Search Results - "Yokota, Naoto"

Febuxostat for Cerebral and CaRdiorenovascular Events PrEvEntion StuDy by Kojima, Sunao, Matsui, Kunihiko, Hiramitsu, Shinya, Hisatome, Ichiro, Waki, Masako, Uchiyama, Kazuaki, Yokota, Naoto, Tokutake, Eiichi, Wakasa, Yutaka, Jinnouchi, Hideaki, Kakuda, Hirokazu, Hayashi, Takahiro, Kawai, Naoki, Mori, Hisao, Sugawara, Masahiro, Ohya, Yusuke, Kimura, Kazuo, Saito, Yoshihiko, Ogawa, Hisao

“…Abstract Aims To compare the occurrence of cerebral, cardiovascular, and renal events in patients with hyperuricaemia treated with febuxostat and those treated…”
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Nuclear accumulation of ZFP36L1 is cell cycle-dependent and determined by a C-terminal serine-rich cluster by Matsuura, Yuki, Noguchi, Aya, Sakai, Shunsuke, Yokota, Naoto, Kawahara, Hiroyuki

“…Abstract ZFP36L1 is an RNA-binding protein responsible for mRNA decay in the cytoplasm. ZFP36L1 has also been suggested as a nuclear-cytoplasmic shuttling…”
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BAG6 contributes to glucose uptake by supporting the cell surface translocation of the glucose transporter GLUT4 by Minami, Setsuya, Yokota, Naoto, Kawahara, Hiroyuki

“…Defective translocation of glucose transporter 4 (GLUT4) to the cell surface is a key feature of insulin resistance in type 2 diabetes. Therefore, elucidating…”
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BAG6 deficiency induces mis‐distribution of mitochondrial clusters under depolarization by Hayashishita, Mizuki, Kawahara, Hiroyuki, Yokota, Naoto

“…Accumulation of damaged mitochondria is implicated in a number of neurodegenerative disorders, including Parkinson's disease. Therefore, the machinery for…”
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Sperm proteasomes are responsible for the acrosome reaction and sperm penetration of the vitelline envelope during fertilization of the sea urchin Pseudocentrotus depressus by Yokota, Naoto, Sawada, Hitoshi

“…The roles of sperm proteasomes in fertilization were investigated in the sea urchin Pseudocentrotus depressus. Two proteasome inhibitors, MG-132 and MG-115,…”
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Febuxostat and renal outcomes: post-hoc analysis of a randomized trial by Kohagura, Kentaro, Kojima, Sunao, Uchiyama, Kazuaki, Yokota, Naoto, Tokutake, Eiichi, Wakasa, Yutaka, Hiramitsu, Shinya, Waki, Masako, Jinnouchi, Hideaki, Kakuda, Hirokazu, Hayashi, Takahiro, Kawai, Naoki, Sugawara, Masahiro, Mori, Hisao, Tsujita, Kenichi, Matsui, Kunihiko, Hisatome, Ichiro, Ohya, Yusuke, Kimura, Kazuo, Saito, Yoshihiko, Ogawa, Hisao

“…Effect of urate-lowering on renal outcomes in patients at high-risk for cardiovascular disease with hyperuricemia without gout is not known. We conducted a…”
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ZFP36L2 is a cell cycle-regulated CCCH protein necessary for DNA lesion-induced S-phase arrest by Noguchi, Aya, Adachi, Shungo, Yokota, Naoto, Hatta, Tomohisa, Natsume, Tohru, Kawahara, Hiroyuki

“…ZFP36L2 promotes the destruction of AU-rich element-containing transcripts, while its regulation and functional significance in cell cycle control are scarcely…”
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conserved island of BAG6/Scythe is related to ubiquitin domains and participates in short hydrophobicity recognition by Tanaka, Hirofumi, Takahashi, Toshiki, Xie, Yiming, Minami, Ryosuke, Yanagi, Yuko, Hayashishita, Mizuki, Suzuki, Rigel, Yokota, Naoto, Shimada, Masumi, Mizushima, Tsunehiro, Kuwabara, Naoyuki, Kato, Ryuichi, Kawahara, Hiroyuki

“…BAG6 (also called Scythe) interacts with the exposed hydrophobic regions of newly synthesized proteins and escorts them to the degradation machinery through…”
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Evidence for participation of GCS1 in fertilization of the starlet sea anemone Nematostella vectensis: Implication of a common mechanism of sperm–egg fusion in plants and animals by Ebchuqin, Eerdundagula, Yokota, Naoto, Yamada, Lixy, Yasuoka, Yuuri, Akasaka, Mari, Arakawa, Mio, Deguchi, Ryusaku, Mori, Toshiyuki, Sawada, Hitoshi

“…•GCS1 is a sperm transmembrane protein that is essential for gamete fusion in flowering plants.•The GCS1 gene is present not only in angiosperms but also in…”
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Rationale, design, and baseline characteristics of a study to evaluate the effect of febuxostat in preventing cerebral, cardiovascular, and renal events in patients with hyperuricemia by Kojima, Sunao, MD, PhD, FJCC, Matsui, Kunihiko, MD, PhD, Ogawa, Hisao, MD, PhD, FJCC, Jinnouchi, Hideaki, MD, PhD, Hiramitsu, Shinya, MD, Hayashi, Takahiro, MD, PhD, FJCC, Yokota, Naoto, MD, PhD, Kawai, Naoki, MD, Tokutake, Eiichi, MD, Uchiyama, Kazuaki, MD, PhD, Sugawara, Masahiro, MD, PhD, Kakuda, Hirokazu, MD, Wakasa, Yutaka, MD, Mori, Hisao, MD, PhD, Hisatome, Ichiro, MD, PhD, FJCC, Waki, Masako, MD, PhD, Ohya, Yusuke, MD, PhD, FJCC, Kimura, Kazuo, MD, FJCC, Saito, Yoshihiko, MD, FJCC

“…Abstract Background Since uric acid is associated with cardiovascular and renal disease, a treatment to maintain blood uric acid level may be required in…”
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Efficacy of alogliptin, a dipeptidyl peptidase-4 inhibitor, on glucose parameters, the activity of the advanced glycation end product (AGE) - receptor for AGE (RAGE) axis and albuminuria in Japanese type 2 diabetes by Sakata, Koji, Hayakawa, Manabu, Yano, Yuichiro, Tamaki, Noboru, Yokota, Naoto, Eto, Takuma, Watanabe, Reiko, Hirayama, Naoteru, Matsuo, Takeshi, Kuroki, Kazuo, Sagara, Seiji, Mishima, Osamu, Koga, Masahiro, Nagata, Naoto, Nishino, Yuri, Kitamura, Kazuo, Kario, Kazuomi, Takeuchi, Masayoshi, Yamagishi, Sho-ichi

“…Background To examine the effects of alogliptin, a dipeptidyl peptidase‐4 inhibitor, on glucose parameters, the advanced glycation end product (AGE)‐receptor…”
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Impact of febuxostat on visit-to-visit blood pressure variability: insights from the randomised PRIZE Study by Saito, Yuichi, Tanaka, Atsushi, Koide, Yuji, Yoshida, Hisako, Uchida, Daigaku, Matsunaga, Kazuo, Yokota, Naoto, Ueyama, Chikara, Kobayashi, Yoshio, Node, Koichi

“…ObjectivesAlthough uric acid lowering therapies, including xanthine oxidase (XO) inhibition, may reduce the absolute level of blood pressure (BP), the effect…”
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Protein quality control machinery supports primary ciliogenesis by eliminating GDP-bound Rab8-family GTPases by Takahashi, Toshiki, Shirai, Jun, Matsuda, Miyo, Nakanaga, Sae, Matsushita, Shin, Wakita, Kei, Hayashishita, Mizuki, Suzuki, Rigel, Noguchi, Aya, Yokota, Naoto, Kawahara, Hiroyuki

“…The small GTPase Rab8 plays a vital role in the vesicular trafficking of cargo proteins from the trans-Golgi network to target membranes. Upon reaching its…”
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BAG6/BAT3: emerging roles in quality control for nascent polypeptides by Kawahara, H., Minami, R., Yokota, N.

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Risk Profile and 1-Year Outcome of Newly Diagnosed Atrial Fibrillation in Japan　― Insights From GARFIELD-AF by Koretsune, Yukihiro, Etoh, Takuma, Katsuda, Yousuke, Suetsugu, Tetsuro, Kumeda, Kenshi, Sakuma, Ichiro, Eshima, Kenichi, Shibuya, Mitsuhiro, Ando, Shin-ichi, Yokota, Naoto, Goto, Shinya, Pieper, Karen S., Allu, Jagan, Kakkar, Ajay K., Investigators, for the GARFIELD-AF

“…Background: Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective non-interventional study of stroke…”
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Effects of Proteasome Inhibitors on Fertilization of the Sea Urchin Anthocidaris crassispina by Yokota, Naoto, Sawada, Hitoshi

“…The sperm proteasome has been reported to be involved in sperm penetration through the proteinaceous egg-coat during fertilization in ascidians and mammals…”
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Sperm-specific C-terminal processing of the proteasome PSMA1/α6 subunit by Yokota, Naoto, Kataoka, Yohei, Hashii, Noritaka, Kawasaki, Nana, Sawada, Hitoshi

“…► Ascidian sperm proteasome degrades the egg-coat protein extracellularly during fertilization. ► To explore a transport signal, we investigated the subunits…”
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Identification of testis-specific ubiquitin-conjugating enzyme in the ascidian Ciona intestinalis by Yokota, Naoto, Harada, Yoshito, Sawada, Hitoshi

“…The ubiquitin–proteasome system is known to play a key role in fertilization in ascidians, sea urchins, and mammals. To obtain insights into the…”
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One-year effectiveness and safety of open-label losartan hydrochlorothiazide combination therapy in Japanese patients with hypertension uncontrolled with ARBs or ACE inhibitors by Kita, Toshihiro, Yokota, Naoto, Ichiki, Yoshinari, Ayabe, Takao, Etoh, Takuma, Tamaki, Noboru, Kato, Johji, Eto, Tanenao, Kitamura, Kazuo

“…The long-term antihypertensive efficacy and safety of losartan/hydrochlorothiazide (HCTZ) combinations have not been appropriately evaluated in Japan. In this…”
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Comparison of combination therapies, including the angiotensin receptor blocker olmesartan and either a calcium channel blocker or a thiazide diuretic, in elderly patients with hypertension by Kato, Johji, Yokota, Naoto, Tamaki, Noboru, Kariya, Sumito, Kita, Toshihiro, Ayabe, Takao, Eto, Tanenao, Kitamura, Kazuo

“…The blood pressure goals set for the treatment of hypertensive patients have been lowered in recent guidelines. To reduce blood pressure levels sufficiently,…”
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