Search Results - "Yoda, Noriaki"

Prediction of drug intestinal absorption in human using the Ussing chamber system: A comparison of intestinal tissues from animals and humans by Miyake, Masateru, Koga, Toshihisa, Kondo, Satoshi, Yoda, Noriaki, Emoto, Chie, Mukai, Tadashi, Toguchi, Hajime

“…An adequate evaluation system for drug intestinal absorption is essential in the pharmaceutical industry. Previously, we established a novel prediction system…”
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Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia by Nishizawa, Kei, Yoda, Noriaki, Morokado, Fumi, Komori, Hisakazu, Nakanishi, Takeo, Tamai, Ikumi

“…The effects of hyperuricemia on the expression of kidney drug transporters and on the pharmacokinetics of several substrate drugs were examined. We first…”
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Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5′-flanking region by Yoshinari, Kouichi, Yoda, Noriaki, Toriyabe, Takayoshi, Yamazoe, Yasushi

“…Phenobarbital has long been known to increase cellular levels of CYP1A1 and CYP1A2 possibly through a pathway(s) independent of aryl hydrocarbon receptor. We…”
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Delamanid Does Not Inhibit or Induce Cytochrome P450 Enzymes in Vitro by Shimokawa, Yoshihiko, Sasahara, Katsunori, Yoda, Noriaki, Mizuno, Katsuhiko, Umehara, Ken

“…Delamanid is a new drug for the treatment of multidrug-resistant tuberculosis. Individuals who are co-infected with human immunodeficiency virus and…”
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Metabolic Mechanism of Delamanid, a New Anti-Tuberculosis Drug, in Human Plasma by Shimokawa, Yoshihiko, Sasahara, Katsunori, Koyama, Noriyuki, Kitano, Kazuyoshi, Shibata, Masakazu, Yoda, Noriaki, Umehara, Ken

“…The metabolism of delamanid (OPC-67683, Deltyba), a novel treatment of multidrug-resistant tuberculosis, was investigated in vitro using plasma and purified…”
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Inhibitory Potential of Twenty Five Anti-tuberculosis Drugs on CYP Activities in Human Liver Microsomes by Shimokawa, Yoshihiko, Yoda, Noriaki, Kondo, Satoshi, Yamamura, Yoshiya, Takiguchi, Yoshiharu, Umehara, Ken

“…The direct inhibitory potential of twenty five anti-tuberculosis drugs on eight CYP-specific reactions in human liver microsomes was investigated to predict in…”
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Comparison of p450 enzymes between cynomolgus monkeys and humans: p450 identities, protein contents, kinetic parameters, and potential for inhibitory profiles by Emoto, Chie, Yoda, Noriaki, Uno, Yasuhiro, Iwasaki, Kazuhide, Umehara, Ken, Kashiyama, Eiji, Yamazaki, Hiroshi

“…Cynomolgus monkeys are used to predict human pharmacokinetic and/or toxic profiles in the drug developmental stage. Cynomolgus P450s exhibit a high degree of…”
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Delamanid Does Not Inhibit or Induce Cytochrome P450 Enzymes in Vitro by Yoshihiko Shimokawa, Katsunori Sasahara, Noriaki Yoda, Katsuhiko Mizuno, Ken Umehara

“…Delamanid is a new drug for the treatment of multidrug-resistant tuberculosis. Individuals who are co-infected with human immunodeficiency virus and…”
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Evaluation of intestinal metabolism and absorption using the Ussing chamber system equipped with intestinal tissue from rats and dogs by Miyake, Masateru, Kondo, Satoshi, Koga, Toshihisa, Yoda, Noriaki, Nakazato, Satoru, Emoto, Chie, Mukai, Tadashi, Toguchi, Hajime

“…[Display omitted] The purpose of this study was to evaluate the intestinal metabolism and absorption in a mini-Ussing chamber equipped with animal intestinal…”
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Absorption, distribution and excretion of the anti‐tuberculosis drug delamanid in rats: Extensive tissue distribution suggests potential therapeutic value for extrapulmonary tuberculosis by Shibata, Masakazu, Shimokawa, Yoshihiko, Sasahara, Katsunori, Yoda, Noriaki, Sasabe, Hiroyuki, Suzuki, Mitsunari, Umehara, Ken

“…Delamanid (OPC‐67683, Deltyba™, nitro‐dihydro‐imidazooxazoles derivative) is approved for the treatment of adult pulmonary multidrug‐resistant tuberculosis…”
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Characterization of intestinal and hepatic P450 enzymes in cynomolgus monkeys with typical substrates and inhibitors for human P450 enzymes by Yoda, Noriaki, Emoto, Chie, Date, Shoichi, Kondo, Satoshi, Miyake, Masateru, Nakazato, Satoru, Umehara, Ken, Kashiyama, Eiji

“…Cynomolgus monkeys are widely used to predict human pharmacokinetic and/or toxic profiles in the drug developmental stage. Characterization of cynomolgus…”
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