Search Results - "Yingling, J"

18 Drug Discovery and Development - a Changing Paradigm? by Yingling, J

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Activated type I TGFβ receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression by MURAOKA-COOK, R. S, SHIN, I, YI, J. Y, EASTERLY, E, BARCELLOS-HOFF, M. H, YINGLING, J. M, ZENT, R, ARTEAGA, C. L

“…We have examined the effects of transforming growth factor-beta (TGFβ) signaling on mammary epithelial cell survival. Transgenic mice expressing an active…”
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UPDATED U3SI2 thermal creep model and sensitivity analysis of the U3SI2-SIC accident tolerant FUEL by Yingling, J.A., Gamble, K.A., Roberts, Elwyn, Freeman, R. Austin, Knight, Travis W.

“…•Thermal creep of U3Si2 is a minor factor in the thermomechanical performance of U3Si2-SiC fuels.•Low relative thermal conductivity of SiC causes poor…”
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Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein by Yingling, Jonathan M., Datto, Michael B., Wong, Carolyn, Frederick, Joshua P., Liberati, Nicole T., Wang, Xiao-Fan

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Antagonist-stimulated internalization of the G protein-coupled cholecystokinin receptor by Roettger, B F, Ghanekar, D, Rao, R, Toledo, C, Yingling, J, Pinon, D, Miller, L J

“…Receptor-mediated endocytosis has been observed after agonist occupation of several G protein-coupled receptors, which contributes to the desensitization…”
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Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development by Weaver, M, Yingling, J M, Dunn, N R, Bellusci, S, Hogan, B L

“…In the mature mouse lung, the proximal-distal (P-D) axis is delineated by two distinct epithelial subpopulations: the proximal bronchiolar epithelium and the…”
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Mammalian Dwarfins are Phosphorylated in Response to Transforming Growth Factor β and are Implicated in Control of Cell Growth by Yingling, Jonathan M., Das, Pradeep, Savage, Cathy, Zhang, Ming, Padgett, Richard W., Wang, Xiao-Fan

“…The dwarfin protein family has been genetically implicated in transforming growth factor β (TGF-β )-like signaling pathways in Drosophila and Caenorhabditis…”
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Development and validation of a phosphorylated SMAD ex vivo stimulation assay by Farrington, D. L., Yingling, J. M., Fill, J. A., Yan, L., Qian, Y-W., Shou, J., Wang, X., Ehsani, M. E., Cleverly, A. L., Daly, T. M., Lahn, M., Konrad, R. J., Ray, C. A.

“…Abstract Assessing the pharmacodynamics (PD) of a potential therapeutic through the use of a downstream biomarker is essential. This is traditionally performed…”
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A 16 nm All-Digital Auto-Calibrating Adaptive Clock Distribution for Supply Voltage Droop Tolerance Across a Wide Operating Range by Bowman, Keith A., Raina, Sarthak, Bridges, J. Todd, Yingling, Daniel J., Nguyen, Hoan H., Appel, Brad R., Kolla, Yesh N., Jihoon Jeong, Atallah, Francois I., Hansquine, David W.

“…A 16 nm all-digital auto-calibrating adaptive clock distribution (ACD) enhances processor core performance and energy efficiency by mitigating the adverse…”
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SA nodal parasympathectomy delineates autonomic control of heart rate power spectrum by Randall, D C, Brown, D R, Raisch, R M, Yingling, J D, Randall, W C

“…The purpose of this study was to quantify the relative roles of the canine cardiac parasympathetic and sympathetic nerves in controlling the distribution of…”
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Triazolam and zolpidem: a comparison of their psychomotor, cognitive, and subjective effects in healthy volunteers by Mintzer, M Z, Frey, J M, Yingling, J E, Griffiths, R R

“…The psychomotor/cognitive performance, subject-rated, and observer-rated effects of single oral doses of the benzodiazepine hypnotic triazolam (0.125, 0.25,…”
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Epithelial/mesenchymal interactions and branching morphogenesis of the lung by Hogan, Brigid LM, Yingling, Jonathan M

“…The establishment of branched tubular epithelial structures is critical for the viability of multicellular organisms: the tracheal system in Drosophila and the…”
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The viral oncoprotein E1A blocks transforming growth factor beta-mediated induction of p21/WAF1/Cip1 and p15/INK4B by Datto, Michael B., Hu, Patrick Pei-Chih, Kowalik, Timothy F., Yingling, Jonathan, Wang, Xiao-Fan

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Smad5 induces ventral fates in Xenopus embryo by Suzuki, A, Chang, C, Yingling, J M, Wang, X F, Hemmati-Brivanlou, A

“…The Smad proteins have been implicated in the intracellular signaling of transforming growth factor-beta (TGF-beta) ligands. Here we describe the function of…”
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Dihydropyrrolopyrazole Transforming Growth Factor-β Type I Receptor Kinase Domain Inhibitors:  A Novel Benzimidazole Series with Selectivity versus Transforming Growth Factor-β Type II Receptor Kinase and Mixed Lineage Kinase-7 by Li, Hong-yu, Wang, Yan, Heap, Charles R, King, Chi-Hsin R, Mundla, Sreenivasa R, Voss, Matthew, Clawson, David K, Yan, Lei, Campbell, Robert M, Anderson, Bryan D, Wagner, Jill R, Britt, Karen, Lu, Ku X, McMillen, William T, Yingling, Jonathan M

“…Novel dihydropyrrolopyrazole-substituted benzimidazoles were synthesized and evaluated in vitro as inhibitors of transforming growth factor-β type I receptor…”
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An estrogen receptor positive MCF-7 clone that is resistant to antiestrogens and estradiol by Jiang, S Y, Wolf, D M, Yingling, J M, Chang, C, Jordan, V C

“…The antiestrogen tamoxifen has been successfully used to control estrogen receptor (ER) and progesterone receptor positive breast cancer. However, the…”
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mathrm{UPDATED}$ $\mathrm{U3SI2}$ thermal creep model and sensitivity analysis of the $\mathrm{U3SI2-SIC}$ accident tolerant $\mathrm{FUEL} by Yingling, J. A., Gamble, K. A., Roberts, Elwyn, Freeman, R. Austin, Knight, Travis W.

“…U3Si2 is a candidate accident tolerant fuel (ATF) replacement for UO2. U3Si2’s high uranium density and high thermal conductivity are favorable properties in…”
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Thermodynamic measurements and assessments for LiCl-NaCl-KCl-UCl3 systems by Yingling, J.A., Schorne-Pinto, J., Aziziha, M., Ard, J.C., Mofrad, A.M., Christian, M.S., Dixon, C.M., Besmann, T.M.

“…•DSC measurements of the LiCl-UCl3, NaCl-UCl3, KCl-UCl3, LiCl-NaCl-UCl3, and NaCl-KCl-UCl3 salts.•Thermodynamic assessment of the LiCl-NaCl-KCl-UCl3 salt.•Heat…”
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A Transforming Growth Factor β Type I Receptor That Signals to Activate Gene Expression by Bassing, Craig H., Yingling, Jonathan M., Howe, David J., Wang, Tongwen, He, Wei Wu, Gustafson, Michael L., Shah, Paresh, Donahoe, Patricia K., Wang, Xiao-Fan

“…Transforming growth factor beta (TGF-β) is a multifunctional factor that regulates many aspects of cellular functions. TGF-β signals through a heteromeric…”
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Human cigarette smoking: effects of puff and inhalation parameters on smoke exposure by Zacny, J P, Stitzer, M L, Brown, F J, Yingling, J E, Griffiths, R R

“…This study determined effects of three smoking behavior components: puff volume, inhalation volume and lung exposure duration on biological measures of smoke…”
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