGF) monoclonal antibody by Kasai, Noriyuki, Yoshikawa, Yukitaka, Enokizono, Junichi

“…Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family and is an important therapeutic target in some types of human cancers. KM3566 is…”
Get full text

IL-4 mediates dicloxacillin-induced liver injury in mice by Higuchi, Satonori, Kobayashi, Masanori, Yoshikawa, Yukitaka, Tsuneyama, Koichi, Fukami, Tatsuki, Nakajima, Miki, Yokoi, Tsuyoshi

“…Drug-induced liver injury (DILI) is a major problem in drug development and clinical drug therapy. In most cases, the mechanisms are still unknown. It is…”
Get full text

An in vitro drug-induced hepatotoxicity screening system using CYP3A4-expressing and γ-glutamylcysteine synthetase knockdown cells by Hosomi, Hiroko, Akai, Sho, Minami, Keiichi, Yoshikawa, Yukitaka, Fukami, Tatsuki, Nakajima, Miki, Yokoi, Tsuyoshi

“…Drug-induced hepatotoxicity is often caused by CYP-dependent activation of the drugs into reactive metabolites. CYP3A4 is one of the main isoforms involved in…”
Get full text

Soluble heparin-binding EGF-like growth factor (HB-EGF) detected by newly developed immuno-PCR method is a clear-cut serological biomarker for ovarian cancer by Kasai, Noriyuki, Kobayashi, Kazuhiro, Shioya, Shinobu, Yoshikawa, Yukitaka, Yotsumoto, Fusanori, Miyamoto, Shingo, Mekada, Eisuke, Enokizono, Junichi

“…Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of growth factors that bind to and activate the EGF receptor. HB-EGF is…”
Get full text

An in vitro drug-induced hepatotoxicity screening system using CYP3A4-expressing and I[sup3-glutamylcysteine synthetase knockdown cells by Hosomi, Hiroko, Akai, Sho, Minami, Keiichi, Yoshikawa, Yukitaka, Fukami, Tatsuki, Nakajima, Miki, Yokoi, Tsuyoshi

“…Drug-induced hepatotoxicity is often caused by CYP-dependent activation of the drugs into reactive metabolites. CYP3A4 is one of the main isoforms involved in…”
Get full text

Effect of antigen-dependent clearance on pharmacokinetics of anti-heparin-binding EGF-like growth factor (HB-EGF) monoclonal antibody by Kasai, Noriyuki, Yoshikawa, Yukitaka, Enokizono, Junichi

“…Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family and is an important therapeutic target in some types of human cancers. KM3566 is…”
Get full text