Search Results - "Yokoyama, Masayuki "

Toxicity and immunogenicity concerns related to PEGylated-micelle carrier systems: a review by Shiraishi, Kouichi, Yokoyama, Masayuki

“…Polymeric-micelle carrier systems have emerged as a novel drug-carrier system and have been actively studied for anticancer drug targeting. In contrast,…”
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A polymeric micelle magnetic resonance imaging (MRI) contrast agent reveals blood–brain barrier (BBB) permeability for macromolecules in cerebral ischemia-reperfusion injury by Shiraishi, Kouichi, Wang, Zuojun, Kokuryo, Daisuke, Aoki, Ichio, Yokoyama, Masayuki

“…Blood–brain barrier (BBB) opening is a key phenomenon for understanding ischemia-reperfusion injuries that are directly linked to hemorrhagic transformation…”
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Stability evaluation of Gd chelates for macromolecular MRI contrast agents by Yokoyama, Masayuki, Shiraishi, Kouichi

“…Objective We try to establish designs for the macromolecular agents possessing high Gd 3+ -chelating stability, because free Gd 3+ ion released from Gd…”
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Partial Modification of Electron-withdrawing Groups in Thermally-activated Delayed Fluorescence Materials Aimed to Improve Efficiency and Stability by Yokoyama, Masayuki, Tsuchiya, Youichi, Nakanotani, Hajime, Adachi, Chihaya

“…Highly efficient and stable blue-green thermally-activated delayed fluorescence (TADF) molecules with trifluoromethyl (CF3) groups were developed. Partial…”
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Drug targeting with nano-sized carrier systems by Yokoyama, Masayuki

“…This paper discusses the present status of, and future perspectives on, drug targeting through the bloodstream by describing the drug targeting concept, its…”
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Hydrophobic blocks of PEG-conjugates play a significant role in the accelerated blood clearance (ABC) phenomenon by Shiraishi, Kouichi, Hamano, Mikiko, Ma, Huili, Kawano, Kumi, Maitani, Yoshie, Aoshi, Taiki, Ishii, Ken J., Yokoyama, Masayuki

“…Injections of poly(ethylene glycol)-modified liposomes (PEG-liposomes) cause rapid clearance of the second dose of PEG-liposomes. This phenomenon is known as…”
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Preparation and Commissioning for the LHD Deuterium Experiment by Osakabe, Masaki, Isobe, Mitsutaka, Tanaka, Masahiro, Motojima, Gen, Tsumori, Katsuyoshi, Yokoyama, Masayuki, Morisaki, Tomohiro, Takeiri, Yasuhiko

“…The deuterium experiment started from March 2017 on the large helical device (LHD) as a part of the LHD high-performance upgrade project. The objectives of the…”
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Extending the total neutron emission rate of steady-state deuterium large helical plasma guided by a data-driven approach by Ogawa, Kunihiro, Isobe, Mitsutaka, Yokoyama, Masayuki

“…•A trial for extending the total neutron emission rate was performed in steady state deuterium large helical plasma.•A quantitative guidance is acquired by…”
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Impact of the Hydrophilicity of Poly(sarcosine) on Poly(ethylene glycol) (PEG) for the Suppression of Anti-PEG Antibody Binding by Maiti, Debabrata, Yokoyama, Masayuki, Shiraishi, Kouichi

“…A method of poly­(ethylene glycol) (PEG) conjugation is known as PEGylation, which has been employed to deliver therapeutic drugs, proteins, or nanoparticles…”
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Preparation and in vivo imaging of PEG-poly(L-lysine)-based polymeric micelle MRI contrast agents by Shiraishi, Kouichi, Kawano, Kumi, Minowa, Takuya, Maitani, Yoshie, Yokoyama, Masayuki

“…A polymeric micelle drug carrier system was applied to the targeting of an MRI (magnetic resonance imaging) contrast agent. A block copolymer, PEG-…”
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Determination of polymeric micelles' structural characteristics, and effect of the characteristics on pharmacokinetic behaviors by Shiraishi, Kouichi, Sanada, Yusuke, Mochizuki, Shinichi, Kawano, Kumi, Maitani, Yoshie, Sakurai, Kazuo, Yokoyama, Masayuki

“…We evaluated structural factors characterizing PEG-b-P(Asp-Bzl) micelles including core size, aggregation number (Nagg), and core surface PEG density by means…”
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Exploring the relationship between anti-PEG IgM behaviors and PEGylated nanoparticles and its significance for accelerated blood clearance by Shiraishi, Kouichi, Kawano, Kumi, Maitani, Yoshie, Aoshi, Taiki, Ishii, Ken J., Sanada, Yusuke, Mochizuki, Shinichi, Sakurai, Kazuo, Yokoyama, Masayuki

“…Surface PEGylation on nanoparticles has greatly helped prolong their blood circulation half-lives. However, The injection of PEGylated nanoparticles into mice…”
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Single intratracheal administration of cross-linked water-soluble acrylic acid polymer causes acute alveolo-interstitial inflammation and the subsequent fibrotic formation possibly via the TGF-β1 pathway in the lung of rats by Suka, Machi, Kido, Takamasa, Yoshioka, Wataru, Hachisuka, Eri, Okoshi, Hiroto, Yamauchi, Takashi, Hano, Hiroshi, Okano, Takashi, Yokoyama, Masayuki, Yanagisawa, Hiroyuki

“…•Cross-linked water-soluble acrylic acid polymer can cause lung inflammation.•Its thickening effect disturbs lung clearance and thus prolongs…”
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Sequential therapy with sorafenib and regorafenib for advanced hepatocellular carcinoma: a multicenter retrospective study in Japan by Ogasawara, Sadahisa, Ooka, Yoshihiko, Itokawa, Norio, Inoue, Masanori, Okabe, Shinichiro, Seki, Atsuyoshi, Haga, Yuki, Obu, Masamichi, Atsukawa, Masanori, Itobayashi, Ei, Mizumoto, Hideaki, Sugiura, Nobuyuki, Azemoto, Ryosaku, Kanayama, Kengo, Kanzaki, Hiroaki, Maruta, Susumu, Maeda, Takahiro, Kusakabe, Yuko, Yokoyama, Masayuki, Kobayashi, Kazufumi, Kiyono, Soichiro, Nakamura, Masato, Saito, Tomoko, Suzuki, Eiichiro, Nakamoto, Shingo, Yasui, Shin, Tawada, Akinobu, Chiba, Tetsuhiro, Arai, Makoto, Kanda, Tatsuo, Maruyama, Hitoshi, Kato, Naoya

“…Summary Background Conversion from sorafenib to regorafenib is primarily an evidence-based treatment strategy in patients with advanced hepatocellular…”
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Efficacy and safety of upadacitinib over 84 weeks in Japanese patients with rheumatoid arthritis (SELECT-SUNRISE) by Kameda, Hideto, Takeuchi, Tsutomu, Yamaoka, Kunihiro, Oribe, Motohiro, Kawano, Mitsuhiro, Yokoyama, Masayuki, Pangan, Aileen L, Konishi, Yuko, Meerwein, Sebastian, Tanaka, Yoshiya

“…The objective of the study was to evaluate the efficacy and safety of upadacitinib over 84 weeks in Japanese patients with active rheumatoid arthritis (RA) and…”
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First application of data assimilation-based control to fusion plasma by Morishita, Yuya, Murakami, Sadayoshi, Kenmochi, Naoki, Funaba, Hisamichi, Yamada, Ichihiro, Mizuno, Yoshinori, Nagahara, Kazuki, Nuga, Hideo, Seki, Ryosuke, Yokoyama, Masayuki, Ueno, Genta, Osakabe, Masaki

“…Magnetic fusion plasmas, which are complex systems comprising numerous interacting elements, have large uncertainties. Therefore, future fusion reactors…”
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Polymeric Micelles Possessing Polyethyleneglycol as Outer Shell and Their Unique Behaviors in Accelerated Blood Clearance Phenomenon by Shiraishi, Kouichi, Yokoyama, Masayuki

“…Polymeric micelles are assemblies of synthetic polymers and have been studied and developed as drug carriers for targeting. Polymeric micelles are composed of…”
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PEG‐poly(L‐lysine)‐based polymeric micelle MRI contrast agent: Feasibility study of a Gd‐micelle contrast agent for MR lymphography by Akai, Hiroyuki, Shiraishi, Kouichi, Yokoyama, Masayuki, Yasaka, Koichiro, Nojima, Masanori, Inoue, Yusuke, Abe, Osamu, Ohtomo, Kuni, Kiryu, Shigeru

“…Purpose To investigate the feasibility of polymeric micelle of poly(ethyleneglycol) (PEG)‐b‐poly(L‐lysine‐DOTA) (Gd‐micelle) as a contrast agent for magnetic…”
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Size-dependent induction of accelerated blood clearance phenomenon by repeated injections of polymeric micelles by Koide, Hiroyuki, Asai, Tomohiro, Kato, Hiroki, Ando, Hidenori, Shiraishi, Kouichi, Yokoyama, Masayuki, Oku, Naoto

“…An accelerated blood clearance (ABC) phenomenon is induced by repeated injections of poly(ethylene glycol)-modified (PEGylated) liposomes. We previously…”
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Diagnostic value of peroral cholangioscopy in addition to computed tomography for indeterminate biliary strictures by Shima, Yukiko, Sugiyama, Harutoshi, Ogasawara, Sadahisa, Kan, Motoyasu, Maruta, Shikiko, Yamada, Toshihito, Miura, Yoshifumi, Asano, Kosho, Sensui, Miyuki, Nagashima, Hiroki, Yokoyama, Masayuki, Kusakabe, Yuko, Yasui, Shin, Ohno, Izumi, Mikata, Rintaro, Tsuyuguchi, Toshio, Horikoshi, Takuro, Mishima, Takashi, Kuboki, Satoshi, Takayashiki, Tsukasa, Ohtsuka, Masayuki, Kato, Jun, Kato, Naoya

“…Background Peroral cholangioscopy (POCS) has been used to overcome the difficulty in diagnosing indeterminate biliary stricture or tumor spread. However, the…”
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