Gender-specific association between blood cell parameters and hyperuricemia in high-altitude areas

Hyperuricemia is a common metabolic disorder linked to various health conditions. Its prevalence varies among populations and genders, and high-altitude environments may contribute to its development. Understanding the connection between blood cell parameters and hyperuricemia in high-altitude areas...

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Bibliographic Details
Published in:	Frontiers in public health Vol. 12; p. 1336674
Main Authors:	Cui, Danli, Huang, Ruoying, Yongzong, Dexi, Lin, Bo, Huang, Xia, Ciren, Qimei, Zhou, Xuelian
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 25-03-2024
Subjects:	Altitude blood cell parameters Blood Cells Female gender differences high-altitude areas Humans hyperuricemia Hyperuricemia - epidemiology Male metabolic dynamics Public Health Urea Uric Acid hyperuricemia high-altitude areas gender differences blood cell parameters metabolic dynamics
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Summary:	Hyperuricemia is a common metabolic disorder linked to various health conditions. Its prevalence varies among populations and genders, and high-altitude environments may contribute to its development. Understanding the connection between blood cell parameters and hyperuricemia in high-altitude areas can shed light on the underlying mechanisms. This study aimed to investigate the relationship between blood cell parameters and hyperuricemia in high-altitude areas, with a particular focus on gender differences. We consecutively enrolled all eligible Tibetan participants aged 18-60 who were undergoing routine medical examinations at the People's Hospital of Chaya County between January and December 2022. During this period, demographic and laboratory data were collected to investigate the risk factors associated with hyperuricemia. Among the participants, 46.09% were diagnosed with hyperuricemia. In the male cohort, significant correlations were found between serum uric acid (SUA) levels and red blood cell (RBC) count, creatinine (Cr). Urea, alanine transaminase (ALT), and albumin (ALB). Notably, RBC exhibited the strongest association. Conversely, in the female cohort, elevated SUA levels were associated with factors such as white blood cell (WBC) count. Urea, ALT, and ALB, with WBC demonstrating the most significant association. Further analysis within the female group revealed a compelling relationship between SUA levels and specific white blood cell subtypes, particularly neutrophils (Neu). This study revealed gender-specific associations between SUA levels and blood cell parameters in high-altitude areas. In males, RBC count may play a role in hyperuricemia, while in females, WBC count appears to be a significant factor. These findings contribute to our understanding of metabolic dynamics in high-altitude regions but require further research for comprehensive mechanistic insights.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Bhuvnesh Kumar, Sharda University, India These authors have contributed equally to this work Reviewed by: Eduardo Gutiérrez-Abejón, Universidad de Valladolid, Spain Edited by: Weihong Chen, Huazhong University of Science and Technology, China
ISSN:	2296-2565 2296-2565
DOI:	10.3389/fpubh.2024.1336674