Epidemic of dengue-4 virus in Yap State, Federated States of Micronesia, and implication of Aedes hensilli as an epidemic vector

A dengue fever/dengue hemorrhagic fever (DF/DHF) outbreak in Yap State caused by dengue-4 virus was confirmed serologically and by virus isolation from serum samples collected on each of three island groups. Most DF/DHF cases occurred during a three-month period between mid-May and early August 1995...

Full description

Saved in:

Bibliographic Details
Published in:	The American journal of tropical medicine and hygiene Vol. 58; no. 4; p. 519
Main Authors:	Savage, H M, Fritz, C L, Rutstein, D, Yolwa, A, Vorndam, V, Gubler, D J
Format:	Journal Article
Language:	English
Published:	United States 01-04-1998
Subjects:	Adolescent Adult Aedes - virology Animals Antibodies, Viral - blood Child Child, Preschool Culex - virology Dengue - epidemiology Dengue - transmission Dengue Virus - classification Dengue Virus - immunology Dengue Virus - isolation & purification Disease Outbreaks Enzyme-Linked Immunosorbent Assay Female Hemagglutination Inhibition Tests Housing Humans Immunoglobulins - blood Insect Vectors - virology Male Micronesia - epidemiology Rain Risk Factors Micronesia
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	A dengue fever/dengue hemorrhagic fever (DF/DHF) outbreak in Yap State caused by dengue-4 virus was confirmed serologically and by virus isolation from serum samples collected on each of three island groups. Most DF/DHF cases occurred during a three-month period between mid-May and early August 1995. Five fatal cases, three of which were in children between the ages of four and 11, occurred between June 20 and July 26. A serosurvey conducted in late August revealed anti-dengue IgM prevalence rates of 18% on Yap, 36% on Eauripik, and 6% on Woleai. The majority of residents (93-100%) on the three islands were positive for anti-dengue IgG antibodies, indicating widespread exposure to dengue viruses. The IgG titers indicative of secondary antibody response were noted on Eauripik (6.5%) and Woleai (17%), but were rare on Yap (0.7%). Entomologic investigations implicated the native mosquito species, Aedes hensilli, a member of the Scutellaris Group of Aedes (Stegomyia), as a previously unrecognized epidemic vector of dengue viruses. Aedes hensilli was the most abundant and widespread member of Ae. (Stegomyia) in Yap State, the only species of Ae. (Stegomyia) on Woleai, and the only mosquito species present on Eauripik. New distribution records for mosquito species are reported.
ISSN:	0002-9637
DOI:	10.4269/ajtmh.1998.58.519