Cross-Reactive Plasmonic Aptasensors for Controlled Substance Identification

Cross-Reactive Plasmonic Aptasensors for Controlled Substance Identification

In this work, we developed an assay to determine if an arbitrary white powder is a controlled substance, given the plasmonic response of aptamer-gold nanoparticle conjugates (Apt-AuNPs). Toward this end, we designed Apt-AuNPs with specific a response to common controlled substances without cross rea...

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Bibliographic Details
Published in:Sensors (Basel, Switzerland) Vol. 17; no. 9; p. 1935
Main Authors: Yoho, Joshua N, Geier, Brian, Grigsby, Claude C, Hagen, Joshua A, Chávez, Jorge L, Kelley-Loughnane, Nancy
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 23-08-2017
MDPI
Subjects:
aptamer
Assaying
Cocaine
colorimetric
Crime scenes
cross-reactive
Design
Drug abuse
Fillers
Fingerprints
Formulations
Gold
gold nanoparticle
Identification
illicit drugs
Law enforcement
Ligands
LSD
Lysergic acid diethylamide
Morphine
Nanomaterials
Nanoparticles
plasmonic sensor
Sensors
Statistical analysis
Statistical methods
illicit drugs
colorimetric
plasmonic sensor
aptamer
gold nanoparticle
cross-reactive
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Description
Summary:In this work, we developed an assay to determine if an arbitrary white powder is a controlled substance, given the plasmonic response of aptamer-gold nanoparticle conjugates (Apt-AuNPs). Toward this end, we designed Apt-AuNPs with specific a response to common controlled substances without cross reactivity to chemicals typically used as fillers in street formulations. Plasmonic sensor variation was shown to produce unique data fingerprints for each chemical analyzed, supporting the application of multivariate statistical techniques to annotate unknown samples by chemical similarity. Importantly, the assay takes less than fifteen minutes to run, and requires only a few micrograms of the material, making the proposed assay easily deployable in field operations.
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Current address: Department of Chemistry and Center for Nanostructured Electronic Materials, University of Florida, Gainesville, FL 32611, USA
ISSN:1424-8220
1424-8220
DOI:10.3390/s17091935