Search Results - "Yong‐Long, Han"

Serum and urine metabolomics study reveals a distinct diagnostic model for cancer cachexia by Yang, Quan‐Jun, Zhao, Jiang‐Rong, Hao, Juan, Li, Bin, Huo, Yan, Han, Yong‐Long, Wan, Li‐Li, Li, Jie, Huang, Jinlu, Lu, Jin, Yang, Gen‐Jin, Guo, Cheng

“…Background Cachexia is a multifactorial metabolic syndrome with high morbidity and mortality in patients with advanced cancer. The diagnosis of cancer cachexia…”
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Selumetinib Attenuates Skeletal Muscle Wasting in Murine Cachexia Model through ERK Inhibition and AKT Activation by Quan-Jun, Yang, Yan, Huo, Yong-Long, Han, Li-Li, Wan, Jie, Li, Jin-Lu, Huang, Jin, Lu, Peng-Guo, Chen, Run, Gan, Cheng, Guo

“…Cancer cachexia is a multifactorial syndrome affecting the skeletal muscle. Previous clinical trials showed that treatment with MEK inhibitor selumetinib…”
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Distinct Metabolic Profile of Inhaled Budesonide and Salbutamol in Asthmatic Children during Acute Exacerbation by Quan‐Jun, Yang, Jian‐Ping, Zhang, Jian‐Hua, Zhang, Yong‐Long, Han, Bo, Xin, Jing‐Xian, Zhang, Bona, Dai, Yuan, Zhang, Cheng, Guo

“…Inhaled budesonide and salbutamol represent the most important and frequently used drugs in asthmatic children during acute exacerbation. However, there is…”
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Effects of diosmetin on nine cytochrome P450 isoforms, UGTs and three drug transporters in vitro by Chen, Jun-Jun, Zhang, Jing-Xian, Zhang, Xiang-Qi, Qi, Mei-Juan, Shi, Mei-Zhi, Yang, Jiao, Zhang, Ke-Zhi, Guo, Cheng, Han, Yong-Long

“…Diosmetin (3′, 5, 7-trihydroxy-4′-methoxyflavone), a natural flavonoid from traditional Chinese herbs, has been used in various medicinal products because of…”
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Scutellarin protects against doxorubicin-induced acute cardiotoxicity and regulates its accumulation in the heart by Sun, Xi-Peng, Wan, Li-Li, Yang, Quan-Jun, Huo, Yan, Han, Yong-Long, Guo, Cheng

“…The clinical use of doxorubicin (DOX) is limited by its dose-dependent cardiotoxicity. The present study investigated the effects of scutellarin against…”
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In Vitro Inhibition of Huanglian [Rhizoma coptidis (L.)] and its Six Active Alkaloids on Six Cytochrome P450 Isoforms in Human Liver Microsomes by Han, Yong‐Long, Yu, Hong‐Liang, Li, Dan, Meng, Xiang‐Le, Zhou, Zhi‐Yong, Yu, Qi, Zhang, Xiao‐You, Wang, Fu‐Jing, Guo, Cheng

“…Huanglian (Rhizoma Coptidis) as a popular herb has been used for the treatment of various diseases such as diarrhea, eye inflammation and women's abdominal…”
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Effects of Danhong injection, a traditional Chinese medicine, on nine cytochrome P450 isoforms in vitro by Zhang, Jing‐Xian, Qi, Mei‐Juan, Shi, Mei‐Zhi, Chen, Jun‐Jun, Zhang, Xiang‐Qi, Yang, Jiao, Zhang, Ke‐Zhi, Han, Yong‐Long, Guo, Cheng

“…Danhong injection (DHI) is made from Salvia miltiorrhiza Bunge. and Carthamus tinctorius L. extract and is widely used in the clinical treatment of…”
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In vitro inhibitory effects of scutellarin on six human/rat cytochrome P450 enzymes and P-glycoprotein by Han, Yong-Long, Li, Dan, Yang, Quan-Jun, Zhou, Zhi-Yong, Liu, Li-Ya, Li, Bin, Lu, Jin, Guo, Cheng

“…Inhibition of cytochrome P450 (CYP) and P-glycoprotein (P-gp) are regarded as the most frequent and clinically important pharmacokinetic causes among the…”
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A sensitive and high-throughput LC-MS/MS method for inhibition assay of seven major cytochrome P450s in human liver microsomes using an in vitro cocktail of probe substrates by Liu, Li-Ya, Han, Yong-Long, Zhu, Jin-Hui, Yu, Qi, Yang, Quan-Jun, Lu, Jin, Guo, Cheng

“…A sensitive and high‐throughput LC‐MS/MS method was established and validated for the simultaneous quantification of seven probe substrate‐derived metabolites…”
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A cross-sectional study on the potential drug-drug interaction risk of COVID-19 patients in hospital by Huang, Liu-Lyu, Jiang, Bo, Han, Yong-Long, Liu, Ying

“…To investigate the incidence of and risk factors for potential drug-drug interactions (DDIs) among elderly patients with corona virus disease 2019 (-COVID-19)…”
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Tongguanteng injection reverses paclitaxel resistance via upregulation of TAB1 expression in ovarian cancer in vitro and in vivo by Kong, Qian-Wen, Yang, Jiao, Li, Dan, Ding, Ya-Wei, Hu, Yu-Jie, Xue, Xiao-Chuan, Shi, Mei-Zhi, Jiang, Bo, Zhou, Yang-Yun, Zhang, Min, Hu, Jiu-Dong, Guo, Cheng, Chen, Jun-Jun, Han, Yong-Long

“…ETHNOPHARMACOLOGICAL RELEVANCETongguanteng injection (TGT), the water extract from the stem of the Traditional Chinese hebal medicine of Marsdenia tenacissima…”
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Effect of Xiao-Ai-Ping injection on paclitaxel pharmacokinetics in rats by LC–MS/MS method by Shi, Mei-Zhi, Xing, Ting-Yu, Chen, Jun-Jun, Jiang, Bo, Xiao, Xiao, Yang, Jiao, Zhu, Jiang, Guo, Cheng, Hu, Jiu-Dong, Han, Yong-Long

“…[Display omitted] •LC–MS/MS method was developed and validated to simultaneously quantify paclitaxel and 3′-p-hydroxypaclitaxel in rat plasma.•The quantitation…”
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Xiaoaiping injection enhances paclitaxel efficacy in ovarian cancer via pregnane X receptor and its downstream molecules by Zhang, Xiang-Qi, Ding, Ya-Wei, Chen, Jun-Jun, Xiao, Xiao, Zhang, Wei, Zhou, Li, Kong, Qian-Wen, Shi, Mei-Zhi, Yang, Jiao, Jiang, Bo, Guo, Cheng, Han, Yong-Long

“…Xiaoaiping injection, a traditional Chinese medical injection extracted from root of Marsdenia tenacissima (Roxb.) Moon, has been exclusively used on curing…”
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Nilotinib reverses ABCB1/P-glycoprotein-mediated multidrug resistance but increases cardiotoxicity of doxorubicin in a MDR xenograft model by Zhou, Zhi-yong, Wan, Li-li, Yang, Quan-jun, Han, Yong-long, Li, Dan, Lu, Jin, Guo, Cheng

“…•Nilotinib can reverse P-gp-mediated multidrug resistance of DOX in vitro and in vivo.•Co-administration of nilotinib increase the accumulation of DOX and…”
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Evaluation of impact of Herba Erigerontis injection, a Chinese herbal prescription, on rat hepatic cytochrome P450 enzymes by cocktail probe drugs by Han, Yong-Long, Li, Dan, Ren, Bin, Jing, Guang-Ping, Meng, Xiang-Le, Zhou, Zhi-Yong, Yu, Qi, Li, Yan, Wan, Li-Li, Guo, Cheng

“…Herba Erigerontis injection (HEI), one of the most popular herbal prescription in China, is made from the aqueous extracts of Erigeron breviscapus whole plant…”
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Tongguanteng injection exerts anti-osteosarcoma effects through the ER stress-associated IRE1/CHOP pathway by Xue, Xiao-Chuan, Zhou, Yang-Yun, Xu, Ling-Yan, Wei, Lan-Yi, Hu, Yu-Jie, Yang, Jiao, Zhang, Xiang-Qi, Wang, Meng-Yue, Han, Yong-Long, Chen, Jun-Jun

“…Background In China, Tongguanteng injection (TGT) is widely used in the treatment or adjuvant treatment of various types of cancer. However, the effect and…”
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Pim-2 Modulates Aerobic Glycolysis and Energy Production during the Development of Colorectal Tumors by Zhang, Xue-hui, Yu, Hong-liang, Wang, Fu-jing, Han, Yong-long, Yang, Wei-liang

“…Tumor cells have higher rates of glucose uptake and aerobic glycolysis to meet energy demands for proliferation and metastasis. The characteristics of…”
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Evaluation of the pharmacokinetics and cardiotoxicity of doxorubicin in rat receiving nilotinib by Zhou, Zhi-yong, Wan, Li-li, Yang, Quan-jun, Han, Yong-long, Li, Yan, Yu, Qi, Guo, Cheng, Li, Xiao

“…Doxorubicin (DOX) is a potent chemotherapy drug with a narrow therapeutic window. Nilotinib, a small-molecule Bcr-Abl tyrosine kinase inhibitor, was reported…”
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Inhibitory effects of limonin on six human cytochrome P450 enzymes and P-glycoprotein in vitro by Han, Yong-Long, Yu, Hong-Liang, Li, Dan, Meng, Xiang-Le, Zhou, Zhi-Yong, Yu, Qi, Zhang, Xiao-You, Wang, Fu-Jing, Guo, Cheng

“…Inhibition of human CYP3A4 by limonin (100, 30, 10, 3.0, 1.0, 0.3, 0.1, and 0.03μM) using the enzyme/substrate cocktail method. Potent inhibition of CYP3A4 by…”
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Mechanism of Huachansu Injection against colorectal cancer based on network pharmacology and cellular experimental by Meng, Zhao-Yang, Zhao, Juan, Zhu, Qin-Fang, Xiang, Dan-Feng, Meng, Jing-Jing, Chen, Jun-Jun, Jiang, Bo, Hu, Yu-Jie, Xu, Ling-Yan, Zhang, Xiang-Qi, Zou, Huan, Han, Yong-Long

“…This study aimed to elucidate the mechanism of Huachansu Injection(HCSI) against colorectal cancer(CRC) using network pharmacology, molecular docking…”
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