Search Results - "Yongchang Chang"

FastCloning: a highly simplified, purification-free, sequence- and ligation-independent PCR cloning method by Li, Chaokun, Wen, Aiyun, Shen, Benchang, Lu, Jia, Huang, Yao, Chang, Yongchang

“…Although a variety of methods and expensive kits are available, molecular cloning can be a time-consuming and frustrating process. Here we report a highly…”
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Exosomal DNA Aptamer Targeting α-Synuclein Aggregates Reduced Neuropathological Deficits in a Mouse Parkinson’s Disease Model by Ren, Xiaoxi, Zhao, Yun, Xue, Fenqin, Zheng, Yan, Huang, Haixia, Wang, Wei, Chang, Yongchang, Yang, Hui, Zhang, Jianliang

“…The α-synuclein aggregates are the main component of Lewy bodies in Parkinson’s disease (PD) brain, and they showed immunotherapy could be employed to…”
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Structural basis for hyperpolarization-dependent opening of human HCN1 channel by Burtscher, Verena, Mount, Jonathan, Huang, Jian, Cowgill, John, Chang, Yongchang, Bickel, Kathleen, Chen, Jianhan, Yuan, Peng, Chanda, Baron

“…Hyperpolarization and cyclic nucleotide (HCN) activated ion channels are critical for the automaticity of action potentials in pacemaking and rhythmic…”
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Novel DNA Aptamers for Parkinson’s Disease Treatment Inhibit α-Synuclein Aggregation and Facilitate its Degradation by Zheng, Yuan, Qu, Jing, Xue, Fenqin, Zheng, Yan, Yang, Bo, Chang, Yongchang, Yang, Hui, Zhang, Jianliang

“…Parkinson’s disease (PD) is one of the most prevalent forms of synucleinopathies, and it is characterized neuropathologically by the presence of intracellular…”
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The Molecular Mechanism of Alpha-Synuclein Dependent Regulation of Protein Phosphatase 2A Activity by Qu, Jing, Yan, Hongxia, Zheng, Yuan, Xue, Fenqin, Zheng, Yan, Fang, Hongjuan, Chang, Yongchang, Yang, Hui, Zhang, Jianliang

“…Background/Aims: Alpha-synuclein (α-Syn) is a neuronal protein that is highly implicated in Parkinson’s disease (PD), and protein phosphatase 2A (PP2A) is an…”
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Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor by Zhang, Qinhui, Du, Yingjie, Zhang, Jianliang, Xu, Xiaojun, Xue, Fenqin, Guo, Cong, Huang, Yao, Lukas, Ronald J, Chang, Yongchang

“…The α7nicotinic receptor (nAChR) is a major subtype of the nAChRs in the central nervous system, and the receptor plays an important role in brain function. In…”
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Functional rundown of gamma-aminobutyric acidA receptors in human hypothalamic hamartomas by Li, Guohui, Yang, Kechun, Zheng, Chao, Liu, Qiang, Chang, Yongchang, Kerrigan, John F., Wu, Jie

“…Objective Human hypothalamic hamartomas (HHs) are highly associated with treatment‐resistant gelastic seizures. HHs are intrinsically epileptogenic, although…”
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Endothelial cell-specific molecule 2 (ECSM2) localizes to cell-cell junctions and modulates bFGF-directed cell migration via the ERK-FAK pathway by Shi, Chunwei, Lu, Jia, Wu, Wen, Ma, Fanxin, Georges, Joseph, Huang, Hanju, Balducci, James, Chang, Yongchang, Huang, Yao

“…Despite its first discovery by in silico cloning of novel endothelial cell-specific genes a decade ago, the biological functions of endothelial cell-specific…”
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Cocaine Directly Inhibits α6-Containing Nicotinic Acetylcholine Receptors in Human SH-EP1 Cells and Mouse VTA DA Neurons by Chen, Dejie, Gao, Fenfei, Ma, Xiaokuang, Eaton, Jason Brek, Huang, Yuanbing, Gao, Ming, Chang, Yongchang, Ma, Zegang, Der-Ghazarian, Taleen, Neisewander, Janet, Whiteaker, Paul, Wu, Jie, Su, Quanxi

“…Alpha6-containing nicotinic acetylcholine receptors are primarily found in neurons of the midbrain dopaminergic (DA) system, suggesting these receptors are…”
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Evolutionarily Conserved Allosteric Network in the Cys Loop Family of Ligand-gated Ion Channels Revealed by Statistical Covariance Analyses by Chen, Yonghui, Reilly, Kevin, Chang, Yongchang

“…The Cys loop family of ligand-gated ion channels mediate fast synaptic transmission for communication between neurons. They are allosteric proteins, in which…”
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GABAA receptor‐mediated activation of L‐type calcium channels induces neuronal excitation in surgically resected human hypothalamic hamartomas by Kim, Do Young, Fenoglio, Kristina A., Simeone, Timothy A., Coons, Stephen W., Wu, Jie, Chang, Yongchang, Kerrigan, John F., Rho, Jong M.

“…Summary Purpose: The human hypothalamic hamartoma (HH) is a rare, intrinsically epileptogenic lesion associated with gelastic seizures, but the underlying…”
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K+ channel openers restore verapamil-inhibited lung fluid resolution and transepithelial ion transport by Han, Dong-Yun, Nie, Hong-Guang, Gu, Xiu, Nayak, Ramesh C, Su, Xue-Feng, Fu, Jian, Chang, Yongchang, Rao, Vijay, Ji, Hong-Long

“…Lung epithelial Na+ channels (ENaC) are regulated by cell Ca2+ signal, which may contribute to calcium antagonist-induced noncardiogenic lung edema. Although…”
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GABAA receptor-mediated excitation in dissociated neurons from human hypothalamic hamartomas by Wu, Jie, DeChon, Jamie, Xue, Fenqin, Li, Guohui, Ellsworth, Kevin, Gao, Ming, Liu, Qiang, Yang, Kechun, Zheng, Chao, He, Ping, Tu, Jianglong, Kim, Do Young, Rho, Jong M., Rekate, Harold, Kerrigan, John F., Chang, Yongchang

“…The cellular mechanisms underlying intrinsic epileptogenesis in human hypothalamic hamartoma (HH) are unknown. We previously reported that HH tissue is…”
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Mechanism of Allosteric Modulation of the Cys-loop Receptors by Chang, Yongchang, Huang, Yao, Whiteaker, Paul

“…The cys-loop receptor family is a major family of neurotransmitter-operated ion channels. They play important roles in fast synaptic transmission, controlling…”
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Structural and functional characterization of two alternative splicing variants of mouse Endothelial Cell-Specific Chemotaxis Regulator (ECSCR) by Wu, Wen, Shi, Chunwei, Ma, Fanxin, Balducci, James, Huang, Hanju, Ji, Hong-Long, Chang, Yongchang, Huang, Yao

“…Endothelial cells (ECs) that line the lumen of blood vessels are important players in blood vessel formation, and EC migration is a key component of the…”
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Desensitization Mechanism of GABA Receptors Revealed by Single Oocyte Binding and Receptor Function by Chang, YongChang, Ghansah, Emmanuel, Chen, Yonghui, Ye, Jiawei, Weiss, David S

“…Prolonged exposure of most fast neurotransmitter-operated ion channels to agonist drives the receptors into a nonfunctional, or desensitized, state. Despite…”
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Growth Hormone Alters Epidermal Growth Factor Receptor Binding Affinity via Activation of Extracellular Signal-Regulated Kinases in 3T3-F442A Cells by Huang, Yao, Chang, Yongchang, Wang, Xiangdong, Jiang, Jing, Frank, Stuart J

“…Epidermal growth factor receptor (EGFR) is a transmembrane protein that binds EGF in its extracellular domain and initiates signaling via intrinsic tyrosine…”
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Mechanism of action of benzodiazepines on GABAA receptors by Campo‐Soria, Claudia, Chang, Yongchang, Weiss, David S

“…1 Wild‐type and mutant α1β2γ2 GABAA receptors were expressed in Xenopus laevis oocytes and examined using the two‐electrode voltage clamp. 2 Dose–response…”
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Positive allosteric modulation by ultraviolet irradiation on GABAA, but not GABAC, receptors expressed in Xenopus oocytes by Chang, Yongchang, Xie, Yi, Weiss, David S.

“…Recombinant rat GABA A (α1β2, α1β2γ2, β2γ2) and human GABA C (ρ1) receptors were expressed in Xenopus oocytes to examine the effect of ultraviolet (UV)…”
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Mapping the contribution of the C-linker domain to gating polarity in CNBD channels by Lin, Jenna L, Chang, Yongchang, Tewari, Debanjan, Cowgill, John, Chanda, Baron

“…Ion channels of the cyclic nucleotide-binding domain (CNBD) family play a crucial role in the regulation of key biological processes, such as photoreception…”
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