Search Results - "Yin, Tyler"

First-in-human phase 1 clinical trial of anti-core 1 O-glycans targeting monoclonal antibody NEO-201 in treatment-refractory solid tumors by Cole, Christopher B, Morelli, Maria Pia, Fantini, Massimo, Miettinen, Markku, Fetsch, Patricia, Peer, Cody, Figg, William D, Yin, Tyler, Houston, Nicole, McCoy, Ann, Lipkowitz, Stanley, Zimmer, Alexandra, Lee, Jung-Min, Pavelova, Miroslava, Villanueva, Erin N, Trewhitt, Kathryn, Solarz, B Brooke, Fergusson, Maria, Mavroukakis, Sharon A, Zaki, Anjum, Tsang, Kwong Y, Arlen, Philip M, Annunziata, Christina M

“…NEO201 is a humanized IgG1 monoclonal antibody (mAb) generated against tumor-associated antigens from patients with colorectal cancer. NEO-201 binds to core 1…”
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Fundamentals of Pharmacogenetics in Personalized, Precision Medicine by Valdes, Roland, PhD, DABCC, Yin, DeLu (Tyler), PhD

“…This article introduces fundamental principles of pharmacogenetics as applied to personalized and precision medicine. Pharmacogenetics establishes…”
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Correction: First-in-human phase 1 clinical trial of anti-core 1 O-glycans targeting monoclonal antibody NEO-201 in treatment-refractory solid tumors by Cole, Christopher B, Morelli, Maria Pia, Fantini, Massimo, Miettinen, Markku, Fetsch, Patricia, Peer, Cody, Figg, William D, Yin, Tyler, Houston, Nicole, McCoy, Ann, Lipkowitz, Stanley, Zimmer, Alexandra, Lee, Jung-Min, Pavelova, Miroslava, Villanueva, Erin N, Trewhitt, Kathryn, Solarz, B Brooke, Fergusson, Maria, Mavroukakis, Sharon A, Zaki, Anjum, Tsang, Kwong Y, Arlen, Philip M, Annunziata, Christina M

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Improved pretreatment of lignocellulosic biomass using enzymatically-generated peracetic acid by Yin, DeLu (Tyler), Jing, Qing, AlDajani, Waleed Wafa, Duncan, Shona, Tschirner, Ulrike, Schilling, Jonathan, Kazlauskas, Romas J.

“…[Display omitted] ► Perhydrolases form peracetic acid from ethyl acetate and hydrogen peroxide. ► Peracetic acid fragments lignin, but does not damage…”
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Structure–function characterization reveals new catalytic diversity in the galactose oxidase and glyoxal oxidase family by Yin, DeLu (Tyler), Urresti, Saioa, Lafond, Mickael, Johnston, Esther M., Derikvand, Fatemeh, Ciano, Luisa, Berrin, Jean-Guy, Henrissat, Bernard, Walton, Paul H., Davies, Gideon J., Brumer, Harry

“…Alcohol oxidases, including carbohydrate oxidases, have a long history of research that has generated fundamental biological understanding and biotechnological…”
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Cellulose-Based Biosensors for Esterase Detection by Derikvand, Fatemeh, Yin, DeLu Tyler, Barrett, Ryan, Brumer, Harry

“…Cellulose has emerged as an attractive substrate for the production of economical, disposable, point-of-care (POC) analytical devices. Development of novel…”
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Revised Molecular Basis of the Promiscuous Carboxylic Acid Perhydrolase Activity in Serine Hydrolases by Yin, DeLu (Tyler), Kazlauskas, Romas J.

“…Several serine hydrolases catalyze a promiscuous reaction: perhydrolysis of carboxylic acids to form peroxycarboxylic acids. The working hypothesis is that…”
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New Structural Motif for Carboxylic Acid Perhydrolases by Yin, DeLu (Tyler), Purpero, Vince M., Fujii, Ryota, Jing, Qing, Kazlauskas, Romas J.

“…Some serine hydrolases also catalyze a promiscuous reaction— reversible perhydrolysis of carboxylic acids to make peroxycarboxylic acids. Five X‐ray crystal…”
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Development and validation of a simple, selective, and sensitive LC-MS/MS assay for the quantification of remdesivir in human plasma by Nguyen, Ryan, Goodell, Jennifer C., Shankarappa, Priya S., Zimmerman, Sara, Yin, Tyler, Peer, Cody J., Figg, William D.

“…•A fully validated HPLC-MS/MS assay for quantifying remdesivir in human plasma.•Rapid one-step solid-phase extraction was applied using an Ostro…”
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Long interspersed nuclear element-1 mobilization as a target in cancer diagnostics, prognostics and therapeutics by Lavasanifar, Afsaneh, Sharp, Cierra N., Korte, Erik A., Yin, Tyler, Hosseinnejad, Keivan, Jortani, Saeed A.

“…Long Interspersed Nuclear Element-1 (LINE-1) are DNAs that compromise 17% of our genome. LINE-1 expression is triggered by environmental stressors and…”
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Checkpoint inhibitor immunotherapy during pregnancy for relapsed–refractory Hodgkin lymphoma by Evens, Andrew M., Brandt, Justin S., Peer, Cody J., Yin, Tyler, Schaar, Dale, Farooq, Faheem, Mozarsky, Brett, Figg, William D., Sharon, Elad

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Discovery of the Long Interspersed Nuclear Element-1 activation product [Open Reading Frame-1 (ORF1) protein] in human blood by Hosseinnejad, Keivan, Yin, Tyler, Gaskins, Jeremy T., Bailen, James L., Jortani, Saeed A.

“…Long Interspersed Nuclear Element 1 is the only autonomous mobile DNA capable of self-propagation, and is an environmental biomarker that is activated upon an…”
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A Multi-Institution Analysis of Relapsed Lymphoma Occurring during Pregnancy Including Pharmacokinetics with Antenatal Checkpoint Inhibitor Therapy by Farooq, Faheem, Cardonick, Elyce, Polushkina, Evgenia, Ahmed, Sairah, Ramakrishnan, Praveen, Olszewski, Adam J., Yasin, Hesham, Hamad, Nada, Lin, Yong, Edmonds, Jennifer, Ciavolino, Laura, Maggen, Charlotte, Fruscio, Robert, Gziri, Mina Mhallem, Steffensen, Karina Dahl, Farooq, Umar, Amant, Frédéric, Sharon, Elad, Yin, Tyler, Figg, William D., Brandt, Justin, Peer, Cody, Vose, Julie M., Evens, Andrew Matthew

“…Introduction: Lymphoma (LYM) diagnosed during pregnancy is an uncommon occurrence. There are significant ethical and management challenges that involve…”
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Quantitation of the next-generation imipridone ONC206 in human plasma by a simple and sensitive UPLC-MS/MS assay for clinical pharmacokinetic application by Goodell, Jennifer C., Zimmerman, Sara M., Peer, Cody J., Prabhu, Varun, Yin, Tyler, Richardson, William J., Azinfar, Arya, Dunn, John A., Mullin, Mark, Theeler, Brett J., Gilbert, Mark, Figg, William D.

“…ONC206 is an imipridone derivative that is being developed clinically as a single agent given orally in a first-in-human trial (NCT04541082). This ongoing…”
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Switching Catalysis from Hydrolysis to Perhydrolysis in Pseudomonas fluorescens Esterase by Yin, De Lu (Tyler), Bernhardt, Peter, Morley, Krista L, Jiang, Yun, Cheeseman, Jeremy D, Purpero, Vincent, Schrag, Joseph D, Kazlauskas, Romas J

“…Many serine hydrolases catalyze perhydrolysis, the reversible formation of peracids from carboxylic acids and hydrogen peroxide. Recently, we showed that a…”
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Lack of Influence by CYP3A4 and CYP3A5 Genotypes on Pain Relief by Hydrocodone in Postoperative Cesarean Section Pain Management by Hosseinnejad, Keivan, Yin, Tyler, Gaskins, Jeremy T, Stauble, M Elaine, Wu, Yanhong, Jannetto, Paul, Langman, Loralie L, Jortani, Saeed A

“…Abstract Background Genetic polymorphisms of cytochrome P450 are contributors to variability in individual response to drugs. Within the P450 family, CYP2D6 is…”
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Ecopoetics and Poetry of Du Fu and Kenneth Rexroth: Immediate Experiences in Society and Nature by Tsui, Tyler Kwing Yin

“…This thesis explores the poetry of Du Fu and Kennerth Rexroth from the perspective of ecopoetics. Often dubbed the Poet Historian or Poet Sage, Du Fu 杜甫…”
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Structure–function characterization reveals new catalytic diversity in the galactose oxidase and glyoxal oxidase family by Yin, Delu (tyler), Urresti, Saioa, Lafond, Mickael, Johnston, Esther M., Derikvand, Fatemeh, Ciano, Luisa, Berrin, Jean-Guy, Henrissat, Bernard, Walton, Paul H., Davies, Gideon J., Brumer, Harry

“…Alcohol oxidases, including carbohydrate oxidases, have a long history of research that has generated fundamental biological understanding and biotechnological…”
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Molecular Basis of Chiral Acid Recognition by Candida rugosa Lipase: X-Ray Structure of Transition State Analog and Modeling of the Hydrolysis of Methyl 2-Methoxy-2-phenylacetate by Colton, Ian J., Yin, DeLu (Tyler), Grochulski, Pawel, Kazlauskas, Romas J.

“…Lipase from Candida rugosa shows high enantioselectivity toward α‐substituted chiral acids such as 2‐arylpropionic acids. To understand how Candida rugosa…”
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Enzyme catalyzed perhydrolysis, molecular basis and application by Yin, Delu Tyler

“…Enzyme catalyzed perhydrolysis converts a carboxylic acid or ester to a peracid. In the former reaction, the amount of peracid generated is thermodynamically…”
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