Search Results - "Yokouchi, Mariko"

Epidermal cell turnover across tight junctions based on Kelvin's tetrakaidecahedron cell shape by Yokouchi, Mariko, Atsugi, Toru, Logtestijn, Mark van, Tanaka, Reiko J, Kajimura, Mayumi, Suematsu, Makoto, Furuse, Mikio, Amagai, Masayuki, Kubo, Akiharu

“…In multicellular organisms, cells adopt various shapes, from flattened sheets of endothelium to dendritic neurons, that allow the cells to function…”
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Functional tight junction barrier localizes in the second layer of the stratum granulosum of human epidermis by Yoshida, Kazue, Yokouchi, Mariko, Nagao, Keisuke, Ishii, Ken, Amagai, Masayuki, Kubo, Akiharu

“…Abstract Background Mammalian epidermis has two diffusion barriers, the stratum corneum (SC) and tight junctions (TJs). We reported previously that a single…”
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Epidermal tight junction barrier function is altered by skin inflammation, but not by filaggrin-deficient stratum corneum by Yokouchi, Mariko, Kubo, Akiharu, Kawasaki, Hiroshi, Yoshida, Kazue, Ishii, Ken, Furuse, Mikio, Amagai, Masayuki

“…Abstract Background The tight junction (TJ) barrier is located in the granular layer of the epidermis. Filaggrin deficiency predisposes patients to atopic…”
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Distinct behavior of human Langerhans cells and inflammatory dendritic epidermal cells at tight junctions in patients with atopic dermatitis by Yoshida, Kazue, MD, PhD, Kubo, Akiharu, MD, PhD, Fujita, Harumi, PhD, Yokouchi, Mariko, MD, Ishii, Ken, MD, PhD, Kawasaki, Hiroshi, MD, PhD, Nomura, Toshifumi, MD, PhD, Shimizu, Hiroshi, MD, PhD, Kouyama, Keisuke, MD, PhD, Ebihara, Tamotsu, MD, PhD, Nagao, Keisuke, MD, PhD, Amagai, Masayuki, MD, PhD

“…Background The stratum corneum and tight junctions (TJs) form physical barriers in the epidermis. Dendrites of activated Langerhans cells (LCs) extend beyond…”
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Holocrine Secretion Occurs outside the Tight Junction Barrier in Multicellular Glands: Lessons from Claudin-1–Deficient Mice by Atsugi, Toru, Yokouchi, Mariko, Hirano, Takashige, Hirabayashi, Ai, Nagai, Toshihiro, Ohyama, Manabu, Abe, Takaya, Kaneko, Mari, Zouboulis, Christos C., Amagai, Masayuki, Kubo, Akiharu

“…Holocrine secretion is a specific mode of secretion involving secretion of entire cytoplasmic materials with remnants of dead cells, as observed in…”
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Langerhans cell antigen capture through tight junctions confers preemptive immunity in experimental staphylococcal scalded skin syndrome by Ouchi, Takeshi, Kubo, Akiharu, Yokouchi, Mariko, Adachi, Takeya, Kobayashi, Tetsuro, Kitashima, Daniela Y, Fujii, Hideki, Clausen, Björn E, Koyasu, Shigeo, Amagai, Masayuki, Nagao, Keisuke

“…Epidermal Langerhans cells (LCs) extend dendrites through tight junctions (TJs) to survey the skin surface, but their immunological contribution in vivo…”
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Non-pathogenic pemphigus foliaceus (PF) IgG acts synergistically with a directly pathogenic PF IgG to increase blistering by p38MAPK-dependent desmoglein 1 clustering by Yoshida, Kenji, Ishii, Ken, Shimizu, Atsushi, Yokouchi, Mariko, Amagai, Masayuki, Shiraishi, Ken, Shirakata, Yuji, Stanley, John R, Ishiko, Akira

“…Highlights • PF sera contain both pathogenic and non-pathogenic anti-Dsg1 IgG. • A mixture of PF mAbs disrupted cell adhesion more than a single pathogenic…”
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Case of dipeptidyl peptidase 4 inhibitor‐associated bullous pemphigoid that developed after a scabies infestation by Iriki, Hisato, Adachi, Takahiro, Matsuda, Hideshi, Chinen, Katsuya, Arakawa, Hiroki, Yamagami, Jun, Nishie, Wataru, Yokouchi, Mariko

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Pathogenic Epitopes of Autoantibodies in Pemphigus Reside in the Amino-Terminal Adhesive Region of Desmogleins Which Are Unmasked by Proteolytic Processing of Prosequence by Yokouchi, Mariko, Saleh, Marwah Adly, Kuroda, Keiko, Hachiya, Takahisa, Stanley, John R., Amagai, Masayuki, Ishii, Ken

“…Pemphigus targets desmogleins (Dsgs), which are thought to be synthesized as inactive precursor proteins with prosequences that are cleaved by substilisin-like…”
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Maintenance of tight junction barrier integrity in cell turnover and skin diseases by Yokouchi, Mariko, Kubo, Akiharu

“…The skin forms a life‐sustaining barrier between the organism and the physical environment. The physical barrier of the skin is mainly comprised of the stratum…”
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External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers by Kubo, Akiharu, Nagao, Keisuke, Yokouchi, Mariko, Sasaki, Hiroyuki, Amagai, Masayuki

“…Outermost barriers are critical for terrestrial animals to avoid desiccation and to protect their bodies from foreign insults. Mammalian skin consists of two…”
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Epidermis-specific ablation of claudin-1 in adult mice demonstrates the essential role of a tight junction barrier in skin homeostasis by Hirano, Takashige, Yokouchi, Mariko, Atsugi, Toru, Amagai, Masayuki, Kubo, Akiharu

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Functional tight junction barriers in sebaceous glands: Defects in holocrine secretion in claudin-1 deficient mice by Atsugi, Toru, Yokouchi, Mariko, Hirabayashi, Ai, Ohyama, Manabu, Amagai, Masayuki, Kubo, Akiharu

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Homeostatic cell turnover mechanisms that maintain tight junction barrier integrity in the epidermis by Yokouchi, Mariko, Kajimura, Mayumi, Suematsu, Makoto, Furuse, Mikio, Amagai, Masayuki, Kubo, Akiharu

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p38MAPK contributes to loss of cell adhesion through clustering of desmoglein 1 but is not required for blistering in pemphigus foliaceus by Yoshida, Kenji, Ishii, Ken, Shimizu, Atsushi, Yokouchi, Mariko, Amagai, Masayuki, Stanley, John R, Ishiko, Akira

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A combination of pemphigus foliaceus IgG monoclonal antibodies promotes desmoglein 1 clustering which induces synergistic pathogenic effect by Yoshida, Kenji, Ishii, Ken, Shimizu, Atsushi, Yokouchi, Mariko, Amagai, Masayuki, Stanley, John R, Ishiko, Akira

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External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers by Kubo, Akiharu, Nagao, Keisuke, Yokouchi, Mariko, Sasaki, Hiroyuki, Amagai, Masayuki

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Case of dipeptidyl peptidase 4 inhibitor-associated bullous pemphigoid that developed after a scabies infestation by Iriki, Hisato, Adachi, Takahiro, Matsuda, Hideshi, Chinen, Katsuya, Arakawa, Hiroki, Yamagami, Jun, Nishie, Wataru, Yokouchi, Mariko

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