Autonomous Growth of Committed Hematopoietic Progenitors From Peripheral Blood of Workers Exposed to Low Levels of Benzene

Autonomous Growth of Committed Hematopoietic Progenitors From Peripheral Blood of Workers Exposed to Low Levels of Benzene

We investigated whether exposure to low levels of benzene (geometric mean of exposures = 0.28-0.41 parts per million) results in perturbations of the hemopoietic system found in patients with myeloproliferative diseases. Erythroid (BFU-E) and granulocyte–monocyte (CFU-GM) colonies from peripheral bl...

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Bibliographic Details
Published in:Journal of occupational and environmental medicine Vol. 46; no. 1; pp. 27 - 29
Main Authors: Quitt, Miriam, Cassel, Aliza, Yoffe, Anatol, Anatol, Anna Maria, Froom, Paul
Format: Journal Article
Language:English
Published: Hagerstown, MD Lippincott Williams & Wilkins 01-01-2004
The American College of Occupational and Environmental Medicine
Lippincott Williams & Wilkins Ovid Technologies
Subjects:
Adult
Benzene - adverse effects
Biological and medical sciences
Blood
Chemical and industrial products toxicology. Toxic occupational diseases
Cytokines
Disease
Erythroid Precursor Cells - drug effects
Erythroid Precursor Cells - physiology
Hematopoiesis - drug effects
hemopoiesis
Humans
Hydrocarbons
Male
Medical sciences
Myeloproliferative Disorders - chemically induced
Occupational Exposure - adverse effects
Occupational hazards
ORIGINAL ARTICLES
Petroleum
Toxicology
Various organic compounds
Human
Myeloproliferative syndrome
Hematopoiesis
Toxicity
Benzene
Low dose
Occupational exposure
Occupational medicine
Progenitor cell
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Summary:We investigated whether exposure to low levels of benzene (geometric mean of exposures = 0.28-0.41 parts per million) results in perturbations of the hemopoietic system found in patients with myeloproliferative diseases. Erythroid (BFU-E) and granulocyte–monocyte (CFU-GM) colonies from peripheral blood were grown in methylcellulose with and without the addition of cytokines (erythropoietin and granulocyte-stimulating factor). Colony growth from 17 workers exposed to low levels of benzene was compared with 20 healthy control subjects. Exposed workers had significantly increased growth of autonomous BFU-E and unstimulated CFU-GM when compared with the control subjects. Unexposed smokers had increased colony growth without the addition of cytokines. Colony growth was not significantly different between the groups after the addition of cytokines. Workers exposed to low concentrations of benzene and unexposed smokers have increased cytokine-independent hematopoiesis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1076-2752
1536-5948
DOI:10.1097/01.jom.0000106009.06837.38