Search Results - "Ying, Baoling"

An intranasal vaccine durably protects against SARS-CoV-2 variants in mice by Hassan, Ahmed O., Shrihari, Swathi, Gorman, Matthew J., Ying, Baoling, Yaun, Dansu, Raju, Saravanan, Chen, Rita E., Dmitriev, Igor P., Kashentseva, Elena, Adams, Lucas J., Mann, Colin, Davis-Gardner, Meredith E., Suthar, Mehul S., Shi, Pei-Yong, Saphire, Erica Ollmann, Fremont, Daved H., Curiel, David T., Alter, Galit, Diamond, Michael S.

“…SARS-CoV-2 variants that attenuate antibody neutralization could jeopardize vaccine efficacy. We recently reported the protective activity of an intranasally…”
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Drug development against human adenoviruses and its advancement by Syrian hamster models by Wold, William S M, Tollefson, Ann E, Ying, Baoling, Spencer, Jacqueline F, Toth, Karoly

“…The symptoms of human adenovirus infections are generally mild and self-limiting. However, these infections have been gaining importance in recent years…”
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Pharmacological activation of STING blocks SARS-CoV-2 infection by Li, Minghua, Ferretti, Max, Ying, Baoling, Descamps, Hélène, Lee, Emily, Dittmar, Mark, Lee, Jae Seung, Whig, Kanupriya, Kamalia, Brinda, Dohnalová, Lenka, Uhr, Giulia, Zarkoob, Hoda, Chen, Yu-Chi, Ramage, Holly, Ferrer, Marc, Lynch, Kristen, Schultz, David C., Thaiss, Christoph A., Diamond, Michael S., Cherry, Sara

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic, resulting millions of infections and deaths with few effective…”
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Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strains by Ying, Baoling, Whitener, Bradley, VanBlargan, Laura A, Hassan, Ahmed O, Shrihari, Swathi, Liang, Chieh-Yu, Karl, Courtney E, Mackin, Samantha, Chen, Rita E, Kafai, Natasha M, Wilks, Samuel H, Smith, Derek J, Carreño, Juan Manuel, Singh, Gagandeep, Krammer, Florian, Carfi, Andrea, Elbashir, Sayda M, Edwards, Darin K, Thackray, Larissa B, Diamond, Michael S

“…Although mRNA vaccines encoding the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prevent COVID-19, the emergence of new viral…”
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Longitudinal Monitoring of the Effects of Anti-Adenoviral Treatment Regimens in a Permissive In Vivo Model by Tollefson, Ann E, Cline-Smith, Anna, Spencer, Jacqueline F, Ying, Baoling, Reyna, Dawn M, Lipka, Elke, James, Scott H, Toth, Karoly

“…Adenovirus infections of immunocompromised patients can cause life-threatening disseminated disease. While there are presently no drugs specifically approved…”
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STAT2 Knockout Syrian Hamsters Support Enhanced Replication and Pathogenicity of Human Adenovirus, Revealing an Important Role of Type I Interferon Response in Viral Control by Toth, Karoly, Lee, Sang R, Ying, Baoling, Spencer, Jacqueline F, Tollefson, Ann E, Sagartz, John E, Kong, Il-Keun, Wang, Zhongde, Wold, William S M

“…Human adenoviruses have been studied extensively in cell culture and have been a model for studies in molecular, cellular, and medical biology. However, much…”
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Ganciclovir inhibits human adenovirus replication and pathogenicity in permissive immunosuppressed Syrian hamsters by Ying, Baoling, Tollefson, Ann E, Spencer, Jacqueline F, Balakrishnan, Lata, Dewhurst, Stephen, Capella, Cristina, Buller, R Mark L, Toth, Karoly, Wold, William S M

“…Adenovirus infections of immunocompromised patients can develop into deadly multiorgan or systemic disease. The virus is especially threatening for pediatric…”
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Cidofovir and brincidofovir reduce the pathology caused by systemic infection with human type 5 adenovirus in immunosuppressed Syrian hamsters, while ribavirin is largely ineffective in this model by Tollefson, Ann E., Spencer, Jacqueline F., Ying, Baoling, Buller, R. Mark L., Wold, William S.M., Toth, Karoly

“…•A permissive animal model was used to test the efficacy of three drugs against disseminated human adenovirus infection.•These three drugs are used in the…”
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Characterization of an N-Terminal Non-Core Domain of RAG1 Gene Disrupted Syrian Hamster Model Generated by CRISPR Cas9 by Miao, Jinxin, Ying, Baoling, Li, Rong, Tollefson, Ann E, Spencer, Jacqueline F, Wold, William S M, Song, Seok-Hwan, Kong, Il-Keun, Toth, Karoly, Wang, Yaohe, Wang, Zhongde

“…The accumulating evidence demonstrates that Syrian hamsters have advantages as models for various diseases. To develop a Syrian hamster ( ) model of human…”
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Generation and characterization of an IL2RG knockout Syrian hamster model for XSCID and HAdV-C6 infection in immunocompromised patients by Li, Rong, Ying, Baoling, Liu, Yanan, Spencer, Jacqueline F, Miao, Jinxin, Tollefson, Ann E, Brien, James D, Wang, Yaohe, Wold, William S M, Wang, Zhongde, Toth, Karoly

“…Model animals are indispensable for the study of human diseases, and in general, of complex biological processes. The Syrian hamster is an important model…”
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Anti-adenoviral Artificial MicroRNAs Expressed from AAV9 Vectors Inhibit Human Adenovirus Infection in Immunosuppressed Syrian Hamsters by Schaar, Katrin, Geisler, Anja, Kraus, Milena, Pinkert, Sandra, Pryshliak, Markian, Spencer, Jacqueline F., Tollefson, Ann E., Ying, Baoling, Kurreck, Jens, Wold, William S., Klopfleisch, Robert, Toth, Karoly, Fechner, Henry

“…Infections of immunocompromised patients with human adenoviruses (hAd) can develop into life-threatening conditions, whereas drugs with anti-adenoviral…”
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mRNA-1273 and Ad26.COV2.S vaccines protect against the B.1.621 variant of SARS-CoV-2 by Darling, Tamarand L, Ying, Baoling, Whitener, Bradley, VanBlargan, Laura A, Bricker, Traci L, Liang, Chieh-Yu, Joshi, Astha, Bamunuarachchi, Gayan, Seehra, Kuljeet, Schmitz, Aaron J, Halfmann, Peter J, Kawaoka, Yoshihiro, Elbashir, Sayda M, Edwards, Darin K, Thackray, Larissa B, Diamond, Michael S, Boon, Adrianus C M

“…Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019, viral variants with greater transmissibility or immune-evasion…”
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Correction: STAT2 Knockout Syrian Hamsters Support Enhanced Replication and Pathogenicity of Human Adenovirus, Revealing an Important Role of Type I Interferon Response in Viral Control by Toth, Karoly, Lee, Sang R, Ying, Baoling, Spencer, Jacqueline F, Tollefson, Ann E, Sagartz, John E, Kong, Il-Keun, Wang, Zhongde, Wold, William S M

“…[This corrects the article DOI: 10.1371/journal.ppat.1005084.]…”
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Valganciclovir inhibits human adenovirus replication and pathology in permissive immunosuppressed female and male Syrian hamsters by Toth, Karoly, Ying, Baoling, Tollefson, Ann E, Spencer, Jacqueline F, Balakrishnan, Lata, Sagartz, John E, Buller, Robert Mark L, Wold, William S M

“…Adenovirus infections of immunocompromised pediatric hematopoietic stem cell transplant patients can develop into serious and often deadly multi-organ disease…”
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Identification of a Previously Unrecognized Promoter That Drives Expression of the UXP Transcription Unit in the Human Adenovirus Type 5 Genome by BAOLING YING, TOLLEFSON, Ann E, WOLD, William S. M

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Identification of a New Human Adenovirus Protein Encoded by a Novel Late l-Strand Transcription Unit by TOLLEFSON, Ann E, BAOLING YING, DORONIN, Konstantin, SIDOR, Peter D, WOLD, William S. M

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An oncolytic adenovirus vector combining enhanced cell-to-cell spreading, mediated by the ADP cytolytic protein, with selective replication in cancer cells with deregulated Wnt signaling by TOTH, Karoly, DJEHA, Hakim, BAOLING YING, TOLLEFSON, Ann E, KUPPUSWAMY, Mohan, DORONIN, Konstantin, KRAJCSI, Peter, LIPINSKI, Kai, WRIGHTON, Christopher J, WOLD, William S. M

“…We have constructed a novel oncolytic adenovirus (Ad) vector named VRX-009 that combines enhanced cell spread with tumor-specific replication. Enhanced spread,…”
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Mutations within the ADP (E3-11.6K) Protein Alter Processing and Localization of ADP and the Kinetics of Cell Lysis of Adenovirus-Infected Cells by Tollefson, Ann E, Scaria, Abraham, Ying, Baoling, Wold, William S M

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Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant in mice by Scheaffer, Suzanne M., Lee, Diana, Whitener, Bradley, Ying, Baoling, Wu, Kai, Liang, Chieh-Yu, Jani, Hardik, Martin, Philippa, Amato, Nicholas J., Avena, Laura E., Berrueta, Daniela Montes, Schmidt, Stephen D., O’Dell, Sijy, Nasir, Arshan, Chuang, Gwo-Yu, Stewart-Jones, Guillaume, Koup, Richard A., Doria-Rose, Nicole A., Carfi, Andrea, Elbashir, Sayda M., Thackray, Larissa B., Edwards, Darin K., Diamond, Michael S.

“…The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants in the Omicron lineage has resulted in diminished Coronavirus Disease…”
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In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains by Chen, Rita E., Winkler, Emma S., Case, James Brett, Aziati, Ishmael D., Bricker, Traci L., Joshi, Astha, Darling, Tamarand L., Ying, Baoling, Errico, John M., Shrihari, Swathi, VanBlargan, Laura A., Xie, Xuping, Gilchuk, Pavlo, Zost, Seth J., Droit, Lindsay, Liu, Zhuoming, Stumpf, Spencer, Wang, David, Handley, Scott A., Stine, W. Blaine, Shi, Pei-Yong, Davis-Gardner, Meredith E., Suthar, Mehul S., Knight, Miguel Garcia, Andino, Raul, Chiu, Charles Y., Ellebedy, Ali H., Fremont, Daved H., Whelan, Sean P. J., Crowe, James E., Purcell, Lisa, Corti, Davide, Boon, Adrianus C. M., Diamond, Michael S.

“…Rapidly emerging SARS-CoV-2 variants jeopardize antibody-based countermeasures. Although cell culture experiments have demonstrated a loss of potency of…”
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