Search Results - "Yohrling, G."

Identification of substrate orienting and phosphorylation sites within tryptophan hydroxylase using homology-based molecular modeling by Jiang, G.C.-T, Yohrling, G.J, Schmitt, I.V.J.D, Vrana, K.E

“…Tryptophan hydroxylase (TPH) is the initial and rate-limiting enzyme in the biosynthesis of serotonin. The inherent instability of TPH has prevented a…”
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Huntingtin inclusions do not down-regulate specific genes in the R6/2 Huntington's disease mouse by Sadri-Vakili, G., Menon, A. S., Farrell, L. A., Keller-McGandy, C. E., Cantuti-Castelvetri, I., Standaert, D. G., Augood, S. J., Yohrling, G. J., Cha, J.-H. J.

“…Transcriptional dysregulation is a central pathogenic mechanism in Huntington's disease (HD); HD and transgenic mouse models of HD demonstrate down‐regulation…”
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PND17 HEALTHCARE UTILIZATION AND COSTS BY DISEASE STAGE IN BENEFICIARIES WITH HUNTINGTON’S DISEASE IN THE US MEDICARE POPULATION by Exuzides, A., Crowell, V., Reddy, S.R., Chang, E., Yohrling, G.

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PND34 Healthcare Utilization and Costs at End-of-Life Among US Medicaid Beneficiaries with Huntington's Disease by Reddy, S., Exuzides, A., Chang, E., Ta, J., Patel, A., Paydar, C., Yohrling, G.

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Intersubunit binding domains within tyrosine hydroxylase and tryptophan hydroxylase by Yohrling IV, G.J., Jiang, G.C.-T., Mockus, S.M., Vrana, K.E.

“…Tryptophan hydroxylase (TPH), the rate‐limiting enzyme in the biosynthesis of the neurotransmitter serotonin (5‐HT) belongs to the aromatic amino acid…”
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Identification of amino-terminal sequences contributing to tryptophan hydroxylase tetramer formation by Yohrling, 4th, G J, Mockus, S M, Vrana, K E

“…Tryptophan hydroxylase (TPH) catalyzes the rate-limiting step in the biosynthesis of serotonin. In the rabbit, TPH exists as a tetramer of four identical…”
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Tyrosine hydroxylase and tryptophan hydroxylase do not form heterotetramers by Mockus, S M, Yohrling, 4th, G J, Vrana, K E

“…Tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) both contain a C-terminal tetramerization domain composed of a leucine heptad repeat embedded within…”
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Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease by Chen-Plotkin, Alice S., Sadri-Vakili, Ghazaleh, Yohrling, George J., Braveman, Melissa W., Benn, Caroline L., Glajch, Kelly E., DiRocco, Derek P., Farrell, Laurie A., Krainc, Dimitri, Gines, Silvia, MacDonald, Marcy E., Cha, Jang-Ho J.

“…Huntington's disease (HD) is a neurodegenerative disease caused by expansion of a polyglutamine tract within the huntingtin protein. Transcriptional…”
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A cocaine analog, 2beta-propanoyl-3beta-(4-tolyl)-tropane (PTT), reduces tyrosine hydroxylase in the mesolimbic dopamine pathway by Freeman, W M, Yohrling, G J, Daunais, J B, Gioia, L, Hart, S L, Porrino, L J, Davies, H M, Vrana, K E

“…Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis. Previously published results have established that chronic cocaine…”
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Inhibition of tryptophan hydroxylase activity and decreased 5‐HT1A receptor binding in a mouse model of Huntington's disease by Yohrling IV, George J., Jiang, George C.‐T., DeJohn, Molly M., Robertson, Daniel J., Vrana, Kent E., Cha, Jang‐Ho J.

“…The pathogenic mechanisms of the mutant huntingtin protein that cause Huntington's disease (HD) are unknown. Previous studies have reported significant…”
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Mutant huntingtin increases nuclear corepressor function and enhances ligand-dependent nuclear hormone receptor activation by Yohrling, George J, Farrell, Laurie A, Hollenberg, Anthony N, Cha, Jang-Ho J

“…There is increasing evidence that transcriptional dysregulation is important in Huntington’s disease pathogenesis. The transcriptional protein, nuclear…”
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Mutation measurement in mammalian cells. IV: Comparison of gamma-ray and chemical mutagenesis by Puck, T T, Johnson, R, Webb, P, Yohrling, G

“…The interaction of chemical mutagens with mammalian cells is much more complex than that of gamma-irradiation because of the different ways in which chemical…”
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Inhibition of tryptophan hydroxylase activity and decreased 5-HT sub(1A) receptor binding in a mouse model of Huntington's disease by Yohrling, GJ IV, Jiang, GC-T, DeJohn, M M, Robertson, D J, Vrana, KE, Cha, J-HJ

“…The pathogenic mechanisms of the mutant huntingtin protein that cause Huntington's disease (HD) are unknown. Previous studies have reported significant…”
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Analysis of cellular, transgenic and human models of Huntington's disease reveals tyrosine hydroxylase alterations and substantia nigra neuropathology by Yohrling, George J., Jiang, George C.-T., DeJohn, Molly M., Miller, David W., Young, Anne B., Vrana, Kent E., Cha, Jang-Ho J.

“…Huntington's disease (HD) is a progressive, autosomal dominant neurodegenerative disorder that is pathologically characterized by a striatal-specific…”
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Intersubunit Binding Domains Within Tyrosine Hydroxylase and Tryptophan Hydroxylase by Yohrling, GJ IV, Jiang, GC-T, Mockus, S M, Vrana, KE

“…Tryptophan hydroxylase (TPH), the rate-limiting enzyme in the biosynthesis of the neurotransmitter serotonin (5-HT) belongs to the aromatic amino acid…”
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Identification of substrate orienting and phosphorylation sites within tryptophan hydroxylase using homology-based molecular molecular modeling by Jiang, G.C.-T., Yohrling, G.J., Schmitt, I.V.J.D., Vrana, K.E.

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A cocaine analog, 2β-propanoyl-3β-(4-tolyl)-tropane (PTT), reduces tyrosine hydroxylase in the mesolimbic dopamine pathway by Freeman, Willard M, Yohrling, George J, Daunais, James B, Gioia, Lynda, Hart, Stephanie L, Porrino, Linda J, Davies, Huw M.L, Vrana, Kent E

“…Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis. Previously published results have established that chronic cocaine…”
Get full text