Search Results - "Yong-Mi Kim"

A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity by Khan, Sajid, Zhang, Xuan, Lv, Dongwen, Zhang, Qi, He, Yonghan, Zhang, Peiyi, Liu, Xingui, Thummuri, Dinesh, Yuan, Yaxia, Wiegand, Janet S., Pei, Jing, Zhang, Weizhou, Sharma, Abhisheak, McCurdy, Christopher R., Kuruvilla, Vinitha M., Baran, Natalia, Ferrando, Adolfo A., Kim, Yong-mi, Rogojina, Anna, Houghton, Peter J., Huang, Guangcun, Hromas, Robert, Konopleva, Marina, Zheng, Guangrong, Zhou, Daohong

“…B-cell lymphoma extra large (BCL-X L ) is a well-validated cancer target. However, the on-target and dose-limiting thrombocytopenia limits the use of BCL-X L…”
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Targeting integrins in drug‐resistant acute myeloid leukaemia by Ogana, Heather A., Hurwitz, Samantha, Wei, Nathan, Lee, Eliana, Morris, Kayla, Parikh, Karina, Kim, Yong‐Mi

“…Acute myeloid leukaemia (AML) continues to have a poor prognosis, warranting new therapeutic strategies. The bone marrow (BM) microenvironment consists of…”
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Wnt/Catenin Signaling in Adult Stem Cell Physiology and Disease by Ring, Alexander, Kim, Yong-Mi, Kahn, Michael

“…Wnt signaling plays an important role in development and disease. In this review we focus on the role of the canonical Wnt signaling pathway in somatic stem…”
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Targeting PI3K Signaling in Acute Lymphoblastic Leukemia by Sanchez, Vanessa Edna, Nichols, Cydney, Kim, Hye Na, Gang, Eun Ji, Kim, Yong-Mi

“…Adhesion of acute lymphoblastic leukemia (ALL) cells to bone marrow stroma cells triggers intracellular signals regulating cell-adhesion-mediated drug…”
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Minimal Residual Disease Detection in Acute Lymphoblastic Leukemia by Kruse, Aaron, Abdel-Azim, Nour, Kim, Hye Na, Ruan, Yongsheng, Phan, Valerie, Ogana, Heather, Wang, William, Lee, Rachel, Gang, Eun Ji, Khazal, Sajad, Kim, Yong-Mi

“…Minimal residual disease (MRD) refers to a chemotherapy/radiotherapy-surviving leukemia cell population that gives rise to relapse of the disease. The…”
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Wnt Signaling in Leukemia and Its Bone Marrow Microenvironment by Ruan, Yongsheng, Kim, Hye Na, Ogana, Heather, Kim, Yong-Mi

“…Leukemia is an aggressive hematologic neoplastic disease. Therapy-resistant leukemic stem cells (LSCs) may contribute to the relapse of the disease. LSCs are…”
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CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression by Fousek, Kristen, Watanabe, Junji, Joseph, Sujith K., George, Ann, An, Xingyue, Byrd, Tiara T., Morris, Jessica S., Luong, Annie, Martínez-Paniagua, Melisa A., Sanber, Khaled, Navai, Shoba A., Gad, Ahmed Z., Salsman, Vita S., Mathew, Pretty R., Kim, Hye Na, Wagner, Dimitrios L., Brunetti, Lorenzo, Jang, Albert, Baker, Matthew L., Varadarajan, Navin, Hegde, Meenakshi, Kim, Yong-Mi, Heisterkamp, Nora, Abdel-Azim, Hisham, Ahmed, Nabil

“…Chimeric antigen receptor (CAR) T-cells targeting CD19 demonstrate remarkable efficacy in treating B-lineage acute lymphoblastic leukemia (BL-ALL), yet up to…”
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Cadherins, Selectins, and Integrins in CAM-DR in Leukemia by Kim, Hye Na, Ruan, Yongsheng, Ogana, Heather, Kim, Yong-Mi

“…The interaction between leukemia cells and the bone microenvironment is known to provide drug resistance in leukemia cells. This phenomenon, called cell…”
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Editorial: Microenvironment and therapy-resistance in leukemias by Friedmann, Rachel, Kim, Yong-Mi, Konopleva, Marina

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Editorial: Women in pediatric oncology Vol II: 2022 by Kim, Yong-Mi, Kitlinska, Joanna B

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Editorial: New immunotherapeutic and pharmacological targets and strategies in haematological malignancies by Williams, Mark Thomas Shaw, Kim, Yong-Mi, Guzman, Monica L

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BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia by Hurtz, Christian, Hatzi, Katerina, Cerchietti, Leandro, Braig, Melanie, Park, Eugene, Kim, Yong-mi, Herzog, Sebastian, Ramezani-Rad, Parham, Jumaa, Hassan, Müller, Martin C, Hofmann, Wolf-Karsten, Hochhaus, Andreas, Ye, B Hilda, Agarwal, Anupriya, Druker, Brian J, Shah, Neil P, Melnick, Ari M, Müschen, Markus

“…Chronic myeloid leukemia (CML) is induced by the oncogenic BCR-ABL1 tyrosine kinase and can be effectively treated for many years with tyrosine kinase…”
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Altered physical phenotypes of leukemia cells that survive chemotherapy treatment by Ly, Chau, Ogana, Heather, Kim, Hye Na, Hurwitz, Samantha, Deeds, Eric J, Kim, Yong-Mi, Rowat, Amy C

“…Abstract The recurrence of cancer following chemotherapy treatment is a major cause of death across solid and hematologic cancers. In B-cell acute…”
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Characterizing Deformability of Drug Resistant Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells Using Acoustic Tweezers by Liu, Hsiao-Chuan, Gang, Eun Ji, Kim, Hye Na, Lim, Hae Gyun, Jung, Hayong, Chen, Ruimin, Abdel-Azim, Hisham, Shung, K. Kirk, Kim, Yong-Mi

“…The role of cell mechanics in cancer cells is a novel research area that has resulted in the identification of new mechanisms of therapy resistance. Single…”
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The Wnt signaling pathway in cancer by Duchartre, Yann, Kim, Yong-Mi, Kahn, Michael

“…Abstract The Wnt signaling pathway is critically involved in both the development and homeostasis of tissues via regulation of their endogenous stem cells…”
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Effects of CD49d-targeted antisense-oligonucleotide on α4 integrin expression and function of acute lymphoblastic leukemia cells: Results of in vitro and in vivo studies by Duchartre, Yann, Bachl, Stefanie, Kim, Hye Na, Gang, Eun Ji, Lee, Solah, Liu, Hsiao-Chuan, Shung, Kirk, Xu, Ruth, Kruse, Aaron, Tachas, George, Bonig, Halvard, Kim, Yong-Mi

“…We recently demonstrated the effectiveness of blocking CD49d with anti-functional antibodies or small molecule inhibitors as a rational targeted approach to…”
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Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy by Hsieh, Yao-Te, Gang, Eun Ji, Geng, Huimin, Park, Eugene, Huantes, Sandra, Chudziak, Doreen, Dauber, Katrin, Schaefer, Paul, Scharman, Carlton, Shimada, Hiroyuki, Shojaee, Seyedmehdi, Klemm, Lars, Parameswaran, Reshmi, Loh, Mignon, Kang, Eun-Suk, Koo, Hong Hoe, Hofmann, Wolf-Karsten, Andrade, Jacob, Crooks, Gay M., Willman, Cheryl L., Müschen, Markus, Papayannopoulou, Thalia, Heisterkamp, Nora, Bönig, Halvard, Kim, Yong-Mi

“…Bone marrow (BM) provides chemoprotection for acute lymphoblastic leukemia (ALL) cells, contributing to lack of efficacy of current therapies. Integrin alpha4…”
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Phosphoflow-Based Evaluation of Mek Inhibitors as Small-Molecule Therapeutics for B-Cell Precursor Acute Lymphoblastic Leukemia by George, Aswathi A, Paz, Helicia, Fei, Fei, Kirzner, Jonathan, Kim, Yong-Mi, Heisterkamp, Nora, Abdel-Azim, Hisham

“…Upstream mutations that lead to constitutive activation of Erk in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) are relatively common. In the era of…”
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Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition by Saito, Kaori, Zhang, Qi, Yang, Haeun, Yamatani, Kotoko, Ai, Tomohiko, Ruvolo, Vivian, Baran, Natalia, Cai, Tianyu, Ma, Helen, Jacamo, Rodrigo, Kuruvilla, Vinitha, Imoto, Junichi, Kinjo, Sonoko, Ikeo, Kazuho, Moriya, Kaori, Suzuki, Koya, Miida, Takashi, Kim, Yong-Mi, Vellano, Christopher P., Andreeff, Michael, Marszalek, Joseph R., Tabe, Yoko, Konopleva, Marina

“…Acute myeloid leukemia (AML) cells are highly dependent on oxidative phosphorylation (OxPhos) for survival, and they continually adapt to fluctuations in…”
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Professional versus Political Contexts: Institutional Mitigation and the Transaction Cost Heuristic in Information Systems Outsourcing by Miranda, Shaila M., Kim, Yong-Mi

“…IS research has considered the outsourcing decision from the perspective of transaction cost economics (TCE) and institutional theory. In this research, we…”
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