An anti-estrogenic lignan glycoside, tracheloside, from seeds of Carthamus tinctorius

The lignan glycoside, tracheloside, was isolated from seeds of Carthamus tinctorius (Compositae) as an anti-estrogenic principle against cultured Ishikawa cells by employing a bioassay-linked HPLC-ELSD method. Tracheloside significantly decreased the activity of alkaline phosphatase (AP), an estroge...

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Bibliographic Details
Published in:	Bioscience, biotechnology, and biochemistry Vol. 70; no. 11; pp. 2783 - 2785
Main Authors:	Yoo, H.H.(Seoul National Univ. (Korea R.)), Park, J.H, Kwon, S.W
Format:	Journal Article
Language:	English
Published:	Tokyo Japan Society for Bioscience, Biotechnology, and Agrochemistry 01-11-2006 Japan Society for Bioscience Biotechnology and Agrochemistry Oxford University Press
Subjects:	4-Butyrolactone - analogs & derivatives 4-Butyrolactone - chemistry 4-Butyrolactone - pharmacology AISLAMIENTO ANTAGONISTAS DE LAS HORMONAS ANTAGONISTE D'HORMONE anti-estrogenic activity bioassay-linked HPLC-ELSD BIOASSAYS Biological and medical sciences CARTHAMUS TINCTORIUS Carthamus tinctorius - chemistry Cell Line CELLS CELLULE CELULAS ENSAYO ENSAYO BIOLOGICO Enzyme Activation - drug effects ESTROGENOS Estrogens - metabolism Fundamental and applied biological sciences. Psychology GLICOSIDOS Glucosides - chemistry Glucosides - pharmacology GLYCOSIDE GLYCOSIDES Glycosides - chemistry Glycosides - metabolism Glycosides - pharmacology GRAINE HORMONE ANTAGONISTS Ishikawa cell ISOLATION ISOLEMENT LIGNANAS LIGNANE LIGNANS Lignans - chemistry Lignans - metabolism Molecular Structure OESTROGENE OESTROGENS Plant Extracts - chemistry SEEDS Seeds - chemistry SEMILLA Solubility TEST BIOLOGIQUE TESTAGE TESTING tracheloside Bioassay HPLC chromatography Compositae Ishikawa cell anti-estrogenic activity Carthamus tinctorius bioassay- linked HPLC-ELSD Dicotyledones Angiospermae Lignan tracheloside Spermatophyta Glycoside
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Summary:	The lignan glycoside, tracheloside, was isolated from seeds of Carthamus tinctorius (Compositae) as an anti-estrogenic principle against cultured Ishikawa cells by employing a bioassay-linked HPLC-ELSD method. Tracheloside significantly decreased the activity of alkaline phosphatase (AP), an estrogen-inducible marker enzyme, with an ICsub(50) value of 0.31 micro g/ml, a level of inhibition comparable to that of tamoxifen (ICsub(50) = 0.43 micro g/ml).
Bibliography:	U40 2007006089 U30 Q04 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.60290