Search Results - "Ying, Qi Long"

STAT3 Phosphorylation at Tyrosine 705 and Serine 727 Differentially Regulates Mouse ESC Fates by Huang, Guanyi, Yan, Hexin, Ye, Shoudong, Tong, Chang, Ying, Qi‐Long

“…STAT3 can be transcriptionally activated by phosphorylation of its tyrosine 705 or serine 727 residue. In mouse embryonic stem cells (mESCs), leukemia…”
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Molecular basis of embryonic stem cell self-renewal: from signaling pathways to pluripotency network by Huang, Guanyi, Ye, Shoudong, Zhou, Xingliang, Liu, Dahai, Ying, Qi-Long

“…Embryonic stem cells (ESCs) can be maintained in culture indefinitely while retaining the capacity to generate any type of cell in the body, and therefore not…”
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The ground state of embryonic stem cell self-renewal by Woodgett, James, Batlle-Morera, Laura, Cohen, Philip, Doble, Bradley, Wray, Jason, Nichols, Jennifer, Ying, Qi-Long, Smith, Austin

“…In the three decades since pluripotent mouse embryonic stem (ES) cells were first described they have been derived and maintained by using various empirical…”
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Gbx2, a LIF/Stat3 target, promotes reprogramming to and retention of the pluripotent ground state by Tai, Chih-I, Ying, Qi-Long

“…Activation of signal transducer and activator of transcription 3 (Stat3) by leukemia inhibitory factor (LIF) maintains mouse embryonic stem cell (mESC)…”
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Myeloid Notch1 deficiency activates the RhoA/ROCK pathway and aggravates hepatocellular damage in mouse ischemic livers by Lu, Ling, Yue, Shi, Jiang, Longfeng, Li, Changyong, Zhu, Qiang, Ke, Michael, Lu, Hao, Wang, Xuehao, Busuttil, Ronald W., Ying, Qi‐Long, Kupiec‐Weglinski, Jerzy W., Ke, Bibo

“…Notch signaling plays an emerging role in the regulation of immune cell development and function during inflammatory response. Activation of the ras homolog…”
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Production of p53 gene knockout rats by homologous recombination in embryonic stem cells by Ying, Qi-Long, Tong, Chang, Li, Ping, Wu, Nancy L, Yan, Youzhen

“…The use of homologous recombination to modify genes in embryonic stem (ES) cells provides a powerful means to elucidate gene function and create disease…”
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The myeloid heat shock transcription factor 1/β‐catenin axis regulates NLR family, pyrin domain‐containing 3 inflammasome activation in mouse liver ischemia/reperfusion injury by Yue, Shi, Zhu, Jianjun, Zhang, Ming, Li, Changyong, Zhou, Xingliang, Zhou, Min, Ke, Michael, Busuttil, Ronald W., Ying, Qi‐Long, Kupiec‐Weglinski, Jerzy W., Xia, Qiang, Ke, Bibo

“…Heat shock transcription factor 1 (HSF1) has been implicated in the differential regulation of cell stress and disease states. β‐catenin activation is…”
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Capture of Authentic Embryonic Stem Cells from Rat Blastocysts by Buehr, Mia, Meek, Stephen, Blair, Kate, Yang, Jian, Ure, Janice, Silva, Jose, McLay, Renee, Hall, John, Ying, Qi-Long, Smith, Austin

“…Embryonic stem (ES) cells have been available from inbred mice since 1981 but have not been validated for other rodents. Failure to establish ES cells from a…”
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The Art of Capturing Pluripotency: Creating the Right Culture by Ying, Qi-Long, Smith, Austin

“…Embryonic stem cells (ESCs) are a unique tool for genetic perturbation of mammalian cellular and organismal processes additionally in humans offer…”
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TFCP2L1 represses multiple lineage commitment of mouse embryonic stem cells through MTA1 and LEF1 by Liu, Kuisheng, Zhang, Yan, Liu, Dahai, Ying, Qi-Long, Ye, Shoudong

“…TFCP2L1 is a transcription factor that is crucial for self-renewal of mouse embryonic stem cells (mESCs). How TFCP2L1 maintains the pluripotent state of mESCs,…”
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Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture by Smith, Austin, Ying, Qi-Long, Stavridis, Marios, Griffiths, Dean, Li, Meng

“…Mouse embryonic stem (ES) cells are competent for production of all fetal and adult cell types. However, the utility of ES cells as a developmental model or as…”
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Sp5 induces the expression of Nanog to maintain mouse embryonic stem cell self-renewal by Tang, Ling, Wang, Manman, Liu, Dahai, Gong, Mengting, Ying, Qi-Long, Ye, Shoudong

“…Activation of signal transducer and activator of transcription 3 (STAT3) by leukemia inhibitory factor (LIF) maintains mouse embryonic stem cell (mESC)…”
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Optimization of Cas9 RNA sequence to reduce its unexpected effects as a microRNA sponge by Jiang, Junfeng, Zeng, Tao, Zhang, Li, Fan, Xingfei, Jin, Qishu, Ni, Haitao, Ye, Yusheng, Cheng, Lipeng, Li, Li, Wang, Liujun, Xu, Sha, Yang, Yu, Gu, Juan, Guo, Bing, Wang, Lei, Li, Xin, Qin, Yingyi, Li, Jiaxi, Wang, Jinjiang, Chen, Xi, Wu, Minjuan, Ying, Qi-long, Qin, Xingjun, Wang, Yefei, Wang, Yue

“…Section Highlights Cas9 RNA functions as a miRNA sponge. Let-7 is the dominant regulated miRNA by Cas9 RNA. RNA sequence optimization of Cas9 by synonymous…”
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Niche-independent symmetrical self-renewal of a mammalian tissue stem cell by Conti, Luciano, Pollard, Steven M, Gorba, Thorsten, Reitano, Erika, Toselli, Mauro, Biella, Gerardo, Sun, Yirui, Sanzone, Sveva, Ying, Qi-Long, Cattaneo, Elena, Smith, Austin

“…Pluripotent mouse embryonic stem (ES) cells multiply in simple monoculture by symmetrical divisions. In vivo, however, stem cells are generally thought to…”
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Klf2 and Tfcp2l1, Two Wnt/β-Catenin Targets, Act Synergistically to Induce and Maintain Naive Pluripotency by Qiu, Dongbo, Ye, Shoudong, Ruiz, Bryan, Zhou, Xingliang, Liu, Dahai, Zhang, Qi, Ying, Qi-Long

“…Activation of Wnt/β-catenin signaling can induce both self-renewal and differentiation in naive pluripotent embryonic stem cells (ESCs). To gain insights into…”
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Blockade of Notch signaling promotes acetaminophen-induced liver injury by Jiang, Longfeng, Ke, Michael, Yue, Shi, Xiao, Wen, Yan, Youde, Deng, Xiaozhao, Ying, Qi-Long, Li, Jun, Ke, Bibo

“…Liver injury after experimental acetaminophen treatment is mediated both by direct hepatocyte injury through a P450-generated toxic metabolite and indirectly…”
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Changing potency by spontaneous fusion by Smith, Austin G, Ying, Qi-Long, Nichols, Jennifer, Evans, Edward P

“…Recent reports have suggested that mammalian stem cells residing in one tissue may have the capacity to produce differentiated cell types for other tissues and…”
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Embryonic stem cell self-renewal pathways converge on the transcription factor Tfcp2l1 by Ye, Shoudong, Li, Ping, Tong, Chang, Ying, Qi-Long

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Induction of site-specific chromosomal translocations in embryonic stem cells by CRISPR/Cas9 by Jiang, Junfeng, Zhang, Li, Zhou, Xingliang, Chen, Xi, Huang, Guanyi, Li, Fengsheng, Wang, Ruizhe, Wu, Nancy, Yan, Youzhen, Tong, Chang, Srivastava, Sankalp, Wang, Yue, Liu, Houqi, Ying, Qi-Long

“…Chromosomal translocation is the most common form of chromosomal abnormality and is often associated with congenital genetic disorders, infertility and…”
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p53 promotes inflammation-associated hepatocarcinogenesis by inducing HMGB1 release by Yan, He-Xin, Wu, Hong-Ping, Zhang, Hui-Lu, Ashton, Charles, Tong, Chang, Wu, Han, Qian, Qi-Jun, Wang, Hong-Yang, Ying, Qi-Long

“…Background & Aims Hepatocellular carcinoma (HCC) develops in response to chronic hepatic injury. Although induced cell death is regarded as the major component…”
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