Search Results - "Yokoi, Tsuyoshi"

The Emerging Role of Human Esterases by Fukami, Tatsuki, Yokoi, Tsuyoshi

“…In this review, novel aspects of the role of esterases, which contribute to the metabolism of 10% of therapeutic drugs, are described. Esterases hydrolyze the…”
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SC4.3 - Cellular and animal models of idiosyncratic drug-induced liver injury by Yokoi, Tsuyoshi

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Non-P450 Drug-Metabolizing Enzymes: Contribution to Drug Disposition, Toxicity, and Development by Fukami, Tatsuki, Yokoi, Tsuyoshi, Nakajima, Miki

“…Most clinically used drugs are metabolized in the body via oxidation, reduction, or hydrolysis reactions, which are considered phase I reactions. Cytochrome…”
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A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development by Oda, Shingo, Fukami, Tatsuki, Yokoi, Tsuyoshi, Nakajima, Miki

“…UDP-glucuronosyltransferase (UGT) and esterases are recognized as the most important non-P450 enzymes because of their high contribution to drug metabolism…”
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Role of cytochrome P450-mediated metabolism and involvement of reactive metabolite formations on antiepileptic drug-induced liver injuries by Sasaki, Eita, Yokoi, Tsuyoshi

“…Several drugs have been withdrawn from the market or restricted to avoid unexpected adverse outcomes. Drug-induced liver injury (DILI) is a serious issue for…”
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Identification of Specific MicroRNA Biomarkers in Early Stages of Hepatocellular Injury, Cholestasis, and Steatosis in Rats by Kagawa, Takumi, Shirai, Yuji, Oda, Shingo, Yokoi, Tsuyoshi

“…Abstract Recently, studies on circulating microRNAs (miRNAs) as potential biomarkers of drug-induced liver injury (DILI) have received increasing attention. It…”
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Screening of specific inhibitors for human carboxylesterases or arylacetamide deacetylase by Shimizu, Mai, Fukami, Tatsuki, Nakajima, Miki, Yokoi, Tsuyoshi

“…Esterases catalyze the hydrolysis of therapeutic drugs containing esters or amides in their structures. Human carboxylesterase (CES) and arylacetamide…”
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Animal models to predict human risk factors in drug-induced adverse drug reactions by Yokoi, Tsuyoshi

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Recent progress in the use of microRNAs as biomarkers for drug-induced toxicities in contrast to traditional biomarkers: A comparative review by Oda, Shingo, Yokoi, Tsuyoshi

“…microRNAs (miRNAs) are small non-coding RNAs with 18–25 nucleotides. They play key regulatory roles in versatile biological process including development and…”
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microRNAs as Mediators of Drug Toxicity by YOKOI, Tsuyoshi, NAKAJIMA, Miki

“…microRNAs (miRNAs) represent the most abundant class of gene expression regulators that bind complementarily to transcripts to repress their translation or…”
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Toxicological implications of modulation of gene expression by microRNAs by Yokoi, Tsuyoshi, Nakajima, Miki

“…MicroRNAs (miRNAs) are a large family of non-coding RNAs that are evolutionarily conserved, endogenous, and 21-23 nucleotides in length. miRNAs regulate gene…”
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MicroRNA regulates human vitamin D receptor by Mohri, Takuya, Nakajima, Miki, Takagi, Shingo, Komagata, Sayaka, Yokoi, Tsuyoshi

“…Most of the biological effects of 1α,25‐dihydroxyvitamin D3 (1,25(OH)2D3) are elicited by the binding to vitamin D receptor (VDR), which regulates gene…”
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Expression of UGT1A and UGT2B mRNA in Human Normal Tissues and Various Cell Lines by NAKAMURA, Akiko, NAKAJIMA, Miki, YAMANAKA, Hiroyuki, FUJIWARA, Ryoichi, YOKOI, Tsuyoshi

“…UDP-glucuronosyltransferases (UGTs) are major phase II drug metabolism enzymes that catalyze the glucuronidation of numerous endogenous and exogenous…”
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Structure and Protein-Protein Interactions of Human UDP-Glucuronosyltransferases by Fujiwara, Ryoichi, Yokoi, Tsuyoshi, Nakajima, Miki

“…Mammalian UDP-glucuronosyltransferases (UGTs) catalyze the transfer of glucuronic acid from UDP-glucuronic acid to various xenobiotics and endobiotics. Since…”
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MicroRNA regulates the expression of human cytochrome P450 1B1 by TSUCHIYA, Yuki, NAKAJIMA, Miki, TAKAGI, Shingo, TANIYA, Takao, YOKOI, Tsuyoshi

“…MicroRNAs (miRNA) are small noncoding RNAs that regulate gene expression through translational repression or mRNA cleavage. Here, we found that cytochrome P450…”
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Aberrant Activation of Cell-Cycle-Related Kinases and the Potential Therapeutic Impact of PLK1 or CHEK1 Inhibition in Uterine Leiomyosarcoma by Yoshida, Kosuke, Yokoi, Akira, Yamamoto, Tomofumi, Hayashi, Yusuke, Nakayama, Jun, Yokoi, Tsuyoshi, Yoshida, Hiroshi, Kato, Tomoyasu, Kajiyama, Hiroaki, Yamamoto, Yusuke

“…Uterine leiomyosarcoma is among the most aggressive gynecological malignancies. No effective treatment strategies have been established. This study aimed to…”
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Expression of the chrXq27.3 miRNA cluster in recurrent ovarian clear cell carcinoma and its impact on cisplatin resistance by Yoshida, Kosuke, Yokoi, Akira, Sugiyama, Mai, Oda, Shingo, Kitami, Kazuhisa, Tamauchi, Satoshi, Ikeda, Yoshiki, Yoshikawa, Nobuhisa, Nishino, Kimihiro, Niimi, Kaoru, Suzuki, Shiro, Kikkawa, Fumitaka, Yokoi, Tsuyoshi, Kajiyama, Hiroaki

“…Ovarian clear cell carcinoma (OCCC) is a histological subtype of epithelial ovarian cancer and exhibits dismal prognosis due to chemoresistance. Moreover, only…”
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Pharmacological evidence for the involvement of ryanodine receptors in halothane-induced liver injury in mice by Jia, Ru, Oda, Shingo, Yokoi, Tsuyoshi

“…Drug-induced liver injury (DILI) is a major safety concern in drug development. Halothane (HAL), an inhaled anesthetic, induces severe and idiosyncratic liver…”
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Post-transcriptional Regulation of Human Pregnane X Receptor by Micro-RNA Affects the Expression of Cytochrome P450 3A4 by Takagi, Shingo, Nakajima, Miki, Mohri, Takuya, Yokoi, Tsuyoshi

“…Pregnane X receptor (PXR) is a major transcription factor regulating the inducible expression of a variety of transporters and drug-metabolizing enzymes,…”
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Cigarette smoking substantially alters plasma microRNA profiles in healthy subjects by Takahashi, Kei, Yokota, Shin-ichi, Tatsumi, Naoyuki, Fukami, Tatsuki, Yokoi, Tsuyoshi, Nakajima, Miki

“…Circulating microRNAs (miRNAs) are receiving attention as potential biomarkers of various diseases, including cancers, chronic obstructive pulmonary disease,…”
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