Search Results - "Yoshikai, Y."

Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis by Yamada, H, Nakashima, Y, Okazaki, K, Mawatari, T, Fukushi, J-I, Kaibara, N, Hori, A, Iwamoto, Y, Yoshikai, Y

“…Recent animal studies have revealed critical roles of interleukin (IL)17, which is produced by a newly identified subset of helper T cells, Th17 cells, in the…”
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γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis by Monin, L., Ushakov, D. S., Arnesen, H., Bah, N., Jandke, A., Muñoz-Ruiz, M., Carvalho, J., Joseph, S., Almeida, B. C., Green, M. J., Nye, E., Hatano, S., Yoshikai, Y., Curtis, M., Carlsen, H., Steinhoff, U., Boysen, P., Hayday, A.

“…This most comprehensive analysis to date of γδ T cells in the murine uterus reveals them to compose a unique local T-cell compartment. Consistent with earlier…”
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Role of interleukin 15 in colitis induced by dextran sulphate sodium in mice by Yoshihara, K, Yajima, T, Kubo, C, Yoshikai, Y

“…Background and aims: Interleukin (IL)-15 is a member of the IL-2 family, stimulating dendritic cells, natural killer (NK) cells, NK T cells and memory CD8+ T…”
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Gene Expressions of Toll-Like Receptor 2, But Not Toll-Like Receptor 4, Is Induced by LPS and Inflammatory Cytokines in Mouse Macrophages by Matsuguchi, Tetsuya, Musikacharoen, Tipayaratn, Ogawa, Tomohiko, Yoshikai, Yasunobu

“…Toll-like receptors (TLRs) are a family of mammalian homologues of Drosophila Toll and play important roles in host defense. Two of the TLRs, TLR2 and TLR4,…”
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CD30L/CD30 is critical for maintenance of IL-17A-producing γδ T cells bearing Vγ6 in mucosa-associated tissues in mice by Sun, X, Shibata, K, Yamada, H, Guo, Y, Muta, H, Podack, E R, Yoshikai, Y

“…CD30 ligand (CD30L, CD153), a member of the tumor necrosis factor (TNF) superfamily, and its receptor CD30 are important for differentiation and activation of…”
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Lipopolysaccharide inhalation exacerbates allergic airway inflammation by activating mast cells and promoting Th2 responses by Murakami, D., Yamada, H., Yajima, T., Masuda, A., Komune, S., Yoshikai, Y.

“…Summary Background Bacterial infection occasionally exacerbates asthma, although the cellular and molecular mechanisms have not been well defined. An…”
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Levan (β-2, 6-fructan), a major fraction of fermented soybean mucilage, displays immunostimulating properties via Toll-like receptor 4 signalling: induction of interleukin-12 production and suppression of T-helper type 2 response and immunoglobulin E production by Xu, Q., Yajima, T., Li, W., Saito, K., Ohshima, Y., Yoshikai, Y.

“…Summary Background Products from the fermentation process of soybeans by Bacillus subtilis (natto) have been shown to possess anti‐tumour and immunomodulatory…”
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Cutting Edge: Naturally Occurring Soluble Form of Mouse Toll-Like Receptor 4 Inhibits Lipopolysaccharide Signaling by Iwami, Ken-ichiro, Matsuguchi, Tetsuya, Masuda, Akio, Kikuchi, Takeshi, Musikacharoen, Tipayaratn, Yoshikai, Yasunobu

“…Toll-like receptors (TLRs) are a family of proteins playing important roles in host defense. Mice defective of functional TLR4 are hyporesponsive to LPS,…”
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Gene Expression of Osteoclast Differentiation Factor Is Induced by Lipopolysaccharide in Mouse Osteoblasts Via Toll-Like Receptors by Kikuchi, Takeshi, Matsuguchi, Tetsuya, Tsuboi, Naotake, Mitani, Akio, Tanaka, Shigehisa, Matsuoka, Masanori, Yamamoto, Genta, Hishikawa, Toshimitsu, Noguchi, Toshihide, Yoshikai, Yasunobu

“…Osteoclast differentiation factor (ODF), a recently identified cytokine of the TNF family, is expressed as a membrane-associated protein in osteoblasts and…”
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NF-kappa B and STAT5 play important roles in the regulation of mouse Toll-like receptor 2 gene expression by Musikacharoen, T, Matsuguchi, T, Kikuchi, T, Yoshikai, Y

“…Toll-like receptor 2 (TLR2) is involved in the innate immunity by recognizing various bacterial components. We have previously reported that TLR2 gene…”
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Roles of prostaglandins and leukotrienes in acute inflammation caused by bacterial infection by Yoshikai, Yasunobu

“…Prostanoids, including prostaglandins and thromboxanes, are generated by the phospholipase A2/cyclooxygenase pathway, and leukotrienes are generated by the…”
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Serum levels of IL‐10, IL‐15 and soluble tumour necrosis factor‐alpha (TNF‐α) receptors in type C chronic liver disease by KAKUMU, S., OKUMURA, A., ISHIKAWA, T., YANO, M., ENOMOTO, A., NISHIMURA, H., YOSHIOKA, K., YOSHIKAI, Y.

“…We previously reported that the number of TNF‐α‐producing cells was increased in the liver of patients with type C chronic liver disease. To understand further…”
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Antibody‐Mediated T‐Cell Reduction or Increased Levels of Chimerism Overcome Resistance to Cyclophosphamide‐Induced Tolerance in NKT‐Deficient Mice by Onzuka, T., Tomita, Y., Okano, S., Shimizu, I., Yamada, H., Yoshikai, Y., Tominaga, R.

“…We reported that invariant NKT‐cell knockout (iNKT KO) mice are resistant to the induction of intrathymic chimerism and clonal deletion in the cyclophosphamide…”
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Overexpression of IL-15 In Vivo Enhances Protection Against Mycobacterium bovis Bacillus Calmette-Guerin Infection Via Augmentation of NK and T Cytotoxic 1 Responses by Umemura, Masayuki, Nishimura, Hitoshi, Hirose, Kenji, Matsuguchi, Tetsuya, Yoshikai, Yasunobu

“…To investigate the immunomodulating effects of IL-15 in vivo on mycobacterial infection, we used IL-15-transgenic (Tg) mice, which were recently constructed…”
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Effects of Lipopolysaccharide on the Induction of Mixed Chimerism in Cyclophosphamide‐Induced Tolerance by Onzuka, T., Tomita, Y., Shimizu, I., Okano, S., Yamada, H., Yoshikai, Y., Tominaga, R.

“…Cyclophosphamide (CP)‐induced tolerance is a mixed chimerism‐based tolerance and is one of the strategies used to induce transplant tolerance. Toll‐like…”
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Cot/Tpl2 is Essential for RANKL Induction by Lipid A in Osteoblasts by Kikuchi, T., Yoshikai, Y., Miyoshi, J., Katsuki, M., Musikacharoen, T., Mitani, A., Tanaka, S., Noguchi, T., Matsuguchi, T.

“…Lipopolysaccharide (LPS) is a pathogenic factor that increases bone resorption in periodontal diseases. LPS treatment of osteoblasts was shown to induce the…”
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Semi‐Allogeneic Dendritic Cells Injected via the Intratumoural Injection Route Show Efficient Antitumour Effects in Cooperation with Host‐Derived Professional Antigen‐Presenting Cells by Kondoh, H, Okano, S, Yoshida, K, Yonemitsu, Y, Tomita, Y, Yoshikai, Y, Wake, N, Sueishi, K

“…Dendritic cells (DC)‐based immunotherapy is a potent anticancer modality. In DC‐based immunotherapy, allogeneic DC may be an alternative source, but the…”
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A Novel Mitogen-Activated Protein Kinase Phosphatase Is an Important Negative Regulator of Lipopolysaccharide-Mediated c-Jun N-Terminal Kinase Activation in Mouse Macrophage Cell Lines by Matsuguchi, Tetsuya, Musikacharoen, Tipayaratn, Johnson, Thomas R., Kraft, Andrew S., Yoshikai, Yasunobu

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Novel roles of osteopontin and CXC chemokine ligand 7 in the defence against mycobacterial infection by Khajoee, V., Saito, M., Takada, H., Nomura, A., Kusuhara, K., Yoshida, S.‐I., Yoshikai, Y., Hara, T.

“…Summary Granulocyte‐macrophage colony‐stimulating factor (GM‐CSF)‐induced human monocyte‐derived macrophage (GM‐Mφ) or macrophage CSF (M‐CSF)‐induced human…”
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Overexpression of IL-15 In Vivo Enhances Tc1 Response, Which Inhibits Allergic Inflammation in a Murine Model of Asthma by Ishimitsu, Ryotaro, Nishimura, Hitoshi, Yajima, Toshiki, Watase, Taketo, Kawauchi, Hideyuki, Yoshikai, Yasunobu

“…IL-15, a pleiotropic cytokine, is involved in the inflammatory responses in various infectious and autoimmune diseases. We have recently constructed…”
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