Search Results - "Yokota, Takanori"

Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood–brain barrier and knock down genes in the rodent CNS by Nagata, Tetsuya, Dwyer, Chrissa A., Yoshida-Tanaka, Kie, Ihara, Kensuke, Ohyagi, Masaki, Kaburagi, Hidetoshi, Miyata, Haruka, Ebihara, Satoe, Yoshioka, Kotaro, Ishii, Takashi, Miyata, Kanjiro, Miyata, Kenichi, Powers, Berit, Igari, Tomoko, Yamamoto, Syunsuke, Arimura, Naoto, Hirabayashi, Hideki, Uchihara, Toshiki, Hara, Rintaro Iwata, Wada, Takeshi, Bennett, C. Frank, Seth, Punit P., Rigo, Frank, Yokota, Takanori

“…Achieving regulation of endogenous gene expression in the central nervous system (CNS) with antisense oligonucleotides (ASOs) administered systemically would…”
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Peripheral Nerve and Muscle Disorders Associated with Sjögren's Syndrome by Kuwahara, Hiroya, Yokota, Takanori

“…Sjögren's syndrome is often accompanied by various neurological complications, among which peripheral neuropathy is the most common. A variety of clinical…”
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Tandem internal models execute motor learning in the cerebellum by Honda, Takeru, Nagao, Soichi, Hashimoto, Yuji, Ishikawa, Kinya, Yokota, Takanori, Mizusawa, Hidehiro, Ito, Masao

“…In performing skillful movement, humans use predictions from internal models formed by repetition learning. However, the computational organization of internal…”
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DNA/RNA heteroduplex oligonucleotide technology for regulating lymphocytes in vivo by Ohyagi, Masaki, Nagata, Tetsuya, Ihara, Kensuke, Yoshida-Tanaka, Kie, Nishi, Rieko, Miyata, Haruka, Abe, Aya, Mabuchi, Yo, Akazawa, Chihiro, Yokota, Takanori

“…Manipulating lymphocyte functions with gene silencing approaches is promising for treating autoimmunity, inflammation, and cancer. Although oligonucleotide…”
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Cerebral venous sinus thrombosis after mRNA-based COVID-19 vaccination by Yagi, Yohsuke, Asami, Yutaro, Kyoya, Mitsuki, Yokota, Takanori

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Parallel gold enhancement of quantum dots 565/655 for double-labelling correlative light and electron microscopy on human autopsied samples by Uematsu, Miho, Mikami, Kyohei, Nakamura, Ayako, Takahashi, Ryosuke, Yokota, Takanori, Hirokawa, Katsuiku, Uchihara, Toshiki

“…Cadmium selenide quantum dots (QDs) are fluorescent and electron-dense nanoparticles. When used as reporter of immunolabeling, this dual visibility is…”
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Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson’s disease by Uehara, Takuya, Choong, Chi-Jing, Nakamori, Masayuki, Hayakawa, Hideki, Nishiyama, Kumiko, Kasahara, Yuuya, Baba, Kousuke, Nagata, Tetsuya, Yokota, Takanori, Tsuda, Hiroshi, Obika, Satoshi, Mochizuki, Hideki

“…Parkinson’s disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra. A characteristic pathological…”
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ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1 by Nishitoh, Hideki, Kadowaki, Hisae, Nagai, Atsushi, Maruyama, Takeshi, Yokota, Takanori, Fukutomi, Hisashi, Noguchi, Takuya, Matsuzawa, Atsushi, Takeda, Kohsuke, Ichijo, Hidenori

“…Mutation in Cu/Zn-superoxide dismutase (SOD1) is a cause of familial amyotrophic lateral sclerosis (ALS). Mutant SOD1 protein (SOD1(mut)) induces motor neuron…”
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Next-generation sequencing-based small RNA profiling of cerebrospinal fluid exosomes by Yagi, Yohsuke, Ohkubo, Takuya, Kawaji, Hideya, Machida, Akira, Miyata, Haruka, Goda, Saori, Roy, Sugata, Hayashizaki, Yoshihide, Suzuki, Harukazu, Yokota, Takanori

“…•This study used NGS to analyse CSF and serum exosomal fractions.•Exosomal miRNA profiles differed between CSF and serum.•miR-1911-5p was specific for CSF…”
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Regulation of activated microglia and macrophages by systemically administered DNA/RNA heteroduplex oligonucleotides by Nishi, Rieko, Ohyagi, Masaki, Nagata, Tetsuya, Mabuchi, Yo, Yokota, Takanori

“…Microglial activation followed by recruitment of blood-borne macrophages into the central nervous system (CNS) aggravates neuroinflammation. Specifically, in…”
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Diabetic Polyneuropathy: New Strategies to Target Sensory Neurons in Dorsal Root Ganglia by Miyashita, Akiko, Kobayashi, Masaki, Yokota, Takanori, Zochodne, Douglas W

“…Diabetic polyneuropathy (DPN) is the most common type of diabetic neuropathy, rendering a slowly progressive, symmetrical, and length-dependent dying-back…”
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Serial changes in regional cerebral blood flow in Gerstmann–Sträussler–Scheinker disease caused by a Pro-to-Leu mutation at codon 105 in the prion protein gene by Kawai, Honami, Matsubayashi, Taiki, Yokota, Takanori, Sanjo, Nobuo

“…Gerstmann-Sträussler-Scheinker disease with a Pro-to-Leu substitution at codon 105 in the prion protein gene (GSS-P105L) is a rare variant of human genetic…”
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Evaluation of the risk factors predicting thrombotic complications associated with intravenous immunoglobulin therapy in neuroimmunological diseases by Noda, Kotaro, Yagi, Yohsuke, Yokota, Takanori

“…Intravenous immunoglobulin (IVIg) therapy is increasingly used for various conditions that include neuroimmunological disorders, such as chronic inflammatory…”
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Amyloid-β oligomers interact with NMDA receptors containing GluN2B subunits and metabotropic glutamate receptor 1 in primary cortical neurons: Relevance to the synapse pathology of Alzheimer’s disease by Taniguchi, Kaori, Yamamoto, Fumiko, Amano, Akiko, Tamaoka, Akira, Sanjo, Nobuo, Yokota, Takanori, Kametani, Fuyuki, Araki, Wataru

“…Recent evidence suggests that soluble amyloid-β oligomers (AβOs) act as a key factor in the pathogenetic mechanism of Alzheimer's disease (AD). AβOs induce…”
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Striatal Dopamine Denervation Impairs Gait Automaticity in Drug‐Naïve Parkinson's Disease Patients by Hirata, Kosei, Hattori, Takaaki, Kina, Satoko, Chen, Qingmeng, Ohara, Masahiro, Yokota, Takanori

“…Background Gait automaticity, which is impaired in patients with Parkinson's disease (PD), can be quantified by gait variability analysis. Among the 3 regions…”
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Cryptogenic New-onset Refractory Status Epilepticus with Hyperintensity of T1-weighted Magnetic Resonance Imaging in the Bilateral Basal Ganglia: An Autopsy Report by Takahashi, Sunao, Ono, Daisuke, Shintaku, Hiroshi, Oyama, Jun, Nishida, Yoichiro, Ishikawa, Kinya, Yokota, Takanori

“…We present a 76-year-old man with cryptogenic new-onset refractory status epilepticus (C-NORSE) with an initial abnormal signal in the nucleus accumbens and a…”
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Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31 by Ishiguro, Taro, Sato, Nozomu, Ueyama, Morio, Fujikake, Nobuhiro, Sellier, Chantal, Kanegami, Akemi, Tokuda, Eiichi, Zamiri, Bita, Gall-Duncan, Terence, Mirceta, Mila, Furukawa, Yoshiaki, Yokota, Takanori, Wada, Keiji, Taylor, J. Paul, Pearson, Christopher E., Charlet-Berguerand, Nicolas, Mizusawa, Hidehiro, Nagai, Yoshitaka, Ishikawa, Kinya

“…Microsatellite expansion disorders are pathologically characterized by RNA foci formation and repeat-associated non-AUG (RAN) translation. However, their…”
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Effective silencing of miR-126 after ischemic stroke by means of intravenous α-tocopherol–conjugated heteroduplex oligonucleotide in mice by Suzuki, Motohiro, Ishibashi, Satoru, Iwasawa, Eri, Oguma, Takahiro, Saito, Yasuhiro, Li, Fuying, Otsu, Shinichi, Ichinose, Keiko, Yoshioka, Kotaro, Nagata, Tetsuya, Yokota, Takanori

“…Brain endothelial cells (BECs) are involved in the pathogenesis of ischemic stroke. Recently, several microRNAs (miRNAs) in BECs were reported to regulate the…”
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Turning and multitask gait unmask gait disturbance in mild‐to‐moderate multiple sclerosis: Underlying specific cortical thinning and connecting fibers damage by Chen, Qingmeng, Hattori, Takaaki, Tomisato, Hiroshi, Ohara, Masahiro, Hirata, Kosei, Yokota, Takanori

“…Multiple sclerosis (MS) causes gait and cognitive impairments that are partially normalized by compensatory mechanisms. We aimed to identify the gait tasks…”
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Quantitative clinical and radiological recovery in post-operative patients with superficial siderosis by an iron chelator by Nose, Yurie, Uwano, Ikuko, Tateishi, Ukihide, Sasaki, Makoto, Yokota, Takanori, Sanjo, Nobuo

“…Background Superficial siderosis is a rare neurodegenerative disease caused by hemosiderin deposition on the brain surface. Although the efficacy of the iron…”
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