Search Results - "Yonemori, Kazuko"

Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging by Niida, Ayumu, Sasaki, Shigekazu, Yonemori, Kazuko, Sameshima, Tomoya, Yaguchi, Masahiro, Asami, Taiji, Sakamoto, Kotaro, Kamaura, Masahiro

“…[Display omitted] •K-Ras(G12D) is selectively inhibited by a cyclic peptide, KRpep-2d.•Alanine scanning was used to determine the amino acids critical to this…”
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Farnesoid X receptor antagonist exacerbates dyslipidemia in mice by Amano, Yuichiro, Yamakawa, Hiroko, Yonemori, Kazuko, Shimada, Mitsuyuki, Tozawa, Ryuichi

“…The effects of farnesoid X receptor (FXR) antagonists on plasma lipid profile in mice have not been investigated thus far. The aim of this study was to…”
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Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents by Imamura, Keisuke, Tomita, Naoki, Kawakita, Youichi, Ito, Yoshiteru, Ono, Kouji, Nii, Noriyuki, Miyazaki, Tohru, Yonemori, Kazuko, Tawada, Michiko, Sumi, Hiroyuki, Satoh, Yoshihiko, Yamamoto, Yukiko, Miyahisa, Ikuo, Sasaki, Masako, Satomi, Yoshinori, Hirayama, Megumi, Nishigaki, Ryuichi, Maezaki, Hironobu

“…[Display omitted] A lead compound A was identified previously as an stearoyl coenzyme A desaturase (SCD) inhibitor during research on potential treatments for…”
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Cryo-EM Structure of K+-Bound hERG Channel Complexed with the Blocker Astemizole by Asai, Tatsuki, Adachi, Naruhiko, Moriya, Toshio, Oki, Hideyuki, Maru, Takamitsu, Kawasaki, Masato, Suzuki, Kano, Chen, Sisi, Ishii, Ryohei, Yonemori, Kazuko, Igaki, Shigeru, Yasuda, Satoshi, Ogasawara, Satoshi, Senda, Toshiya, Murata, Takeshi

“…The hERG channel is a voltage-gated potassium channel involved in cardiac repolarization. Off-target hERG inhibition by drugs has become a critical issue in…”
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Discovery of [cis-3-({(5R)‑5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro‑1H‑inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5H)‑yl}carbonyl)­cyclobutyl]­acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist by Kono, Mitsunori, Ochida, Atsuko, Oda, Tsuneo, Imada, Takashi, Banno, Yoshihiro, Taya, Naohiro, Masada, Shinichi, Kawamoto, Tetsuji, Yonemori, Kazuko, Nara, Yoshi, Fukase, Yoshiyuki, Yukawa, Tomoya, Tokuhara, Hidekazu, Skene, Robert, Sang, Bi-Ching, Hoffman, Isaac D, Snell, Gyorgy P, Uga, Keiko, Shibata, Akira, Igaki, Keiko, Nakamura, Yoshiki, Nakagawa, Hideyuki, Tsuchimori, Noboru, Yamasaki, Masashi, Shirai, Junya, Yamamoto, Satoshi

“…A series of tetrahydro­naphthyridine derivatives as novel RORγt inverse agonists were designed and synthesized. We reduced the lipophilicity of…”
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Identification of PARP14 inhibitors using novel methods for detecting auto-ribosylation by Yoneyama-Hirozane, Mariko, Matsumoto, Shin-ichi, Toyoda, Yukio, Saikatendu, Kumar Singh, Zama, Yumi, Yonemori, Kazuko, Oonishi, Motomi, Ishii, Tsuyoshi, Kawamoto, Tomohiro

“…Poly(ADP-ribose) polymerases (PARPs) use nicotinamide adenine dinucleotide (NAD+) as a co-substrate to transfer ADP-ribose when it releases nicotinamide as the…”
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Crystal Structure of a Human K‑Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d by Sogabe, Satoshi, Kamada, Yusuke, Miwa, Masanori, Niida, Ayumu, Sameshima, Tomoya, Kamaura, Masahiro, Yonemori, Kazuko, Sasaki, Shigekazu, Sakamoto, Jun-ichi, Sakamoto, Kotaro

“…The Ras proteins play roles in cell differentiation, proliferation, and survival. Aberrant signaling through Ras-mediated pathways in tumor cells occurs as a…”
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Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2 by Iwatani-Yoshihara, Misa, Ito, Masahiro, Klein, Michael G, Yamamoto, Takeshi, Yonemori, Kazuko, Tanaka, Toshio, Miwa, Masanori, Morishita, Daisuke, Endo, Satoshi, Tjhen, Richard, Qin, Ling, Nakanishi, Atsushi, Maezaki, Hironobu, Kawamoto, Tomohiro

“…Brr2 is an RNA helicase belonging to the Ski2-like subfamily and an essential component of spliceosome. Brr2 catalyzes an ATP-dependent unwinding of the U4/U6…”
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Identification of novel quinazolinedione derivatives as RORγt inverse agonist by Fukase, Yoshiyuki, Sato, Ayumu, Tomata, Yoshihide, Ochida, Atsuko, Kono, Mitsunori, Yonemori, Kazuko, Koga, Keiko, Okui, Toshitake, Yamasaki, Masashi, Fujitani, Yasushi, Nakagawa, Hideyuki, Koyama, Ryoukichi, Nakayama, Masaharu, Skene, Robert, Sang, Bi-Ching, Hoffman, Isaac, Shirai, Junya, Yamamoto, Satoshi

“…[Display omitted] Novel small molecules were synthesized and evaluated as retinoic acid receptor-related orphan receptor-gamma t (RORγt) inverse agonists for…”
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Design and synthesis of selective CDK8/19 dual inhibitors: Discovery of 4,5-dihydrothieno[3′,4′:3,4]benzo[1,2-d]isothiazole derivatives by Ono, Koji, Banno, Hiroshi, Okaniwa, Masanori, Hirayama, Takaharu, Iwamura, Naoki, Hikichi, Yukiko, Murai, Saomi, Hasegawa, Maki, Hasegawa, Yuka, Yonemori, Kazuko, Hata, Akito, Aoyama, Kazunobu, Cary, Douglas R.

“…[Display omitted] To develop a novel series of CDK8/19 dual inhibitors, we employed structure-based drug design using docking models based on a library…”
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Studies of CDK 8/19 inhibitors: Discovery of novel and selective CDK8/19 dual inhibitors and elimination of their CYP3A4 time-dependent inhibition potential by Fujimoto, Jun, Hirayama, Takaharu, Hirata, Yasuhiro, Hikichi, Yukiko, Murai, Saomi, Hasegawa, Maki, Hasegawa, Yuka, Yonemori, Kazuko, Hata, Akito, Aoyama, Kazunobu, Cary, Douglas R.

“…[Display omitted] In this article, synthetic studies around a pyridylacrylamide-based hit compound (1), utilizing structure-based drug design guided by CDK8…”
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Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents by Kojima, Takuto, Asano, Yasutomi, Kurasawa, Osamu, Hirata, Yasuhiro, Iwamura, Naoki, Wong, Tzu-Tshin, Saito, Bunnai, Tanaka, Yuta, Arai, Ryosuke, Yonemori, Kazuko, Miyamoto, Yasufumi, Sagiya, Yoji, Yaguchi, Masahiro, Shibata, Sachio, Mizutani, Akio, Sano, Osamu, Adachi, Ryutaro, Satomi, Yoshinori, Hirayama, Megumi, Aoyama, Kazunobu, Hiura, Yuto, Kiba, Atsushi, Kitamura, Shuji, Imamura, Shinichi

“…[Display omitted] We pursued serine palmitoyltransferase (SPT) inhibitors as novel cancer therapeutic agents based on a correlation between SPT inhibition and…”
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Discovery of orally efficacious RORγt inverse agonists, part 1: Identification of novel phenylglycinamides as lead scaffolds by Shirai, Junya, Tomata, Yoshihide, Kono, Mitsunori, Ochida, Atsuko, Fukase, Yoshiyuki, Sato, Ayumu, Masada, Shinichi, Kawamoto, Tetsuji, Yonemori, Kazuko, Koyama, Ryoukichi, Nakagawa, Hideyuki, Nakayama, Masaharu, Uga, Keiko, Shibata, Akira, Koga, Keiko, Okui, Toshitake, Shirasaki, Mikio, Skene, Robert, Sang, BiChing, Hoffman, Isaac, Lane, Wes, Fujitani, Yasushi, Yamasaki, Masashi, Yamamoto, Satoshi

“…[Display omitted] A series of novel phenylglycinamides as retinoic acid receptor-related orphan receptor-gamma t (RORγt) inverse agonists were discovered…”
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