Search Results - "Yoji Sato"

Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence by Nishimura, Akiyuki, Shimauchi, Tsukasa, Tanaka, Tomohiro, Shimoda, Kakeru, Toyama, Takashi, Kitajima, Naoyuki, Ishikawa, Tatsuya, Shindo, Naoya, Numaga-Tomita, Takuro, Yasuda, Satoshi, Sato, Yoji, Kuwahara, Koichiro, Kumagai, Yoshito, Akaike, Takaaki, Ide, Tomomi, Ojida, Akio, Mori, Yasuo, Nishida, Motohiro

“…Defective mitochondrial dynamics through aberrant interactions between mitochondria and actin cytoskeleton is increasingly recognized as a key determinant of…”
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Tumorigenicity Studies for Human Pluripotent Stem Cell-Derived Products by Kuroda, Takuya, Yasuda, Satoshi, Sato, Yoji

“…Human pluripotent stem cells (hPSCs), i.e. human embryonic stem cells and human induced pluripotent stem cells, are able to self-renew and differentiate into…”
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Tumorigenicity assay essential for facilitating safety studies of hiPSC-derived cardiomyocytes for clinical application by Ito, Emiko, Miyagawa, Shigeru, Takeda, Maki, Kawamura, Ai, Harada, Akima, Iseoka, Hiroko, Yajima, Shin, Sougawa, Nagako, Mochizuki-Oda, Noriko, Yasuda, Satoshi, Sato, Yoji, Sawa, Yoshiki

“…Transplantation of cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSC-CMs) is a promising treatment for heart failure, but residual…”
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A highly sensitive method for the detection of recombinant PERV-A/C env RNA using next generation sequencing technologies by Kono, Ken, Kataoka, Kiyoko, Yuan, Yuzhe, Yusa, Keisuke, Uchida, Kazuhisa, Sato, Yoji

“…Several xenogenic cell-based therapeutic products are currently under development around the world for the treatment of human diseases. Porcine islet cell…”
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Establishment of the National Consortium for Regenerative Medicine and National Regenerative Medicine Database in Japan by Okada, Kiyoshi, Sato, Yoji, Sugiyama, Daisuke, Sawa, Yoshiki

“…With its aim to regain the function of organs that are damaged by illness or injury, regenerative medicine has become the global focus of research. To…”
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SALL3 expression balance underlies lineage biases in human induced pluripotent stem cell differentiation by Kuroda, Takuya, Yasuda, Satoshi, Tachi, Shiori, Matsuyama, Satoko, Kusakawa, Shinji, Tano, Keiko, Miura, Takumi, Matsuyama, Akifumi, Sato, Yoji

“…Clinical applications of human induced pluripotent stem cells (hiPSCs) are expected, but hiPSC lines vary in their differentiation propensity. For efficient…”
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Tumorigenicity-associated characteristics of human iPS cell lines by Yasuda, Satoshi, Kusakawa, Shinji, Kuroda, Takuya, Miura, Takumi, Tano, Keiko, Takada, Nozomi, Matsuyama, Satoko, Matsuyama, Akifumi, Nasu, Michiyo, Umezawa, Akihiro, Hayakawa, Takao, Tsutsumi, Hideki, Sato, Yoji

“…Human induced pluripotent stem cells (hiPSCs) represent promising raw materials of human cell-based therapeutic products (hCTPs). As undifferentiated hiPSCs…”
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TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling by Kitajima, Naoyuki, Numaga-Tomita, Takuro, Watanabe, Masahiko, Kuroda, Takuya, Nishimura, Akiyuki, Miyano, Kei, Yasuda, Satoshi, Kuwahara, Koichiro, Sato, Yoji, Ide, Tomomi, Birnbaumer, Lutz, Sumimoto, Hideki, Mori, Yasuo, Nishida, Motohiro

“…Reactive oxygen species (ROS) produced by NADPH oxidase 2 (Nox2) function as key mediators of mechanotransduction during both physiological adaptation to…”
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A selective cytotoxic adenovirus vector for concentration of pluripotent stem cells in human pluripotent stem cell-derived neural progenitor cells by Hirai, Takamasa, Kono, Ken, Sawada, Rumi, Kuroda, Takuya, Yasuda, Satoshi, Matsuyama, Satoko, Matsuyama, Akifumi, Koizumi, Naoya, Utoguchi, Naoki, Mizuguchi, Hiroyuki, Sato, Yoji

“…Highly sensitive detection of residual undifferentiated pluripotent stem cells is essential for the quality and safety of cell-processed therapeutic products…”
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Ultra-sensitive detection of tumorigenic cellular impurities in human cell-processed therapeutic products by digital analysis of soft agar colony formation by Kusakawa, Shinji, Yasuda, Satoshi, Kuroda, Takuya, Kawamata, Shin, Sato, Yoji

“…Contamination with tumorigenic cellular impurities is one of the most pressing concerns for human cell-processed therapeutic products (hCTPs). The soft agar…”
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Highly sensitive in vitro methods for detection of residual undifferentiated cells in retinal pigment epithelial cells derived from human iPS cells by Kuroda, Takuya, Yasuda, Satoshi, Kusakawa, Shinji, Hirata, Naoya, Kanda, Yasunari, Suzuki, Kazuhiro, Takahashi, Masayo, Nishikawa, Shin-Ichi, Kawamata, Shin, Sato, Yoji

“…Human induced pluripotent stem cells (hiPSCs) possess the capabilities of self-renewal and differentiation into multiple cell types, and they are free of the…”
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TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis by Numaga-Tomita, Takuro, Kitajima, Naoyuki, Kuroda, Takuya, Nishimura, Akiyuki, Miyano, Kei, Yasuda, Satoshi, Kuwahara, Koichiro, Sato, Yoji, Ide, Tomomi, Birnbaumer, Lutz, Sumimoto, Hideki, Mori, Yasuo, Nishida, Motohiro

“…Structural cardiac remodeling, accompanying cytoskeletal reorganization of cardiac cells, is a major clinical outcome of diastolic heart failure. A highly…”
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A novel in vitro method for detecting undifferentiated human pluripotent stem cells as impurities in cell therapy products using a highly efficient culture system by Tano, Keiko, Yasuda, Satoshi, Kuroda, Takuya, Saito, Hirohisa, Umezawa, Akihiro, Sato, Yoji

“…Innovative applications of cell therapy products (CTPs) derived from human pluripotent stem cells (hPSCs) in regenerative medicine are currently being…”
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Application of the Thermal Analysis of Frozen Aqueous Solutions to Assess the Miscibility of Hyaluronic Acid and Polymers Used for Dissolving Microneedles by Izutsu, Ken-Ichi, Yoshida, Hiroyuki, Abe, Yasuhiro, Yamamoto, Eiichi, Sato, Yoji, Ando, Daisuke

“…The combination of multiple polymers is anticipated to serve as a means to diversify the physical properties and functionalities of dissolving microneedles…”
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Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound by Kiyonaka, Shigeki, Kato, Kenta, Nishida, Motohiro, Mio, Kazuhiro, Numaga, Takuro, Sawaguchi, Yuichi, Yoshida, Takashi, Wakamori, Minoru, Mori, Emiko, Numata, Tomohiro, Ishii, Masakazu, Takemoto, Hiroki, Ojida, Akio, Watanabe, Kenta, Uemura, Aya, Kurose, Hitoshi, Morii, Takashi, Kobayashi, Tsutomu, Sato, Yoji, Sato, Chikara, Hamachi, Itaru, Mori, Yasuo

“…Canonical transient receptor potential (TRPC) channels control influxes of Ca²⁺ and other cations that induce diverse cellular processes upon stimulation of…”
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ROR2 expression predicts human induced pluripotent stem cell differentiation into neural stem/progenitor cells and GABAergic neurons by Kuroda, Takuya, Yasuda, Satoshi, Matsuyama, Satoko, Miura, Takumi, Sawada, Rumi, Matsuyama, Akifumi, Yamamoto, Yumiko, Morioka, Masaki Suimye, Kawaji, Hideya, Kasukawa, Takeya, Itoh, Masayoshi, Akutsu, Hidenori, Kawai, Jun, Sato, Yoji

“…Despite the development of various in vitro differentiation protocols for the efficient derivation of specific cell types, human induced pluripotent stem cell…”
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Myocardial TRPC6-mediated Zn2+ influx induces beneficial positive inotropy through β-adrenoceptors by Oda, Sayaka, Nishiyama, Kazuhiro, Furumoto, Yuka, Yamaguchi, Yohei, Nishimura, Akiyuki, Tang, Xiaokang, Kato, Yuri, Numaga-Tomita, Takuro, Kaneko, Toshiyuki, Mangmool, Supachoke, Kuroda, Takuya, Okubo, Reishin, Sanbo, Makoto, Hirabayashi, Masumi, Sato, Yoji, Nakagawa, Yasuaki, Kuwahara, Koichiro, Nagata, Ryu, Iribe, Gentaro, Mori, Yasuo, Nishida, Motohiro

“…Baroreflex control of cardiac contraction (positive inotropy) through sympathetic nerve activation is important for cardiocirculatory homeostasis. Transient…”
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Development of selective cytotoxic viral vectors for concentration of undifferentiated cells in cardiomyocytes derived from human induced pluripotent stem cells by Kono, Ken, Sawada, Rumi, Kuroda, Takuya, Yasuda, Satoshi, Matsuyama, Satoko, Matsuyama, Akifumi, Mizuguchi, Hiroyuki, Sato, Yoji

“…Cell-processed therapeutic products (CTPs) derived from human pluripotent stem cells (hPSCs) have innovative applications in regenerative medicine. However,…”
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Estimated number of off‐target candidate sites for antisense oligonucleotides in human mRNA sequences by Yoshida, Tokuyuki, Naito, Yuki, Sasaki, Kiyomi, Uchida, Eriko, Sato, Yoji, Naito, Mikihiko, Kawanishi, Toru, Obika, Satoshi, Inoue, Takao

“…Antisense oligonucleotide (ASO) therapeutics are single‐stranded oligonucleotides which bind to RNA through sequence‐specific Watson–Crick base pairings. A…”
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Tumorigenicity assessment of human cell-processed therapeutic products by Yasuda, Satoshi, Sato, Yoji

“…Human pluripotent stem cells (hPSCs) are expected to be sources of various cell types used for cell therapy, although hPSCs are intrinsically tumorigenic and…”
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