Search Results - "Yoon, Oh Kyu"

Systematic comparison of high-throughput single-cell RNA-seq methods for immune cell profiling by Yamawaki, Tracy M, Lu, Daniel R, Ellwanger, Daniel C, Bhatt, Dev, Manzanillo, Paolo, Arias, Vanessa, Zhou, Hong, Yoon, Oh Kyu, Homann, Oliver, Wang, Songli, Li, Chi-Ming

“…Elucidation of immune populations with single-cell RNA-seq has greatly benefited the field of immunology by deepening the characterization of immune…”
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RNA-seq RNAaccess identified as the preferred method for gene expression analysis of low quality FFPE samples by Song, Kai, Elboudwarej, Emon, Zhao, Xi, Zhuo, Luting, Pan, David, Liu, Jinfeng, Brachmann, Carrie, Patterson, Scott D, Yoon, Oh Kyu, Zavodovskaya, Marianna

“…Clinical tumor tissues that are preserved as formalin-fixed paraffin-embedded (FFPE) samples result in extensive cross-linking, fragmentation, and chemical…”
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Oral PD-L1 inhibitor GS-4224 selectively engages PD-L1 high cells and elicits pharmacodynamic responses in patients with advanced solid tumors by Odegard, Jared M, Othman, Ahmed A, Lin, Kai-Wen, Wang, Adele Y, Nazareno, Jonathan, Yoon, Oh Kyu, Ling, John, Lad, Latesh, Dunbar, P Rod, Thai, Dung, Ang, Edmond, Waldron, Nicholas, Deva, Sanjeev

“…BackgroundCheckpoint inhibitors targeting the programmed cell death 1 (PD-1)/programmed cell death 1 ligand 1 (PD-L1) pathway are effective therapies in a…”
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Genetics and regulatory impact of alternative polyadenylation in human B-lymphoblastoid cells by Yoon, Oh Kyu, Hsu, Tiffany Y, Im, Joo Hyun, Brem, Rachel B

“…Gene expression varies widely between individuals of a population, and regulatory change can underlie phenotypes of evolutionary and biomedical relevance. A…”
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Pharmacodynamic effects of filgotinib treatment driving clinical improvement in patients with active psoriatic arthritis enrolled in the EQUATOR trial by Chandran, Vinod, Malkov, Vladislav A, Ito, Kaori L, Liu, Yihua, Vestergaard, Lene, Yoon, Oh Kyu, Liu, Jinfeng, Trivedi, Mona, Hertz, Angie, Gladman, Dafna

“…ObjectivesThe goal of this study was to identify protein and transcriptional biomarkers and pathways associated with baseline disease state, the effect of…”
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Association of ambulatory blood pressure monitoring with renal outcome in patients with chronic kidney disease by Son, Hyung Eun, Ryu, Ji Young, Go, Suryeong, Yi, Youngjin, Kim, Kipyo, Oh, Yoon Kyu, Oh, Kook-Hwan, Chin, Ho Jun

“…The significance of ambulatory blood pressure (ABP) in Korean patients with chronic kidney disease (CKD) in relation to renal outcome or death remains unclear…”
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Upregulation of Na+ transporter abundances in response to chronic thiazide or loop diuretic treatment in rats by Na, Ki Young, Oh, Yoon Kyu, Han, Jin Suk, Joo, Kwon Wook, Lee, Jung Sang, Earm, Jae-Ho, Knepper, Mark A, Kim, Gheun-Ho

“…Furosemide and hydrochlorothiazide (HCTZ) exert their diuretic actions by binding to apical Na(+) transporters, viz., the Na(+)-K(+)-2Cl(-) cotransporter in…”
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Continuous Two-Channel Time-of-Flight Mass Spectrometric Detection of Electrosprayed Ions by Trapp, Oliver, Kimmel, Joel R., Yoon, Oh Kyu, Zuleta, Ignacio A., Fernandez, Facundo M., Zare, Richard N.

“…Flying to new destinations: Instrument modifications, which give three detection areas (see scheme) in a two‐channel detection scheme, extend the achievable…”
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Stopped-Flow Kinetic Analysis Using Hadamard Transform Time-of-Flight Mass Spectrometry by Robbins, Matthew D, Yoon, Oh Kyu, Barbula, Griffin K, Zare, Richard N

“…A home-built stopped-flow apparatus is interfaced to a Hadamard transform time-of-flight mass spectrometer, which permits study of reaction kinetics with a…”
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Overall survival with sacituzumab govitecan in hormone receptor-positive and human epidermal growth factor receptor 2-negative metastatic breast cancer (TROPiCS-02): a randomised, open-label, multicentre, phase 3 trial by Rugo, Hope S, Bardia, Aditya, Marmé, Frederik, Cortés, Javier, Schmid, Peter, Loirat, Delphine, Trédan, Olivier, Ciruelos, Eva, Dalenc, Florence, Gómez Pardo, Patricia, Jhaveri, Komal L, Delaney, Rosemary, Valdez, Theresa, Wang, Hao, Motwani, Monica, Yoon, Oh Kyu, Verret, Wendy, Tolaney, Sara M

“…Summary Background Sacituzumab govitecan demonstrated significant progression-free survival benefit over chemotherapy in the phase 3 TROPiCS-02 trial in…”
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Simple Template-Based Method to Produce Bradbury-Nielsen Gates by Yoon, Oh Kyu, Zuleta, Ignacio A., Robbins, Matthew D., Barbula, Griffin K., Zare, Richard N.

“…A Bradbury-Nielsen gate (BNG) consists of two interleaved and electrically isolated sets of wires and can transmit or deflect charged particles by applying a…”
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Antidiuretic action of oxytocin is associated with increased urinary excretion of aquaporin-2 by Joo, Kwon Wook, Jeon, Un Sil, Kim, Gheun-Ho, Park, Jungwhan, Oh, Yoon Kyu, Kim, Yon Su, Ahn, Curie, Kim, Suhnggwon, Kim, Seong Yeon, Lee, Jung Sang, Han, Jin Suk

“…Background. The antidiuretic effect of oxytocin in humans is controversial. Urinary excretion of aquaporin-2 (AQP2) can be used as an index of the action of…”
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Micromachined Bradbury−Nielsen Gates by Zuleta, Ignacio A, Barbula, Griffin K, Robbins, Matthew D, Yoon, Oh Kyu, Zare, Richard N

“…Bradbury−Nielsen gates (BNGs) are a standard way for gating or steering beams of charged particles in ion mobility spectrometry and time-of-flight mass…”
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Impact of delayed PBMC processing on functional and genomic assays by Yi, Ping-Cheng, Zhuo, Luting, Lin, Julie, Chang, Calvin, Goddard, Audrey, Yoon, Oh Kyu

“…Peripheral blood mononuclear cells (PBMCs) are commonly isolated from whole blood samples in clinical trials. Isolated PBMCs can be cryopreserved for use in…”
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Up-regulation of organic anion transporter 1 protein is induced by chronic furosemide or hydrochlorothiazide infusion in rat kidney by Kim, Gheun-Ho, Na, Ki Young, Kim, So-Young, Joo, Kwon Wook, Oh, Yoon Kyu, Chae, Seoung-Wan, Endou, Hitoshi, Han, Jin Suk

“…Background. Thiazide and loop diuretics are secreted from the proximal tubule via the organic anion transport system to reach their principal sites of action…”
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Continuous Time-of-Flight Ion Imaging: Application to Fragmentation by Yoon, Oh Kyu, Robbins, Matthew D, Zuleta, Ignacio A, Barbula, Griffin K, Zare, Richard N

“…We have designed and constructed a continuous imaging reflectron time-of-flight mass spectrometer (TOFMS) that provides a mass spectrum at every pixel of a…”
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Final Results From the Randomized Phase III ASCENT Clinical Trial in Metastatic Triple-Negative Breast Cancer and Association of Outcomes by Human Epidermal Growth Factor Receptor 2 and Trophoblast Cell Surface Antigen 2 Expression by Bardia, Aditya, Rugo, Hope S, Tolaney, Sara M, Loirat, Delphine, Punie, Kevin, Oliveira, Mafalda, Brufsky, Adam, Kalinsky, Kevin, Cortés, Javier, Shaughnessy, Joyce O', Diéras, Véronique, Carey, Lisa A, Gianni, Luca, Piccart-Gebhart, Martine, Loibl, Sibylle, Yoon, Oh Kyu, Pan, Yang, Hofsess, Scott, Phan, See-Chun, Hurvitz, Sara A

“…JCO Sacituzumab govitecan (SG), a first-in-class anti-trophoblast cell surface antigen 2 (Trop-2) antibody-drug conjugate, demonstrated superior efficacy over…”
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Trop-2 mRNA expression and association with clinical outcomes with sacituzumab govitecan (SG) in patients with HR+/HER2– metastatic breast cancer (mBC): Biomarker results from the phase 3 TROPiCS-02 study by Bardia, Aditya, Rugo, Hope S., Cortés, Javier, Tolaney, Sara M., Schmid, Peter, Motwani, Monica, Yoon, Oh Kyu, Boice, Jillian, Zhuo, Luting, Marmé, Frederik

“…1082 Background: SG is a Trop-2–directed antibody-drug conjugate approved in multiple countries for patients with metastatic triple-negative breast cancer who…”
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Effects of JAK1-Preferential Inhibitor Filgotinib on Circulating Biomarkers and Whole Blood Genes/Pathways of Patients With Moderately to Severely Active Crohn’s Disease by Roblin, Xavier, Serone, Adrian, Yoon, Oh Kyu, Zhuo, Luting, Grant, Ethan, Woo, Jacky, Liu, Jinfeng, Galien, René, D’Haens, Geert

“…Abstract Background Pro-inflammatory cytokines are dysregulated in Crohn’s disease (CD) and could serve as surrogate markers to improve diagnostic and…”
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Noncanonical transcript forms in yeast and their regulation during environmental stress by Yoon, Oh Kyu, Brem, Rachel B

“…Surveys of transcription in many organisms have observed widespread expression of RNAs with no known function, encoded within and between canonical coding…”
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