Search Results - "Yip, Ai Kia"

Cellular Response to Substrate Rigidity Is Governed by Either Stress or Strain by Yip, Ai Kia, Iwasaki, Katsuhiko, Ursekar, Chaitanya, Machiyama, Hiroaki, Saxena, Mayur, Chen, Huiling, Harada, Ichiro, Chiam, Keng-Hwee, Sawada, Yasuhiro

“…Cells sense the rigidity of their substrate; however, little is known about the physical variables that determine their response to this rigidity. Here, we…”
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Epithelial Monolayers Coalesce on a Viscoelastic Substrate through Redistribution of Vinculin by Zheng, Ji Yun, Han, Siew Ping, Chiu, Yi-Jen, Yip, Ai Kia, Boichat, Nicolas, Zhu, Shi Wen, Zhong, Jun, Matsudaira, Paul

“…The mechanical properties of the microenvironment play a large role in influencing cellular behavior. In particular, the tradeoff between substrate viscosity…”
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p53-mediated activation of the mitochondrial protease HtrA2/Omi prevents cell invasion by Yamauchi, Shota, Hou, Yan Yan, Guo, Alvin Kunyao, Hirata, Hiroaki, Nakajima, Wataru, Yip, Ai Kia, Yu, Cheng-han, Harada, Ichiro, Chiam, Keng-Hwee, Sawada, Yasuhiro, Tanaka, Nobuyuki, Kawauchi, Keiko

“…Oncogenic Ras induces cell transformation and promotes an invasive phenotype. The tumor suppressor p53 has a suppressive role in Ras-driven invasion. However,…”
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The role of cell-matrix adhesion and cell migration in breast tumor growth and progression by Chong, Lor Huai, Yip, Ai Kia, Farm, Hui Jia, Mahmoud, Lamees N, Zeng, Yukai, Chiam, Keng-Hwee

“…During breast cancer progression, there is typically increased collagen deposition resulting in elevated extracellular matrix rigidity. This results in changes…”
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Zyxin regulates embryonic stem cell fate by modulating mechanical and biochemical signaling interface by Zhang, Songjing, Chong, Lor Huai, Woon, Jessie Yong Xing, Chua, Theng Xuan, Cheruba, Elsie, Yip, Ai Kia, Li, Hoi-Yeung, Chiam, Keng-Hwee, Koh, Cheng-Gee

“…Biochemical signaling and mechano-transduction are both critical in regulating stem cell fate. How crosstalk between mechanical and biochemical cues influences…”
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MEKK1-dependent phosphorylation of calponin-3 tunes cell contractility by Hirata, Hiroaki, Ku, Wei-Chi, Yip, Ai Kia, Ursekar, Chaitanya Prashant, Kawauchi, Keiko, Roy, Amrita, Guo, Alvin Kunyao, Vedula, Sri Ram Krishna, Harada, Ichiro, Chiam, Keng-Hwee, Ishihama, Yasushi, Lim, Chwee Teck, Sawada, Yasuhiro, Sokabe, Masahiro

“…MEKK1 (also known as MAP3K1), which plays a major role in MAPK signaling, has been implicated in mechanical processes in cells, such as migration. Here, we…”
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Zyxin Is Involved in Fibroblast Rigidity Sensing and Durotaxis by Yip, Ai Kia, Zhang, Songjing, Chong, Lor Huai, Cheruba, Elsie, Woon, Jessie Yong Xing, Chua, Theng Xuan, Goh, Corinna Jie Hui, Yang, Haibo, Tay, Chor Yong, Koh, Cheng-Gee, Chiam, Keng-Hwee

“…Focal adhesions (FAs) are specialized structures that enable cells to sense their extracellular matrix rigidity and transmit these signals to the interior of…”
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A chemotaxis model to explain WHIM neutrophil accumulation in the bone marrow of WHIM mouse model by Yip, Ai Kia, Balachander, Akhila, Tan, Leonard D.L., Liong, Ka Hang, Tan, Rui Zhen, Balabanian, Karl, Bachelerie, Francoise, Ng, Lai Guan, Chiam, Keng-Hwee

“…Neutrophils are essential immune cells that defend the host against pathogenic microbial agents. Neutrophils are produced in the bone marrow and are retained…”
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Intercellular Force Transmission in Wound Closure by Yip, Ai Kia, Chiam, Keng-Hwee

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Cell-Cell Adhesion and Cortical Actin Bending Govern Cell Elongation on Negatively Curved Substrates by Yip, Ai Kia, Huang, Pei, Chiam, Keng-Hwee

“…Physiologically, cells experience and respond to a variety of mechanical stimuli such as rigidity and topography of the extracellular matrix. However, little…”
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Anisotropic traction stresses and focal adhesion polarization mediates topography-induced cell elongation by Yip, Ai Kia, Nguyen, Anh Tuan, Rizwan, Muhammad, Wong, Sum Thai, Chiam, Keng-Hwee, Yim, Evelyn K.F.

“…Cell elongation and differentiation has been shown to be modulated by topographical cues provided by grating substratum. However, little is known about the…”
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Traction stress analysis and modeling reveal that amoeboid migration in confined spaces is accompanied by expansive forces and requires the structural integrity of the membrane-cortex interactions by Yip, Ai Kia, Chiam, Keng-Hwee, Matsudaira, Paul

“…Leukocytes and tumor cells migrate via rapid shape changes in an amoeboid-like manner, distinct from mesenchymal cells such as fibroblasts. However, the…”
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Traction stress analysis and modeling reveal that amoeboid migration in confined spaces is accompanied by expansive forces and requires the structural integrity of the membrane-cortex interactionsElectronic supplementary information (ESI) available. See DOI: 10.1039/c4ib00245h by Yip, Ai Kia, Chiam, Keng-Hwee, Matsudaira, Paul

“…Leukocytes and tumor cells migrate via rapid shape changes in an amoeboid-like manner, distinct from mesenchymal cells such as fibroblasts. However, the…”
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Loss of p53 Enhances NF-κB-Dependent Lamellipodia Formation by Guo, Alvin Kunyao, Hou, Yanyan, Hirata, Hiroaki, Yamauchi, Shota, Yip, Ai Kia, Chiam, Keng-Hwee, Tanaka, Nobuyuki, Sawada, Yasuhiro, Kawauchi, Keiko

“…Tumor suppressor p53 prevents tumorigenesis and tumor growth by suppressing the activation of several transcription factors, including nuclear factor‐κB…”
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A chemotaxis model to explain WHIM neutrophil accumulation in the bone marrow

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A three-dimensional random network model of the cytoskeleton and its role in mechanotransduction and nucleus deformation by Zeng, Yukai, Yip, Ai Kia, Teo, Soo-Kng, Chiam, K.-H.

“…We have developed a three-dimensional random network model of the intracellular actin cytoskeleton and have used it to study the role of the cytoskeleton in…”
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Loss of p53 Enhances NF-[kappa]B-Dependent Lamellipodia Formation by Guo, Alvin Kunyao, Hou, Yanyan, Hirata, Hiroaki, Yamauchi, Shota, Yip, Ai Kia, Chiam, Keng-Hwee, Tanaka, Nobuyuki, Sawada, Yasuhiro, Kawauchi, Keiko

“…Tumor suppressor p53 prevents tumorigenesis and tumor growth by suppressing the activation of several transcription factors, including nuclear factor-[kappa]B…”
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Loss of p53 Enhances NF-κB-Dependent Lamellipodia Formation: NF-κB REGULATES LAMELLIPODIA FORMATION by Guo, Alvin Kunyao, Hou, Yanyan, Hirata, Hiroaki, Yamauchi, Shota, Yip, Ai Kia, Chiam, Keng-Hwee, Tanaka, Nobuyuki, Sawada, Yasuhiro, Kawauchi, Keiko

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