Search Results - "Yogo, Yuya"
-
1
Comparison of the stability of CYP105A1 and its variants engineered for production of active forms of vitamin D
Published in Bioscience, biotechnology, and biochemistry (21-03-2022)“…CYP105A1 from Streptomyces griseolus converts vitamin D3 to its biologically active form, 1α,25-dihydroxy vitamin D3. R73A/R84A mutation enhanced the 1α- and…”
Get full text
Journal Article -
2
Metabolism of non-steroidal anti-inflammatory drugs (NSAIDs) by Streptomyces griseolus CYP105A1 and its variants
Published in Drug metabolism and pharmacokinetics (01-08-2022)“…In the field of drug development, technology for producing human metabolites at a low cost is required. In this study, we explored the possibility of using…”
Get full text
Journal Article -
3
Sequential hydroxylation of vitamin D 2 by a genetically engineered CYP105A1
Published in Biochemical and biophysical research communications (01-05-2016)Get full text
Journal Article -
4
Production of an active form of vitamin D 2 by genetically engineered CYP105A1
Published in Biochemical and biophysical research communications (01-04-2017)“…Our previous studies revealed that CYP105A1 can convert vitamin D (VD3) to its active form, 1α,25-dihydroxyvitamin D (1,25D3). Site-directed mutagenesis of…”
Get full text
Journal Article -
5
Production of an active form of vitamin D2 by genetically engineered CYP105A1
Published in Biochemical and biophysical research communications (29-04-2017)“…Our previous studies revealed that CYP105A1 can convert vitamin D3 (VD3) to its active form, 1α,25-dihydroxyvitamin D3 (1,25D3). Site-directed mutagenesis of…”
Get full text
Journal Article -
6
Sequential hydroxylation of vitamin D2 by a genetically engineered CYP105A1
Published in Biochemical and biophysical research communications (13-05-2016)“…Our previous studies revealed that the double variants of CYP105A1— R73A/R84A and R73V/R84A—show high levels of activity with respect to conversion of vitamin…”
Get full text
Journal Article