Search Results - "Ying, Guoguang"

CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer by Zhang, Haiyang, Deng, Ting, Liu, Rui, Ning, Tao, Yang, Haiou, Liu, Dongying, Zhang, Qiumo, Lin, Dan, Ge, Shaohua, Bai, Ming, Wang, Xinyi, Zhang, Le, Li, Hongli, Yang, Yuchong, Ji, Zhi, Wang, Hailong, Ying, Guoguang, Ba, Yi

“…Ferroptosis is a novel mode of non-apoptotic cell death induced by build-up of toxic lipid peroxides (lipid-ROS) in an iron dependent manner. Cancer-associated…”
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Glutathione reductase mediates drug resistance in glioblastoma cells by regulating redox homeostasis by Zhu, Zhongling, Du, Shuangshuang, Du, Yibo, Ren, Jing, Ying, Guoguang, Yan, Zhao

“…Glutathione (GSH) and GSH‐related enzymes constitute the most important defense system that protects cells from free radical, radiotherapy, and chemotherapy…”
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Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis by Zhang, Haiyang, Deng, Ting, Liu, Rui, Bai, Ming, Zhou, Likun, Wang, Xia, Li, Shuang, Wang, Xinyi, Yang, Haiou, Li, Jialu, Ning, Tao, Huang, Dingzhi, Li, Hongli, Zhang, Le, Ying, Guoguang, Ba, Yi

“…The metastatic organotropism has been one of the cancer’s greatest mysteries since the ‘seed and soil’ hypothesis. Although the role of EGFR in cancer cells is…”
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Exosome‐delivered circRNA promotes glycolysis to induce chemoresistance through the miR‐122‐PKM2 axis in colorectal cancer by Wang, Xinyi, Zhang, Haiyang, Yang, Haiou, Bai, Ming, Ning, Tao, Deng, Ting, Liu, Rui, Fan, Qian, Zhu, Kegan, Li, Jialu, Zhan, Yang, Ying, Guoguang, Ba, Yi

“…Malignant tumors, including colorectal cancer (CRC), usually rely on ATP generation through aerobic glycolysis for both rapid growth and chemotherapy…”
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Exosomes serve as nanoparticles to suppress tumor growth and angiogenesis in gastric cancer by delivering hepatocyte growth factor siRNA by Zhang, Haiyang, Wang, Yi, Bai, Ming, Wang, Junyi, Zhu, Kegan, Liu, Rui, Ge, Shaohua, Li, JiaLu, Ning, Tao, Deng, Ting, Fan, Qian, Li, Hongli, Sun, Wu, Ying, Guoguang, Ba, Yi

“…Exosomes derived from cells have been found to mediate signal transduction between cells and to act as efficient carriers to deliver drugs and small RNA…”
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TM4SF1 promotes EMT and cancer stemness via the Wnt/β-catenin/SOX2 pathway in colorectal cancer by Tang, Qiang, Chen, Jinhuang, Di, Ziyang, Yuan, Wenzheng, Zhou, Zili, Liu, Zhengyi, Han, Shengbo, Liu, Yanwei, Ying, Guoguang, Shu, Xiaogang, Di, Maojun

“…Transmembrane 4 L six family member 1 (TM4SF1) is upregulated in several epithelial cancers and is closely associated with poor prognosis. However, the role of…”
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Gastric cancer derived exosomes mediate the delivery of circRNA to promote angiogenesis by targeting miR-29a/VEGF axis in endothelial cells by Li, Shuang, Li, Jialu, Zhang, Haiyang, Zhang, Yan, Wang, Xinyi, Yang, Haiou, Zhou, Zhengyang, Hao, Xishan, Ying, Guoguang, Ba, Yi

“…Accumulating evidence has been found that circular RNA (circRNA) plays a critical role in the initiation and development of various diseases by modulating gene…”
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Hypoxia induced exosomal circRNA promotes metastasis of Colorectal Cancer via targeting GEF-H1/RhoA axis by Yang, Haiou, Zhang, Haiyang, Yang, Yuchong, Wang, Xinyi, Deng, Ting, Liu, Rui, Ning, Tao, Bai, Ming, Li, Hongli, Zhu, Kegan, Li, Jialu, Fan, Qian, Ying, Guoguang, Ba, Yi

“…Hypoxia is one of the important properties of solid tumor. However, oxygen supply within tumors is generally heterogeneous according to the distance from the…”
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iRGD‐modified exosomes effectively deliver CPT1A siRNA to colon cancer cells, reversing oxaliplatin resistance by regulating fatty acid oxidation by Lin, Dan, Zhang, Haiyang, Liu, Rui, Deng, Ting, Ning, Tao, Bai, Ming, Yang, Yuchong, Zhu, Kegan, Wang, Junyi, Duan, Jingjing, Ge, Shaohua, Sun, Bei, Ying, Guoguang, Ba, Yi

“…Fatty acid oxidation (FAO) plays a vital role in drug resistance in cancer cells. Carnitine palmitoyltransferase 1A (CPT1A), a key enzyme of FAO, is widely…”
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Potential of electron transfer and its application in dictating routes of biochemical processes associated with metabolic reprogramming by Yang, Ronghui, Ying, Guoguang, Li, Binghui

“…Metabolic reprogramming, such as abnormal utilization of glucose, addiction to glutamine, and increased de-novo lipid synthesis, extensively occurs in…”
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Visualization of caspase-3-like activity in cells using a genetically encoded fluorescent biosensor activated by protein cleavage by Zhang, Jiao, Wang, Xin, Cui, Wenjing, Wang, Wenwen, Zhang, Huamei, Liu, Lu, Zhang, Zicheng, Li, Zheng, Ying, Guoguang, Zhang, Ning, Li, Binghui

“…Cytosolic caspase-3-like proteases, such as caspase-3 and caspase-7, have a central role in mediating the progress of apoptosis. Here to conveniently monitor…”
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Cell-derived microvesicles mediate the delivery of miR-29a/c to suppress angiogenesis in gastric carcinoma by Zhang, Haiyang, Bai, Ming, Deng, Ting, Liu, Rui, Wang, Xia, Qu, Yanjun, Duan, Jingjing, Zhang, Le, Ning, Tao, Ge, Shaohua, Li, Hongli, Zhou, Likun, Liu, Yuchen, Ying, Guoguang, Huang, Dingzhi, Ba, Yi

“…Highlights • Suppressed expression of miR-29a/c leads to the high levels of VEGF in the gastric tumor microenvironment. • miR-29a/c regulates VEGF expression…”
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MicroRNA‐155 promotes gastric cancer growth and invasion by negatively regulating transforming growth factor‐β receptor 2 by Qu, Yajing, Zhang, Haiyang, Sun, Wu, Han, Yueting, Li, Shuang, Qu, Yanjun, Ying, Guoguang, Ba, Yi

“…Gastric cancer (GC) is one of the most common malignancies worldwide and has high morbidity and mortality rates. It is essential to elucidate the molecular…”
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Cell-derived Exosomes as Promising Carriers for Drug Delivery and Targeted Therapy by Wang, Xinyi, Zhang, Haiyang, Yang, Haiou, Bai, Ming, Ning, Tao, Li, Shuang, Li, Jialu, Deng, Ting, Ying, Guoguang, Ba, Yi

“…Exosomes are small vesicles that are secreted by various types of cells, known to mediate signal transduction between cells. During recent years, novel…”
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Fluzoparib increases radiation sensitivity of non-small cell lung cancer (NSCLC) cells without BRCA1/2 mutation, a novel PARP1 inhibitor undergoing clinical trials by Luo, Jing, Dai, Xinchi, Hu, Hua, Chen, Jie, Zhao, Lujun, Yang, Changyong, Sun, Jifeng, Zhang, Lianmin, Wang, Qian, Xu, Shilei, Xu, Yue, Liu, Ningbo, Ying, Guoguang, Wang, Ping

“…Propose Poly (ADP-ribose) polymerase 1 inhibitors were originally investigated as anti-cancer therapeutics with BRCA1/2 genes mutation. Here, we investigate…”
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Discovery and Validation of a Novel Metastasis-Related lncRNA Prognostic Signature for Colorectal Cancer by Tang, Qiang, Hu, Xin, Guo, Qiong, Shi, Yueyue, Liu, Liming, Ying, Guoguang

“…Cancer metastasis-related chemoresistance and tumour progression are the leading causes of death among CRC patients. Therefore, it is urgent to identify…”
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Metformin Potentiates the Effects of Anlotinib in NSCLC via AMPK/mTOR and ROS-Mediated Signaling Pathways by Zhu, Zhongling, Jiang, Teng, Suo, Huirong, Xu, Shan, Zhang, Cai, Ying, Guoguang, Yan, Zhao

“…Anlotinib is a novel multi-targeted tyrosine kinase inhibitor with activity against soft tissue sarcoma, small cell lung cancer, and non-small cell lung cancer…”
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Exosome miR-155 Derived from Gastric Carcinoma Promotes Angiogenesis by Targeting the c-MYB/VEGF Axis of Endothelial Cells by Deng, Ting, Zhang, Haiyang, Yang, Haiou, Wang, Huiya, Bai, Ming, Sun, Wu, Wang, Xinyi, Si, Yiran, Ning, Tao, Zhang, Le, Li, Hongli, Ge, Shaohua, Liu, Rui, Lin, Dan, Li, Shuang, Ying, Guoguang, Ba, Yi

“…Exosomes, membranous nanovesicles, naturally carry proteins, mRNAs, and microRNAs (miRNAs) and play important roles in tumor pathogenesis. Here we showed that…”
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Polo-like kinase 4 mediates epithelial–mesenchymal transition in neuroblastoma via PI3K/Akt signaling pathway by Tian, Xiangdong, Zhou, Dejun, Chen, Lu, Tian, Yao, Zhong, Benfu, Cao, Yanna, Dong, Qiuping, Zhou, Meng, Yan, Jie, Wang, Yalei, Qiu, Yanli, Zhang, Lianmin, Li, Zhongyuan, Wang, Huijuan, Wang, Daowei, Ying, Guoguang, Zhao, Qiang

“…Neuroblastoma (NB) is the most common malignant tumor in infancy and most common extracranial solid tumor in childhood. With the improvement of diagnosis and…”
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Author Correction: Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis by Zhang, Haiyang, Deng, Ting, Liu, Rui, Bai, Ming, Zhou, Likun, Wang, Xia, Li, Shuang, Wang, Xinyi, Yang, Haiou, Li, Jialu, Ning, Tao, Huang, Dingzhi, Li, Hongli, Zhang, Le, Ying, Guoguang, Ba, Yi

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