Search Results - "Yogeeswari, Perumal"

Betulinic acid and its derivatives: a review on their biological properties by Yogeeswari, Perumal, Sriram, Dharmarajan

“…Betulinic acid is a naturally occurring pentacyclic triterpenoid and has been shown to exhibit a variety of biological activities including inhibition of human…”
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Discovery of Antimycobacterial Spiro-piperidin-4-ones: An Atom Economic, Stereoselective Synthesis, and Biological Intervention by Kumar, Raju Ranjith, Perumal, Subbu, Senthilkumar, Palaniappan, Yogeeswari, Perumal, Sriram, Dharmarajan

“…An atom economic and stereoselective synthesis of several spiro-piperidin-4-ones through 1,3-dipolar cycloaddition of azomethine ylides generated in situ from…”
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Design, synthesis and biological evaluation of imidazo[2,1-b]thiazole and benzo[d]imidazo[2,1-b]thiazole derivatives as Mycobacterium tuberculosis pantothenate synthetase inhibitors by Samala, Ganesh, Devi, Parthiban Brindha, Saxena, Shalini, Meda, Nikhila, Yogeeswari, Perumal, Sriram, Dharmarajan

“…Compound 5bc emerged as potent compound active against MTB PS with IC50 of 0.53±0.13μM, MIC of 3.53μM, 2.1log reduction against nutrient starved MTB. It also…”
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Design, Synthesis, and Structure–Activity Correlations of Novel Dibenzo[b,d]furan, Dibenzo[b,d]thiophene, and N-Methylcarbazole Clubbed 1,2,3-Triazoles as Potent Inhibitors of Mycobacterium tuberculosis by Patpi, Santhosh Reddy, Pulipati, Lokesh, Yogeeswari, Perumal, Sriram, Dharmarajan, Jain, Nishant, Sridhar, Balasubramanian, Murthy, Ramalinga, T, Anjana Devi, Kalivendi, Shasi Vardhan, Kantevari, Srinivas

“…A molecular hybridization approach is an emerging structural modification tool to design new molecules with improved pharmacophoric properties. In this study,…”
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Design, development of new synthetic methodology, and biological evaluation of substituted quinolines as new anti-tubercular leads by Tanwar, Babita, Kumar, Asim, Yogeeswari, Perumal, Sriram, Dharmarajan, Chakraborti, Asit K.

“…[Display omitted] Two series of quinoline-based compounds were designed, synthesised and evaluated for anti-tubercular activity against Mycobacterium…”
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Design, Synthesis, and Evaluation of Thiol-Activated Sources of Sulfur Dioxide (SO2) as Antimycobacterial Agents by Malwal, Satish R, Sriram, Dharmarajan, Yogeeswari, Perumal, Konkimalla, V. Badireenath, Chakrapani, Harinath

“…Here, 2,4-dinitrophenylsulfonamides with tunable cysteine-activated SO2 release profiles with half-lives of SO2 release varying from 2 to 63 min are reported…”
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A facile synthesis and antimycobacterial evaluation of novel spiro-pyrido-pyrrolizines and pyrrolidines by Ranjith Kumar, Raju, Perumal, Subbu, Senthilkumar, Palaniappan, Yogeeswari, Perumal, Sriram, Dharmarajan

“…An efficient synthesis of 1-methyl-3-[( E)-arylmethylidene]tetrahydro-4(1 H)-pyridinones was achieved by the reaction of 1-methyl-4-piperidone and aromatic…”
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Synthesis of novel cytotoxic tetracyclic acridone derivatives and study of their molecular docking, ADMET, QSAR, bioactivity and protein binding properties by Veligeti, Rajkumar, Madhu, Rajesh Bagepalli, Anireddy, Jayashree, Pasupuleti, Visweswara Rao, Avula, Vijaya Kumar Reddy, Ethiraj, Krishna S., Uppalanchi, Srinivas, Kasturi, Sivaprasad, Perumal, Yogeeswari, Anantaraju, Hasitha Shilpa, Polkam, Naveen, Guda, Mallilkarjuna Reddy, Vallela, Swetha, Zyryanov, Grigory Vasilievich

“…Acridone based synthetic and natural products with inherent anticancer activity advancing the research and generating a large number of structurally…”
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Targeting hexokinase 2 for oral cancer therapy: structure-based design and validation of lead compounds by Chakraborty, Purbali, Lubna, Syeda, Bhuin, Shouvik, K, Deepika, Chakravarty, Manab, Jamma, Trinath, Yogeeswari, Perumal

“…The pursuit of small molecule inhibitors targeting hexokinase 2 (HK2) has significantly captivated the field of cancer drug discovery. Nevertheless, the…”
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Design and synthesis of oxaprozin‐1,3,4‐oxadiazole hybrids as potential anticancer and antibacterial agents by Rayam, Parsharamulu, Polkam, Naveen, Kuntala, Naveen, Banothu, Venkanna, Anantaraju, Hasitha Shilpa, Perumal, Yogeeswari, Balasubramanian, Sridhar, Anireddy, Jaya Shree

“…In the present study, we report design, synthesis and screening of new novel 5‐substituted‐2‐mercapto‐1,3,4‐oxadiazole analogues appended to oxaprozin for…”
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An atom efficient, solvent-free, green synthesis and antimycobacterial evaluation of 2-amino-6-methyl-4-aryl-8-[(E)-arylmethylidene]-5,6,7,8 -tetrahydro -4H -pyrano [3,2 -c ]pyridine -3 -carbonitriles by RAJU RANJITH KUMAR, PERUMAL, Subbu, SENTHILKUMAR, Palaniappan, YOGEESWARI, Perumal, SRIRAM, Dharmarajan

“…An atom efficient, green protocol for the synthesis of fifteen…”
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Depletion of M. tuberculosis GlmU from Infected Murine Lungs Effects the Clearance of the Pathogen by Soni, Vijay, Upadhayay, Sandeep, Suryadevara, Priyanka, Samla, Ganesh, Singh, Archana, Yogeeswari, Perumal, Sriram, Dharmarajan, Nandicoori, Vinay Kumar

“…M. tuberculosis N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmUMtb) is a bi-functional enzyme engaged in the synthesis of two metabolic intermediates…”
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Design and synthesis of anticonvulsants from a combined phthalimide–GABA–anilide and hydrazone pharmacophore by Ragavendran, Jegadeesan Vaigunda, Sriram, Dharmarajan, Patel, Sravan Kumar, Reddy, Ingala Vikram, Bharathwajan, Narayanan, Stables, James, Yogeeswari, Perumal

“…Two series of pharmacophoric hybrids of phthalimide–GABA–anilides/hydrazones were designed and synthesized and evaluated for their anticonvulsant and…”
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A highly atom economic, chemo-, regio- and stereoselective synthesis and evaluation of spiro-pyrrolothiazoles as antitubercular agents by Karthikeyan, Subramanian Vedhanarayanan, Bala, Balasubramanian Devi, Raja, Velanganni Paul Alex, Perumal, Subbu, Yogeeswari, Perumal, Sriram, Dharmarajan

“…The 1,3-dipolar cycloaddition of azomethine ylides derived from substituted isatins and 1,3-thiazolane-4-carboxylic acid to a series of 1-methyl-3,5-bis[(…”
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Synthesis and antitubercular evaluation of novel dibenzo[b,d]thiophene tethered imidazo[1,2-a]pyridine-3-carboxamides by Pulipati, Lokesh, Sridevi, Jonnalagadda Padma, Yogeeswari, Perumal, Sriram, Dharmarajan, Kantevari, Srinivas

“…[Display omitted] A series of novel dibenzo[b,d]thiophene tethered imidazo[1,2-a]pyridine carboxamides 7a–s were designed and synthesized. The required…”
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Isonicotinic acid hydrazide derivatives: synthesis, antimicrobial activity, and QSAR studies by Judge, Vikramjeet, Narasimhan, Balasubramanian, Ahuja, Munish, Sriram, Dharmarajan, Yogeeswari, Perumal, De Clercq, Erik, Pannecouque, Christophe, Balzarini, Jan

“…A series of isonicotinic acid hydrazide derivatives ( 1 – 19 ) was synthesized and tested in vitro for antimycobacterial activity against Mycobacterium…”
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Rational design, synthesis and evaluation of novel-substituted 1,2,3-triazolylmethyl carbazoles as potent inhibitors of Mycobacterium tuberculosis by Surineni, Goverdhan, Yogeeswari, Perumal, Sriram, Dharmarajan, Kantevari, Srinivas

“…Herein, we describe synthesis and antitubercular evaluation of novel-substituted 1,2,3-triazolylmethyl carbazoles rationally designed by incorporating two…”
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Click-based synthesis and antitubercular evaluation of dibenzofuran tethered thiazolyl-1,2,3-triazolyl acetamides by Surineni, Goverdhan, Yogeeswari, Perumal, Sriram, Dharmarajan, Kantevari, Srinivas

“…[Display omitted] A series of novel dibenzofuran tethered thiazolyl-1,2,3-triazolyl acetamides, designed by assembling antitubercular pharmacophoric fragments,…”
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A microwave-assisted facile regioselective Fischer indole synthesis and antitubercular evaluation of novel 2-aryl-3,4-dihydro-2H-thieno[3,2-b]indoles by Karthikeyan, Subramanian Vedhanarayanan, Perumal, Subbu, Shetty, Krithika Arun, Yogeeswari, Perumal, Sriram, Dharmarajan

“…A series of novel 2-aryl-3,4-dihydro-2H-thieno[3,2-b]indoles has been synthesised regioselectively in good yields from the reaction of…”
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Discovery of New Antitubercular Oxazolyl Thiosemicarbazones by Sriram, Dharmarajan, Yogeeswari, Perumal, Thirumurugan, Rathinasababathy, Pavana, Roheet Kumar

“…Twenty 4-(5-cyclobutyloxazol-2-yl)thiosemicarbazones were synthesized and evaluated for preliminary in vitro and in vivo activity against Mycobacterium…”
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