Search Results - "Yokota, Takaaki"

Efficacy of Naldemedine on Intestinal Hypomotility and Adhesions in Rodent Models of Postoperative Ileus by Azuma, Yuki, Koike, Katsumi, Chiba, Hiroki, Mitamura, Aki, Tsuji, Hiroki, Kawasaki, Sachiko, Yokota, Takaaki, Kanemasa, Toshiyuki, Morioka, Yasuhide, Suzuki, Tsutomu, Fujita, Masahide

“…Postoperative ileus (POI) often decreases patients’ QOL because of prolonged hospitalization and readmission. Alvimopan, a peripheral μ-opioid receptor…”
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Naldemedine in Japanese patients with opioid-induced constipation and chronic noncancer pain: open-label Phase III studies by Saito, Yoji, Yokota, Takaaki, Arai, Masatsugu, Tada, Yukio, Sumitani, Masahiko

“…Naldemedine is a peripherally-acting µ-opioid-receptor antagonist, approved in Japan for opioid-induced constipation (OIC). In two open-label, single-arm,…”
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Naldemedine is effective in the treatment of opioid-induced constipation in patients with chronic non-cancer pain who had a poor response to laxatives by Hale, Martin E., Wild, James E., Yamada, Tadaaki, Yokota, Takaaki, Tack, Jan, Andresen, Viola, Drewes, Asbjørn Mohr

“…Background: Two studies demonstrated the efficacy and safety of naldemedine in adult patients with chronic non-cancer pain and opioid-induced constipation…”
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Phase 1, Randomized, Double‐Blind, Placebo‐Controlled Studies on the Safety, Tolerability, and Pharmacokinetics of Naldemedine in Healthy Volunteers by Fukumura, Kazuya, Yokota, Takaaki, Baba, Yuko, Arjona Ferreira, Juan Camilo

“…Naldemedine (S‐297995) is a peripherally acting μ‐opioid receptor antagonist for the treatment of opioid‐induced constipation, a common side effect of opioid…”
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Safety and efficacy of naldemedine in cancer patients with opioid-induced constipation: a pooled, subgroup analysis of two randomised controlled studies by Osaka, Iwao, Ishiki, Hiroto, Yokota, Takaaki, Tada, Yukio, Sato, Hiroki, Okamoto, Masaharu, Satomi, Eriko

“…ObjectiveThis post hoc, pooled, subgroup analysis of two randomised studies evaluated baseline characteristics that may influence the efficacy and safety of…”
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Enantioselective aldol reactions of trichlorosilyl enol ethers catalyzed by chiral N, N′-dioxides and monodentate N-oxides by Nakajima, Makoto, Yokota, Takaaki, Saito, Makoto, Hashimoto, Shunichi

“…Graphic Chiral N, N ′-dioxides and monodentate N-oxides were employed as catalysts in catalytic, enantioselective aldol reactions of trichlorosilyl enol…”
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Randomized Phase III and Extension Studies of Naldemedine in Patients With Opioid-Induced Constipation and Cancer by Katakami, Nobuyuki, Harada, Toshiyuki, Murata, Toru, Shinozaki, Katsunori, Tsutsumi, Masakazu, Yokota, Takaaki, Arai, Masatsugu, Tada, Yukio, Narabayashi, Masaru, Boku, Narikazu

“…Purpose Opioid-induced constipation (OIC) is a frequent and debilitating adverse effect (AE) of opioids-common analgesics for cancer pain. We investigated the…”
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Reply to Y. Yagi et al by Katakami, Nobuyuki, Yokota, Takaaki, Tada, Yukio

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Effect of add-on naldemedine treatment in patients with cancer and opioid-induced constipation insufficiently responding to magnesium oxide: a pooled, subgroup analysis of two randomized controlled trials by Kessoku, Takaomi, Akamatsu, Toshikazu, Morioka, Yasuhide, Yokota, Takaaki, Kobayashi, Masayuki, Uchida, Kohei, Koretaka, Yuichi, Nakajima, Atsushi

“…To evaluate the additive effect of naldemedine tosylate (naldemedine) on opioid-induced constipation in cancer patients insufficiently responding to magnesium…”
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Phase IIb, Randomized, Double-Blind, Placebo-Controlled Study of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients With Cancer by Katakami, Nobuyuki, Oda, Koji, Tauchi, Katsunori, Nakata, Ken, Shinozaki, Katsunori, Yokota, Takaaki, Suzuki, Yura, Narabayashi, Masaru, Boku, Narikazu

“…Purpose This randomized, double-blind, multicenter study aimed to determine the dose of naldemedine, a peripherally-acting μ-opioid receptor antagonist, for…”
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Efficacy of Naldemedine on Intestinal Hypomotility and Adhesions in Rodent Models of Postoperative Ileus by Azuma, Yuki, Koike, Katsumi, Chiba, Hiroki, Mitamura, Aki, Tsuji, Hiroki, Kawasaki, Sachiko, Yokota, Takaaki, Kanemasa, Toshiyuki, Morioka, Yasuhide, Suzuki, Tsutomu, Fujita, Masahide

“…Postoperative ileus (POI) often decreases patients’ quality of life because of prolonged hospitalization and readmission. Alvimopan, a peripheral μ-opioid…”
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Su1596 Phase 1, Randomized, Double-Blind, Placebo-Controlled Studies of the Safety, Tolerability and Pharmacokinetics of Naldemedine in Healthy Volunteers by Fukumura, Kazuya, Yokota, Takaaki, Baba, Yuko, Ferreira, Juan Camilo Arjona

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The Influence of Renal or Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Naldemedine by Fukumura, Kazuya, Yamada, Tadaaki, Yokota, Takaaki, Kawasaki, Akira

“…Naldemedine is a peripherally acting μ‐opioid‐receptor antagonist for the treatment of opioid‐induced constipation. Two phase 1 single‐dose studies…”
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Naldemedine Is Effective in the Treatment of Opioid-Induced Constipation in Chronic Non-Cancer Pain in Subjects With or Without Inadequate Response to Laxatives: 431 by Tack, Jan, Hale, Martin E., Krauter, Eric, Yamada, Tadaaki, Yokota, Takaaki, Wild, James E.

“…Introduction: Opioid-induced constipation (OIC), a common side effect of opioid utilization in treating chronic non-cancer pain, is caused by the action of…”
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Safety and Efficacy of Naldemedine in Treatment of Opioid-Induced Constipation in Chronic Noncancer Subjects Determined to Be Laxative Inadequate Responders: An Exploratory Analysis from Two Phase III, Randomized, Double-Blind, Placebo-Controlled Clinical Studies by Krauter, Eric, Hale, Ma, Wild, James E, Yamada, Tadaaki, Yokota, Takaaki, Tack, Jan

“…Introduction: Opioids effectively treat pain yet may be limited by side effects, including constipation. Naldemedine is an oral, peripherally acting…”
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Phase 3 study to evaluate the efficacy and safety of naldemedine for the treatment of opioid-induced constipation (OIC) in cancer patients by Harada, Toshiyuki, Katakami, Nobuyuki, Murata, Toru, Shinozaki, Katsunori, Tsutsumi, Masakazu, Yokota, Takaaki, Arai, Masatsugu, Suzuki, Yura, Narabayashi, Masaru, Boku, Narikazu

“…Abstract only…”
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A phase II randomized, double-blind, placebo-controlled study to evaluate naldemedine for the treatment of opioid-induced constipation (OIC) in patients with cancer pain by Boku, Narikazu, Katakami, Nobuyuki, Fujita, Shiro, Oda, Koji, Tauchi, Katsunori, Nakata, Ken, Shinozaki, Katsunori, Okuno, Motoyasu, Kawai, Yasukazu, Kikukawa, Hiroaki, Suzuki, Ryujiro, Nakazawa, Hideo, Kojima, Hiroshi, Mizutani, Mitsuhiro, Hara, Toru, Yokota, Takaaki, Suzuki, Yura, Narabayashi, Masaru

“…Abstract only…”
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