Search Results - "York, Autumn G"

Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity by Solis, Angel G., Bielecki, Piotr, Steach, Holly R., Sharma, Lokesh, Harman, Christian C. D., Yun, Sanguk, de Zoete, Marcel R., Warnock, James N., To, S. D. Filip, York, Autumn G., Mack, Matthias, Schwartz, Martin A., Dela Cruz, Charles. S., Palm, Noah W., Jackson, Ruaidhrí, Flavell, Richard A.

“…Direct recognition of invading pathogens by innate immune cells is a critical driver of the inflammatory response. However, cells of the innate immune system…”
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Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling by York, Autumn G., Williams, Kevin J., Argus, Joseph P., Zhou, Quan D., Brar, Gurpreet, Vergnes, Laurent, Gray, Elizabeth E., Zhen, Anjie, Wu, Nicholas C., Yamada, Douglas H., Cunningham, Cameron R., Tarling, Elizabeth J., Wilks, Moses Q., Casero, David, Gray, David H., Yu, Amy K., Wang, Eric S., Brooks, David G., Sun, Ren, Kitchen, Scott G., Wu, Ting-Ting, Reue, Karen, Stetson, Daniel B., Bensinger, Steven J.

“…Cellular lipid requirements are achieved through a combination of biosynthesis and import programs. Using isotope tracer analysis, we show that type I…”
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The translation of non-canonical open reading frames controls mucosal immunity by Jackson, Ruaidhrí, Kroehling, Lina, Khitun, Alexandra, Bailis, Will, Jarret, Abigail, York, Autumn G., Khan, Omair M., Brewer, J. Richard, Skadow, Mathias H., Duizer, Coco, Harman, Christian C. D., Chang, Lelina, Bielecki, Piotr, Solis, Angel G., Steach, Holly R., Slavoff, Sarah, Flavell, Richard A.

“…The annotation of the mammalian protein-coding genome is incomplete. Arbitrary size restriction of open reading frames (ORFs) and the absolute requirement for…”
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Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome by Hsieh, Wei-Yuan, Zhou, Quan D., York, Autumn G., Williams, Kevin J., Scumpia, Philip O., Kronenberger, Eliza B., Hoi, Xen Ping, Su, Baolong, Chi, Xun, Bui, Viet L., Khialeeva, Elvira, Kaplan, Amber, Son, Young Min, Divakaruni, Ajit S., Sun, Jie, Smale, Stephen T., Flavell, Richard A., Bensinger, Steven J.

“…Macrophages reprogram their lipid metabolism in response to activation signals. However, a systems-level understanding of how different pro-inflammatory…”
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Doxycycline alters metabolism and proliferation of human cell lines by Ahler, Ethan, Sullivan, William J, Cass, Ashley, Braas, Daniel, York, Autumn G, Bensinger, Steven J, Graeber, Thomas G, Christofk, Heather R

“…The tetracycline antibiotics are widely used in biomedical research as mediators of inducible gene expression systems. Despite many known effects of…”
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An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity by WILLIAMS, Kevin J, ARGUS, Joseph P, KOMISOPOULOU, Evangelia, HENKIN, Amy H, SOTO, Horacio, CHAMBERLAIN, Brian T, VERGNES, Laurent, JUNG, Michael E, TORRES, Jorge Z, LIAU, Linda M, CHRISTOFK, Heather R, PRINS, Robert M, YUE ZHU, MISCHEL, Paul S, REUE, Karen, GRAEBER, Thomas G, BENSINGER, Steven J, WILKS, Moses Q, MARBOIS, Beth N, YORK, Autumn G, KIDANI, Yoko, POURZIA, Alexandra L, AKHAVAN, David, LISIERO, Dominique N

“…The sterol regulatory element-binding proteins (SREBP) are key transcriptional regulators of lipid metabolism and cellular growth. It has been proposed that…”
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Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3 by Meyer, Krista D, Donner, Aaron J, Knuesel, Matthew T, York, Autumn G, Espinosa, Joaquín M, Taatjes, Dylan J

“…The human Mediator complex is generally required for expression of protein‐coding genes. Here, we show that the GCN5L acetyltransferase stably associates with…”
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Skin-resident innate lymphoid cells converge on a pathogenic effector state by Bielecki, Piotr, Riesenfeld, Samantha J., Hütter, Jan-Christian, Torlai Triglia, Elena, Kowalczyk, Monika S., Ricardo-Gonzalez, Roberto R., Lian, Mi, Amezcua Vesely, Maria C., Kroehling, Lina, Xu, Hao, Slyper, Michal, Muus, Christoph, Ludwig, Leif S., Christian, Elena, Tao, Liming, Kedaigle, Amanda J., Steach, Holly R., York, Autumn G., Skadow, Mathias H., Yaghoubi, Parastou, Dionne, Danielle, Jarret, Abigail, McGee, Heather M., Porter, Caroline B. M., Licona-Limón, Paula, Bailis, Will, Jackson, Ruaidhrí, Gagliani, Nicola, Gasteiger, Georg, Locksley, Richard M., Regev, Aviv, Flavell, Richard A.

“…Tissue-resident innate lymphoid cells (ILCs) help sustain barrier function and respond to local signals. ILCs are traditionally classified as ILC1, ILC2 or…”
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Cellular Stress-Induced Metabolites in Escherichia coli by Gatsios, Alexandra, Kim, Chung Sub, York, Autumn G., Flavell, Richard A., Crawford, Jason M.

“…Escherichia coli isolates commonly inhabit the human microbiota, yet the majority of E. coli’s small-molecule repertoire remains uncharacterized. We previously…”
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IL-10 constrains sphingolipid metabolism to limit inflammation by York, Autumn G., Skadow, Mathias H., Oh, Joonseok, Qu, Rihao, Zhou, Quan D., Hsieh, Wei-Yuan, Mowel, Walter K., Brewer, J. Richard, Kaffe, Eleanna, Williams, Kevin J., Kluger, Yuval, Smale, Stephen T., Crawford, Jason M., Bensinger, Steven J., Flavell, Richard A.

“…Interleukin-10 (IL-10) is a key anti-inflammatory cytokine that can limit immune cell activation and cytokine production in innate immune cell types 1 . Loss…”
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N‐Acyl Amides from Neisseria meningitidis and Their Role in Sphingosine Receptor Signaling by Cho, Wooyoung, York, Autumn G., Wang, Rurun, Wyche, Thomas P., Piizzi, Grazia, Flavell, Richard A., Crawford, Jason M.

“…Neisseria meningitidis is a Gram‐negative opportunistic pathogen that is responsible for causing human diseases with high mortality, such as septicemia and…”
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Subverting sterols: rerouting an oxysterol-signaling pathway to promote tumor growth by York, Autumn G, Bensinger, Steven J

“…Oxysterols are oxidized derivatives of cholesterol that are generated enzymatically or through autoxidation. Initially identified as important lipid signaling…”
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Skin-resident innate lymphoid cells converge on a pathogenic effector state by Bielecki, Piotr, Riesenfeld, Samantha J., Hütter, Jan-Christian, Torlai Triglia, Elena, Kowalczyk, Monika S., Ricardo-Gonzalez, Roberto R., Lian, Mi, Amezcua Vesely, Maria C., Kroehling, Lina, Xu, Hao, Slyper, Michal, Muus, Christoph, Ludwig, Leif S., Christian, Elena, Tao, Liming, Kedaigle, Amanda J., Steach, Holly R., York, Autumn G., Skadow, Mathias H., Yaghoubi, Parastou, Dionne, Danielle, Jarret, Abigail, McGee, Heather M., Porter, Caroline B. M., Licona-Limón, Paula, Bailis, Will, Jackson, Ruaidhrí, Gagliani, Nicola, Gasteiger, Georg, Locksley, Richard M., Regev, Aviv, Flavell, Richard A.

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Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins by Zhou, Quan D., Chi, Xun, Lee, Min Sub, Hsieh, Wei Yuan, Mkrtchyan, Jonathan J., Feng, An-Chieh, He, Cuiwen, York, Autumn G., Bui, Viet L., Kronenberger, Eliza B., Ferrari, Alessandra, Xiao, Xu, Daly, Allison E., Tarling, Elizabeth J., Damoiseaux, Robert, Scumpia, Philip O., Smale, Stephen T., Williams, Kevin J., Tontonoz, Peter, Bensinger, Steven J.

“…Plasma membranes of animal cells are enriched for cholesterol. Cholesterol-dependent cytolysins (CDCs) are pore-forming toxins secreted by bacteria that target…”
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Author Correction: Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity by Solis, Angel G., Bielecki, Piotr, Steach, Holly R., Sharma, Lokesh, Harman, Christian C. D., Yun, Sanguk, de Zoete, Marcel R., Warnock, James N., To, S. D. Filip, York, Autumn G., Mack, Matthias, Schwartz, Martin A., Cruz, Charles. S. Dela, Palm, Noah W., Jackson, Ruaidhrí, Flavell, Richard A.

“…An Amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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YYSkin-resident innate lymphoid cells converge on a pathogenic effector state by Bielecki, P, Riesenfeld, SJ, Hutter, JC, Triglia, ET, Kowalczyk, MS, Ricardo-Gonzalez, RR, Lian, M, Vesely, MCA, Kroehling, L, Xu, H, Slyper, M, Muus, C, Ludwig, LS, Christian, E, Tao, LM, Kedaigle, AJ, Steach, HR, York, AG, Skadow, MH, Yaghoubi, P, Dionne, D, Jarret, A, McGee, HM, Porter, CBM, Licona-Limon, P, Bailis, W, Jackson, R, Gagliani, N, Gasteiger, G, Locksley, RM, Regev, A, Flavell, RA

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