Search Results - "Yong, VW"

Metalloproteinases: Mediators of Pathology and Regeneration in the CNS by Yong, V. Wee

“…The matrix metalloproteinases and related A disintegrin and metalloproteinase enzymes are implicated in various diseases of the nervous system. However,…”
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Differential mechanisms of action of interferon-β and glatiramer acetate in MS by WEE YONG, V

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The promise of minocycline in neurology by Yong, V Wee, Wells, Jennifer, Giuliani, Fabrizio, Casha, Steven, Power, Christopher, Metz, Luanne M

“…The capacity of minocycline to alleviate disease for several neurological disorders in animals is increasingly being recognised. Indeed, that one drug alone…”
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Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines by Balasingam, V, Tejada-Berges, T, Wright, E, Bouckova, R, Yong, VW

“…Reactive astrogliosis is a characteristic response of astrocytes to inflammation and trauma of the adult CNS. To assess the hypothesis that cytokines from…”
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Omarigliptin Protects the Integrity of the Blood-Brain Barrier After Intracerebral Hemorrhage in Mice by Zhang, Yan, Liu, Yang, Zhang, Xiangyu, Yong, V Wee, Xue, Mengzhou

“…Intracerebral hemorrhage (ICH) is a fatal disease without effective treatment. The damage of the blood-brain barrier (BBB) is a key cause of brain edema and…”
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Metalloproteinases in biology and pathology of the nervous system by Yong, V. Wee, Power, Christopher, Forsyth, Peter, Edwards, Dylan R

“…Matrix metalloproteinases (MMPs) have been implicated in several diseases of the nervous system. Here we review the evidence that supports this idea and…”
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Pro‐regenerative properties of cytokine‐activated astrocytes by Liberto, Christina M., Albrecht, P. J., Herx, L. M., Yong, V. W., Levison, S. W.

“…The prevailing view of the astrocytic response to injury is that reactive astrocytes impede the regenerative process by forming scar tissue. As the levels of…”
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Intracerebral hemorrhage induces macrophage activation and matrix metalloproteinages by POWER, Christopher, HENRY, Scot, DEL BIGIO, Marc R, LARSEN, Peter H, CORBETT, Dale, IMAI, Yumi, VOON WEE YONG, PEELING, James

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Targeting leukocyte MMPs and transmigration: Minocycline as a potential therapy for multiple sclerosis by BRUNDULA, Veronika, REWCASTLE, N. Barry, METZ, Luanne M, BERNARD, Claude C, YONG, V. Wee

“…Multiple sclerosis is characterized by the infiltration of leukocytes into the CNS. As matrix metalloproteinases (MMPs) facilitate the passage of leukocytes…”
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Neuroprotection by minocycline facilitates significant recovery from spinal cord injury in mice by Wells, Jennifer E. A., Hurlbert, R. John, Fehlings, Michael G., Yong, V. Wee

“…Acute spinal cord injury (SCI) produces tissue damage that continues to evolve days and weeks after the initial insult, with corresponding functional…”
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A1 Adenosine Receptor Upregulation and Activation Attenuates Neuroinflammation and Demyelination in a Model of Multiple Sclerosis by Tsutsui, Shigeki, Schnermann, Jurgen, Noorbakhsh, Farshid, Henry, Scot, Yong, V. Wee, Winston, Brent W, Warren, Kenneth, Power, Christopher

“…The neuromodulator adenosine regulates immune activation and neuronal survival through specific G-protein-coupled receptors expressed on macrophages and…”
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Matrix Metalloproteinase-9 Facilitates Remyelination in Part by Processing the Inhibitory NG2 Proteoglycan by Larsen, Peter H, Wells, Jennifer E, Stallcup, William B, Opdenakker, Ghislain, Yong, V. Wee

“…Remyelination is a critical repair process that is initiated after a demyelinating insult. The failure to remyelinate contributes to neurological diseases such…”
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Interleukin-1β promotes oligodendrocyte death through glutamate excitotoxicity by Takahashi, Jennifer L., Giuliani, Fabrizio, Power, Christopher, Imai, Yoshinori, Yong, V. Wee

“…Glutamate excitotoxicity is implicated in the progressive loss of oligodendrocytes in multiple sclerosis, but how glutamate metabolism is dysregulated in the…”
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Association between the cerebral inflammatory and matrix metalloproteinase responses after severe traumatic brain injury in humans by Roberts, Derek J, Jenne, Craig N, Léger, Caroline, Kramer, Andreas H, Gallagher, Clare N, Todd, Stephanie, Parney, Ian F, Doig, Christopher J, Yong, V Wee, Kubes, Paul, Zygun, David A

“…An increasing number of preclinical investigations have suggested that the degree of expression of the matrix metalloproteinase (MMP) family of endopeptidases…”
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Minocycline attenuates T cell and microglia activity to impair cytokine production in T cell-microglia interaction by Giuliani, Fabrizio, Hader, Walter, Yong1, V. Wee

“…Minocycline, a tetracycline with anti‐inflammatory properties, has been reported to down‐regulate the activity of microglia, whose activation occurs in…”
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Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis by Bar‐Or, Amit, Nuttall, Robert K., Duddy, Martin, Alter, Andrea, Kim, Ho Jin, Ifergan, Igal, Pennington, Caroline J., Bourgoin, Pierre, Edwards, Dylan R., Yong, V. Wee

“…Matrix metalloproteinases (MMPs) are implicated in multiple sclerosis where one of their roles may be to facilitate the transmigration of circulating…”
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Myelin Formation during Development of the CNS Is Delayed in Matrix Metalloproteinase-9 and -12 Null Mice by Larsen, Peter H, DaSilva, Angelika Goncalves, Conant, Katherine, Yong, V. Wee

“…The matrix metalloproteinases (MMPs) are implicated in several activities within the nervous system. Although many functions of abnormally elevated MMPs are…”
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Vulnerability of Human Neurons to T Cell-Mediated Cytotoxicity by Giuliani, Fabrizio, Goodyer, Cynthia G, Antel, Jack P, Yong, V. Wee

“…Axonal and neuronal loss occurs in inflammatory diseases of the CNS such as multiple sclerosis. The cause of the loss remains unclear. We report that…”
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Interferon beta in the treatment of multiple sclerosis : Mechanisms of action by WEE YONG, V, CHABOT, S, STUVE, O, WILLIAMS, G

“…Interferon beta (IFN-beta) has been shown in several clinical trials to have efficacy in MS. Its mechanism of action, however, remains unclear. In this review,…”
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Glatiramer acetate in combination with minocycline in patients with relapsing—remitting multiple sclerosis: results of a Canadian, multicenter, double-blind, placebo-controlled trial by Metz, LM, Li, D., Traboulsee, A., Myles, ML, Duquette, P., Godin, J., Constantin, M., Yong, VW

“…Minocycline is proposed as an add-on therapy to improve the efficacy of glatiramer acetate in relapsing—remitting multiple sclerosis. The effect of minocycline…”
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