Search Results - "Yiyang Gong"
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The evolving capabilities of rhodopsin-based genetically encoded voltage indicators
Published in Current opinion in chemical biology (01-08-2015)“…•Rhodopsin sensors have large dynamic range and fast kinetics.•FRET-opsin sensors lead the GEVI class in spike detection SNR metrics.•FRET-opsin sensors are on…”
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A high-speed, bright, red fluorescent voltage sensor to detect neural activity
Published in Scientific reports (04-11-2019)“…Genetically encoded voltage indicators (GEVIs) have emerged as a technology to optically record neural activity with genetic specificity and millisecond-scale…”
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3
A fully water coupled oblique light-sheet microscope
Published in Scientific reports (08-04-2022)“…Recently developed descanned versions of the oblique light-sheet microscope promise to enable high-frame rate volumetric imaging in a variety of convenient…”
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4
Fast and robust active neuron segmentation in two-photon calcium imaging using spatiotemporal deep learning
Published in Proceedings of the National Academy of Sciences - PNAS (23-04-2019)“…Calcium imaging records large-scale neuronal activity with cellular resolution in vivo. Automated, fast, and reliable active neuron segmentation is a critical…”
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5
Offset Drain ZnO Thin-Film Transistors for High-Voltage Operation
Published in IEEE electron device letters (01-08-2017)“…High-voltage thin-film transistors (TFTs) are useful building blocks for thin-film circuits. In this letter, we demonstrate ZnO high-voltage TFTs with offset…”
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6
Identifying properties of pattern completion neurons in a computational model of the visual cortex
Published in PLoS computational biology (06-06-2023)“…Neural ensembles are found throughout the brain and are believed to underlie diverse cognitive functions including memory and perception. Methods to activate…”
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7
Photonic crystal cavities in silicon dioxide
Published in Applied physics letters (18-01-2010)“…One dimensional nanobeam photonic crystal cavities fabricated in silicon dioxide are considered in both simulation and experiment. Quality factors of over 10 4…”
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Accurate neuron segmentation method for one-photon calcium imaging videos combining convolutional neural networks and clustering
Published in Communications biology (09-08-2024)“…One-photon fluorescent calcium imaging helps understand brain functions by recording large-scale neural activities in freely moving animals. Automatic, fast,…”
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Kilohertz two-photon brain imaging in awake mice
Published in Nature methods (01-11-2019)“…Two-photon microscopy is a mainstay technique for imaging in scattering media and normally provides frame-acquisition rates of ~10–30 Hz. To track high-speed…”
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10
Rational engineering of ratiometric calcium sensors with bright green and red fluorescent proteins
Published in Communications biology (29-07-2021)“…Ratiometric genetically encoded calcium indicators (GECIs) record neural activity with high brightness while mitigating motion-induced artifacts. Recently…”
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Decontaminate Traces From Fluorescence Calcium Imaging Videos Using Targeted Non-negative Matrix Factorization
Published in Frontiers in neuroscience (21-01-2022)“…Fluorescence microscopy and genetically encoded calcium indicators help understand brain function by recording large-scale videos in assorted animal models…”
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12
Cell-Type-Specific Optical Recording of Membrane Voltage Dynamics in Freely Moving Mice
Published in Cell (01-12-2016)“…Electrophysiological field potential dynamics are of fundamental interest in basic and clinical neuroscience, but how specific cell types shape these dynamics…”
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13
Boosting exciton mobility approaching Mott-Ioffe-Regel limit in Ruddlesden−Popper perovskites by anchoring the organic cation
Published in Nature communications (29-02-2024)“…Exciton transport in two-dimensional Ruddlesden−Popper perovskite plays a pivotal role for their optoelectronic performance. However, a clear photophysical…”
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14
Genetically Encoded Fluorescent Indicators for Imaging Brain Chemistry
Published in Biosensors (Basel) (11-04-2021)“…Genetically encoded fluorescent indicators, combined with optical imaging, enable the detection of physiologically or behaviorally relevant neural activity…”
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15
Enhanced Archaerhodopsin Fluorescent Protein Voltage Indicators
Published in PloS one (19-06-2013)“…A longstanding goal in neuroscience has been to develop techniques for imaging the voltage dynamics of genetically defined subsets of neurons. Optical sensors…”
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16
Design of plasmon cavities for solid-state cavity quantum electrodynamics applications
Published in Applied physics letters (15-01-2007)“…Research on photonic cavities with low mode volume and high quality factor garners much attention because of applications ranging from optoelectronics to…”
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17
Segmentation of neurons from fluorescence calcium recordings beyond real time
Published in Nature machine intelligence (01-07-2021)“…Fluorescent genetically encoded calcium indicators and two-photon microscopy help understand brain function by generating large-scale in vivo recordings in…”
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18
Long-term optical brain imaging in live adult fruit flies
Published in Nature communications (28-02-2018)“…Time-lapse in vivo microscopy studies of cellular morphology and physiology are crucial toward understanding brain function but have been infeasible in the…”
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19
Nanobeam photonic crystal cavity quantum dot laser
Published in Optics express (26-04-2010)“…The lasing behavior of one dimensional GaAs nanobeam cavities with embedded InAs quantum dots is studied at room temperature. Lasing is observed throughout the…”
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20
Imaging neural spiking in brain tissue using FRET-opsin protein voltage sensors
Published in Nature communications (22-04-2014)Get full text
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