The Genome of the Natural Genetic Engineer Agrobacterium tumefaciens C58

The 5.67-megabase genome of the plant pathogen Agrobacterium tumefaciens C58 consists of a circular chromosome, a linear chromosome, and two plasmids. Extensive orthology and nucleotide colinearity between the genomes of A. tumefaciens and the plant symbiont Sinorhizobium meliloti suggest a recent e...

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Published in:	Science (American Association for the Advancement of Science) Vol. 294; no. 5550; pp. 2317 - 2323
Main Authors:	Wood, Derek W., Setubal, Joao C., Kaul, Rajinder, Monks, Dave E., Kitajima, Joao P., Okura, Vagner K., Zhou, Yang, Chen, Lishan, Wood, Gwendolyn E., Almeida, Nalvo F., Woo, Lisa, Chen, Yuching, Paulsen, Ian T., Eisen, Jonathan A., Karp, Peter D., Bovee, Donald, Chapman, Peter, Clendenning, James, Deatherage, Glenda, Gillet, Will, Grant, Charles, Kutyavin, Tatyana, Levy, Ruth, Li, Meng-Jin, McClelland, Erin, Palmieri, Anthony, Raymond, Christopher, Rouse, Gregory, Saenphimmachak, Channakhone, Wu, Zaining, Romero, Pedro, Gordon, David, Zhang, Shiping, Yoo, Heayun, Tao, Yumin, Biddle, Phyllis, Jung, Mark, Krespan, William, Perry, Michael, Gordon-Kamm, Bill, Liao, Li, Kim, Sun, Hendrick, Carol, Zhao, Zuo-Yu, Dolan, Maureen, Chumley, Forrest, Tingey, Scott V., Tomb, Jean-Francois, Gordon, Milton P., Olson, Maynard V., Nester, Eugene W.
Format:	Journal Article
Language:	English
Published:	Washington, DC American Society for the Advancement of Science 14-12-2001 American Association for the Advancement of Science The American Association for the Advancement of Science
Subjects:	Agricultural Production Agrobacterium tumefaciens Agrobacterium tumefaciens - classification Agrobacterium tumefaciens - genetics Agrobacterium tumefaciens - pathogenicity Agrobacterium tumefaciens - physiology ATP binding cassette transporters Bacteria Bacterial Adhesion - genetics Bacterial plant pathogens Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Biological and medical sciences Carrier Proteins - genetics Carrier Proteins - metabolism Chromosomes Chromosomes, Bacterial - genetics Coding Conjugation, Genetic Conservation (Concept) DNA Replication Evolution Evolution (Biology) Fundamental and applied biological sciences. Psychology Genes Genes, Bacterial Genes, Regulator Genetic aspects Genetic engineering Genetics Genome, Bacterial Genomes Genomics Membrane Proteins - genetics Membrane Proteins - metabolism Microbiology Molecular Sequence Data Phylogeny Phytopathology. Animal pests. Plant and forest protection Plants - microbiology Plasmids Replicon Rhizobiaceae Rhizobiaceae - genetics Rhizobiaceae - physiology Sequence Analysis, DNA Sinorhizobium meliloti Sinorhizobium meliloti - genetics Sinorhizobium meliloti - physiology Symbiosis Systematics. Structure, properties and multiplication. Genetics Virulence Virulence - genetics United States Plant pathogen Biological evolution Virulence Agrobacterium tumefaciens Chromosome Phylogeny Metabolism Genetic transfer Plasmid Regulation(control) Gene Bacteria Replication Rhizobiaceae Genome
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Summary:	The 5.67-megabase genome of the plant pathogen Agrobacterium tumefaciens C58 consists of a circular chromosome, a linear chromosome, and two plasmids. Extensive orthology and nucleotide colinearity between the genomes of A. tumefaciens and the plant symbiont Sinorhizobium meliloti suggest a recent evolutionary divergence. Their similarities include metabolic, transport, and regulatory systems that promote survival in the highly competitive rhizosphere; differences are apparent in their genome structure and virulence gene complement. Availability of the A. tumefaciens sequence will facilitate investigations into the molecular basis of pathogenesis and the evolutionary divergence of pathogenic and symbiotic lifestyles.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.1066804