Search Results - "Yong, Koh Meng Aw"

Heterogeneity at the invasion front of triple negative breast cancer cells by Aw Yong, Koh Meng, Ulintz, Peter J., Caceres, Sara, Cheng, Xu, Bao, Liwei, Wu, Zhifen, Jiagge, Evelyn M., Merajver, Sofia D.

“…Identifying better predictive and prognostic biomarkers for the diagnosis and treatment of triple negative breast cancer (TNBC) is complicated by tumor…”
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Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells by Xue, Xufeng, Sun, Yubing, Resto-Irizarry, Agnes M., Yuan, Ye, Aw Yong, Koh Meng, Zheng, Yi, Weng, Shinuo, Shao, Yue, Chai, Yimin, Studer, Lorenz, Fu, Jianping

“…Classic embryological studies have successfully applied genetics and cell biology principles to understand embryonic development. However, it remains…”
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Probing the invasiveness of prostate cancer cells in a 3D microfabricated landscape by Liu, Liyu, Sun, Bo, Pedersen, Jonas N, Aw Yong, Koh-Meng, Getzenberg, Robert H, Stone, Howard A, Austin, Robert H

“…The metastatic invasion of cancer cells from primary tumors to distant ecological niches, rather than the primary tumors, is the cause of much cancer mortality…”
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Tracking the tumor invasion front using long-term fluidic tumoroid culture by Aw Yong, Koh Meng, Li, Zida, Merajver, Sofia D., Fu, Jianping

“…The analysis of invading leader cells at the tumor invasion front is of significant interest as these cells may possess a coordinated functional and molecular…”
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Correlation of Sprouty1 and Jagged1 With Aggressive Prostate Cancer Cells With Different Sensitivities to Androgen Deprivation by Terada, Naoki, Shiraishi, Takumi, Zeng, Yu, Aw-Yong, Koh-Meng, Mooney, Steven M., Liu, Zhi, Takahashi, Sayuri, Luo, Jun, Lupold, Shawn E., Kulkarni, Prakash, Getzenberg, Robert H.

“…ABSTRACT Prostate cancer is a heterogeneous disease and thus, it is important to understand whether among the heterogeneous collection of cell types,…”
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Microfluidic Blood Cell Sorting: Now and Beyond by Yu, Zeta Tak For, Aw Yong, Koh Meng, Fu, Jianping

“…Blood plays an important role in homeostatic regulation with each of its cellular components having important therapeutic and diagnostic uses. Therefore,…”
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Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche by Shao, Yue, Taniguchi, Kenichiro, Gurdziel, Katherine, Townshend, Ryan F., Xue, Xufeng, Yong, Koh Meng Aw, Sang, Jianming, Spence, Jason R., Gumucio, Deborah L., Fu, Jianping

“…The control of biophysical cues during the culture of human pluripotent stem cells on biomaterial substrates can be used to replicate the in vivo amniogenic…”
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Mechanotransduction-Induced Reversible Phenotypic Switching in Prostate Cancer Cells by Aw Yong, Koh Meng, Sun, Yubing, Merajver, Sofia D., Fu, Jianping

“…Phenotypic plasticity is posed to be a vital trait of cancer cells such as circulating tumor cells, allowing them to undergo reversible or irreversible…”
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Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells by Sun, Yubing, Yong, Koh Meng Aw, Villa-Diaz, Luis G., Zhang, Xiaoli, Chen, Weiqiang, Philson, Renee, Weng, Shinuo, Xu, Haoxing, Krebsbach, Paul H., Fu, Jianping

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Morphological Effects on Expression of Growth Differentiation Factor 15 (GDF15), a Marker of Metastasis by Aw Yong, Koh Meng, Zeng, Yu, Vindivich, Donald, Phillip, Jude M., Wu, Pei-Hsun, Wirtz, Denis, Getzenberg, Robert H.

“…Cancer cells typically demonstrate altered morphology during the various stages of disease progression as well as metastasis. While much is known about how…”
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1405 Comparative analysis of complete blood count, serum chemistry and immune phenotype between SRG and CD rats by Aw Yong, Koh Meng, Eberle, Christoph, Dowdy, Christopher, Brenzel, Chris, Begemann, Diane, Walton, Grace, Noto, Fallon, Festin, Stephen

“…BackgroundThe number of cancer drugs in development has doubled over the last decade, increasing the need for well characterized immunodeficient animal models…”
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A Bioreactor for 3D In Vitro Modeling of the Mechanical Stimulation of Osteocytes by Aw Yong, Koh Meng, Horst, Eric, Neale, Dylan, Royzenblat, Sonya, Lahann, Joerg, Greineder, Colin, Weivoda, Megan, Mehta, Geeta, Keller, Evan T

“…The bone is a mechanosensitive organ that is also a common metastatic site for prostate cancer. However, the mechanism by which the tumor interacts with the…”
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Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells by Sun, Yubing, Yong, Koh Meng Aw, Villa-Diaz, Luis G., Zhang, Xiaoli, Chen, Weiqiang, Philson, Renee, Weng, Shinuo, Xu, Haoxing, Krebsbach, Paul H., Fu, Jianping

“…Although human pluripotent stem cells (hPSCs) can be used to regenerate neural tissues, inefficient protocols and poorly defined culture conditions have…”
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Abstract 5769: Modeling the tumor invasion front using 3D fluidic tumoroid culture of cancer cells by Yong, Koh Meng Aw, Oliver, Christopher, Altemus, Megan, Wu, Zhi Fen, Merajver, Sofia

“…To realize the promise of precision medicine, it is important to integrate phenotypic assessment of cell populations to genomic data. The analysis of invading…”
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Synthetic micro/nanoengineered tools to study mechanobiology and its regulatory role for human pluripotent stem cells by Fu, Jianping, Sun, Yubing, Yong, Koh Meng Aw

“…In this talk, I will discuss our recent effort using synthetic micro/nanoengineered tools to study mechano-sensitive and -responsive behaviors of human…”
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Abstract 51: The SRG immunodeficient rat demonstrates utility across multiple tumor types of different organ origins by Yong, Koh Meng Aw, Eberle, Christoph, Dowdy, Christopher, Walton, Grace, Begemann, Diane, Brenzel, Christopher, Noto, Fallon, Festin, Stephen

“…Introduction The number of approved cancer drugs as well as those in development have doubled over the last decade. With this increase comes a need for…”
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Abstract 1453: Development and evaluation of subcutaneous and orthotopic PC3M metastatic prostate cancer xenograft model in SRG rats for therapeutic assessment by Draheim, Kyle, Rainbolt, Elizabeth, John, Bincy, Clouse, Cara, Shinn, Karyn, Avery, Justin, Yong, Koh Meng Aw, Hall, Chassidy, Fadden, Patrick, Avrutskaya, Anya

“…Introduction: Prostate cancer is the most prevalent cause of cancer deaths in American males after lung cancer. The establishment of clinically relevant…”
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Microfluidic Blood Cell Preparation: Now and Beyond by Yu, Zeta Tak For, Yong, Koh Meng Aw, Fu, Jianping

“…Blood plays an important role in homeostatic regulation with each of its cellular components having important therapeutic and diagnostic uses. Therefore,…”
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Abstract 4183: Utility of the highly immunodeficient SRG rat for combined drug efficacy, pharmacokinetics, and toxicology studies in tumor-bearing animals by Begemann, Diane, Dunn, Cynthia, Robertson, Darrell, Keach, Lauren, Baldwin, Emily, Walton, R. Grace, Van Engelenburg, Alex, Durrant, Jessica, Healy, Laura, Yong, Koh Meng Aw, Schlosser, Michael J., Noto, Fallon K.

“…Immunodeficient rodents are vital pre-clinical disease models. Historically, immunodeficient mice have been standard for hosting human cell and tissue…”
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Abstract 5188: Altering cell attachment to growth substrate up-regulates growth differentiation factor 15 (GDF15) expression by Yong, Koh Meng Aw, Zeng, Yu, Vindivich, Donald, Getzenberg, Robert

“…Cell attachment to the extracellular environment is critical in determining cell fate. When normal cells lose attachment, they undergo anoikis. Cancer cells…”
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