Comparison of Cryopreserved Homografts and Decellularized Porcine Heterografts Implanted in Sheep

: This study evaluated cryopreserved homografts (Group 1) and porcine heterografts decellularized with deoxicholic acid (Group 2), implanted in the right ventricular outflow tract of juvenile sheep. Two groups with four animals in each were used and all animals survived with good outcome. Animals w...

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Bibliographic Details
Published in:	Artificial organs Vol. 28; no. 4; pp. 366 - 370
Main Authors:	Costa, Francisco Diniz Affonso da, Dohmen, Pascal Maria, Lopes, Sergio Veiga, Lacerda, Guilherme, Pohl, Felipe, Vilani, Ricardo, Brenner Affonso da Costa, Marise, Vieira, Eduardo Discher, Yoschi, S., Konertz, Wolfgang, Costa, Iseu Affonso da
Format:	Journal Article
Language:	English
Published:	Oxford, UK and Malden, USA Blackwell Science Inc 01-04-2004
Subjects:	Acellular Animals Aortic Bioprosthesis Calcification Calcinosis - diagnostic imaging Calcium - analysis Cryopreservation Extracellular Matrix - physiology Fibroblasts - metabolism Heart Valve Prosthesis Heart valves Pulmonary Pulmonary Valve - surgery Radiography Sheep Swine Tissue Engineering - methods
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Summary:	: This study evaluated cryopreserved homografts (Group 1) and porcine heterografts decellularized with deoxicholic acid (Group 2), implanted in the right ventricular outflow tract of juvenile sheep. Two groups with four animals in each were used and all animals survived with good outcome. Animals were sacrificed 90 or more days after surgery (90–150 days). On the third and fifth postoperative months they were submitted to echocardiographic examination with normal function and appearance observed for both groups. Explants were evaluated through histological analysis, atomic spectrophotometry and radiological examination. Calcium content was higher in the cusps of cryopreserved homografts, despite an otherwise similar macroscopic appearance between grafts of both groups. Decellularized heterografts were progressively repopulated by autologous cells suggesting some regenerative ability and longer durability than conventional homografts.
Bibliography:	ark:/67375/WNG-DH7ZTLMF-Z ArticleID:AOR47357 istex:EA8163CC6D9DFE6FC3EA88C92B212E58D0043197 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0160-564X 1525-1594
DOI:	10.1111/j.1525-1594.2004.47357.x