Search Results - "Yong Taik Lim"
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Multivalent Polymer Nanocomplex Targeting Endosomal Receptor of Immune Cells for Enhanced Antitumor and Systemic Memory Response
Published in Angewandte Chemie International Edition (06-07-2015)“…We have designed and synthesized linear polymer‐based nanoconjugates and nanocomplexes bearing multivalent immunostimulatory ligands and also demonstrated that…”
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A Designer Scaffold with Immune Nanoconverters for Reverting Immunosuppression and Enhancing Immune Checkpoint Blockade Therapy
Published in Advanced materials (Weinheim) (01-10-2019)“…Current cancer immunotherapy based on immune checkpoint blockade (ICB) still suffers from low response rate and systemic toxicity. To overcome the limitation,…”
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Nanoengineered Immune Niches for Reprogramming the Immunosuppressive Tumor Microenvironment and Enhancing Cancer Immunotherapy
Published in Advanced materials (Weinheim) (01-08-2019)“…Cancer immunotherapies that harness the body's immune system to combat tumors have received extensive attention and become mainstream strategies for treating…”
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Noninvasive Assessment of Myocardial Inflammation by Cardiovascular Magnetic Resonance in a Rat Model of Experimental Autoimmune Myocarditis
Published in Circulation (New York, N.Y.) (29-05-2012)“…Limited availability of noninvasive and biologically precise diagnostic tools poses a challenge for the evaluation and management of patients with myocarditis…”
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Programmed nanoparticles for combined immunomodulation, antigen presentation and tracking of immunotherapeutic cells
Published in Biomaterials (01-01-2014)“…Abstract We report programmed nanoparticles (pNPs) that can tailor the immunotherapeutic function of primary bone marrow-derived dendritic cells (BMDCs) by…”
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The Potential Adjuvanticity of CAvant®SOE for Foot-and-Mouth Disease Vaccine
Published in Vaccines (Basel) (28-09-2021)“…Foot-and-mouth disease (FMD) is a notifiable contagious disease of cloven-hoofed mammals. A high potency vaccine that stimulates the host immune response is…”
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Protective Efficacy and Immunogenicity of Rv0351/Rv3628 Subunit Vaccine Formulated in Different Adjuvants Against Mycobacterium tuberculosis Infection
Published in Immune network (2023)“…Bacillus Calmette-Guerin (BCG) vaccine is the only licensed vaccine for tuberculosis (TB) prevention. Previously, our group demonstrated the vaccine potential…”
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Quantum dot-based protein micro- and nanoarrays for detection of prostate cancer biomarkers
Published in Proteomics (Weinheim) (01-05-2008)“…In this article, we demonstrate the fabrication and detection of cancer protein biochips consisting of micro- and nanoarrays whereby pegylated quantum dots…”
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Syringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence
Published in Nature communications (20-08-2019)“…The low response rate of current cancer immunotherapy suggests the presence of few antigen-specific T cells and a high number of immunosuppressive factors in…”
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Enhanced Cancer Vaccination by In Situ Nanomicelle-Generating Dissolving Microneedles
Published in ACS nano (23-10-2018)“…Efficient delivery of tumor antigens and immunostimulatory adjuvants into lymph nodes is crucial for the maturation and activation of antigen-presenting cells…”
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Lyophilizable and Multifaceted Toll-like Receptor 7/8 Agonist-Loaded Nanoemulsion for the Reprogramming of Tumor Microenvironments and Enhanced Cancer Immunotherapy
Published in ACS nano (26-11-2019)“…The low therapeutic efficacy of current cancer immunotherapy is related to nonimmunogenic and immunosuppressive tumor microenvironments (TMEs). To overcome…”
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Antioxidant effect of estrogen on bovine aortic endothelial cells
Published in The Journal of steroid biochemistry and molecular biology (01-10-2009)“…This study discussed the role of estrogen as an antioxidant in the damage of vascular endothelial cells. We treated bovine aortic endothelial cells (bAEC)…”
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13
Magnetophoretic circuits for digital control of single particles and cells
Published in Nature communications (14-05-2014)“…The ability to manipulate small fluid droplets, colloidal particles and single cells with the precision and parallelization of modern-day computer hardware has…”
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Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles
Published in Toxicology and applied pharmacology (01-04-2009)“…In general, gold nanoparticles are recognized as being as nontoxic. Still, there have been some reports on their toxicity, which has been shown to depend on…”
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Prebiotic Effects of Poly-Gamma-Glutamate on Bacterial Flora in Murine Gut
Published in Journal of microbiology and biotechnology (28-02-2017)“…Prebiotics improve the growth or activities of specific microbial genera and species in the gut microbiota in order to confer health benefits to the host. In…”
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Kinetics reshape antitumor immunity: Timing, duration, and combination are of importance for successful cancer immunotherapy
Published in Clinical and translational medicine (01-09-2023)“…THE LIMITATION OF CURRENT CANCER IMMUNOTHERAPY The current immune checkpoint blockade therapy (ICBT) still has a low response rate, which ranges from…”
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Simultaneous in vivo tracking of dendritic cells and priming of an antigen-specific immune response
Published in Biomaterials (01-09-2011)“…Abstract We report the fabrication of a one-pot antigen system that delivers antigen to dendritic cells (DCs) and tracks their in vivo migration after…”
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Synthesis and Characterization of a Photoluminescent Nanoparticle Based on Fullerene-Silica Hybridization
Published in Angewandte Chemie International Edition (06-07-2009)“…Bright lights: Fullerene–silica hybrid nanoparticles have bright photoluminescence, high photostability, and low cytotoxicity, which are assets for bioimaging…”
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Synthesis and High Performance of Magnetofluorescent Polyelectrolyte Nanocomposites as MR/Near-Infrared Multimodal Cellular Imaging Nanoprobes
Published in ACS nano (25-10-2011)“…Here, we describe an easy but robust chemical strategy to synthesize high-performance magnetic resonance (MR)/near-infrared (NIR) multimodal imaging…”
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Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping
Published in Nature biotechnology (01-01-2004)“…The use of near-infrared or infrared photons is a promising approach for biomedical imaging in living tissue. This technology often requires exogenous contrast…”
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