Search Results - "Yin, Shuming"

Dual base editor catalyzes both cytosine and adenine base conversions in human cells by Zhang, Xiaohui, Zhu, Biyun, Chen, Liang, Xie, Ling, Yu, Weishi, Wang, Ying, Li, Linxi, Yin, Shuming, Yang, Lei, Hu, Handan, Han, Honghui, Li, Yongmei, Wang, Liren, Chen, Geng, Ma, Xueyun, Geng, Hongquan, Huang, Wanfeng, Pang, Xiufeng, Yang, Zuozhen, Wu, Yuxuan, Siwko, Stefan, Kurita, Ryo, Nakamura, Yukio, Yang, Li, Liu, Mingyao, Li, Dali

“…Although base editors are useful tools for precise genome editing, current base editors can only convert either adenines or cytosines. We developed a dual…”
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Increasing the efficiency and targeting range of cytidine base editors through fusion of a single-stranded DNA-binding protein domain by Zhang, Xiaohui, Chen, Liang, Zhu, Biyun, Wang, Liren, Chen, Caiyu, Hong, Mengjia, Huang, Yifan, Li, Huiying, Han, Honghui, Cai, Bailian, Yu, Weishi, Yin, Shuming, Yang, Lei, Yang, Zuozhen, Liu, Meizhen, Zhang, Ying, Mao, Zhiyong, Wu, Yuxuan, Liu, Mingyao, Li, Dali

“…Cytidine base editors are powerful genetic tools that catalyse cytidine to thymidine conversion at specific genomic loci, and further improvement of the…”
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Reactivation of γ-globin expression through Cas9 or base editor to treat β-hemoglobinopathies by Wang, Liren, Li, Linxi, Ma, Yanlin, Hu, Handan, Li, Qi, Yang, Yang, Liu, Wenbang, Yin, Shuming, Li, Wei, Fu, Bin, Kurita, Ryo, Nakamura, Yukio, Liu, Mingyao, Lai, Yongrong, Li, Dali

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Cas9-nickase–mediated genome editing corrects hereditary tyrosinemia in rats by Shao, Yanjiao, Wang, Liren, Guo, Nana, Wang, Shengfei, Yang, Lei, Li, Yajing, Wang, Mingsong, Yin, Shuming, Han, Honghui, Zeng, Li, Zhang, Ludi, Hui, Lijian, Ding, Qiurong, Zhang, Jiqin, Geng, Hongquan, Liu, Mingyao, Li, Dali

“…Hereditary tyrosinemia type I (HTI) is a metabolic genetic disorder caused by mutation of fumarylacetoacetate hydrolase (FAH). Because of the accumulation of…”
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Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants by Yang, Lei, Zhang, Xiaohui, Wang, Liren, Yin, Shuming, Zhu, Biyun, Xie, Ling, Duan, Qiuhui, Hu, Huiqiong, Zheng, Rui, Wei, Yu, Peng, Liangyue, Han, Honghui, Zhang, Jiqin, Qiu, Wenjuan, Geng, Hongquan, Siwko, Stefan, Zhang, Xueli, Liu, Mingyao, Li, Dali

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Enhanced genome editing to ameliorate a genetic metabolic liver disease through co-delivery of adeno-associated virus receptor by Yin, Shuming, Ma, Lie, Shao, Tingting, Zhang, Mei, Guan, Yuting, Wang, Liren, Hu, Yaqiang, Chen, Xi, Han, Honghui, Shen, Nan, Qiu, Wenjuan, Geng, Hongquan, Yu, Yongguo, Li, Shichang, Yu, Weishi, Liu, Mingyao, Li, Dali

“…Genome editing through adeno-associated viral (AAV) vectors is a promising gene therapy strategy for various diseases, especially genetic disorders. However,…”
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Sex‐specific differences in blood lipids and lipid ratios in type 2 diabetic foot patients by Yin, Shuming, Zhao, Puqing, Ai, Zisheng, Deng, Bing, Jia, Wei, Wang, Huan, Zheng, Jiaqi

“…ABSTRACT Aims/Introduction Few people have reported whether there are sex differences in blood lipids and lipid ratios in type 2 diabetic foot (T2DF) patients…”
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Long-term effects and benefits of Helicobacter pylori eradication on the gastric mucosa in older individuals by Chen, Jie, Zhang, Gansheng, Qin, Jian, Huang, Yiqin, Wang, Yu, Li, Zhongkuo, Ji, Danian, Xiao, Li, Yin, Shuming, Bao, Zhijun

“…Background: The current international consensus report indicated that all Helicobacter pylori (H. pylori)-positive patients should be treated. This study aimed…”
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Optimization of Application Conditions of Drag Reduction Agent in Product Oil Pipelines by Dai, Xiaodong, Liu, Cuiwei, Zhao, Jishi, Li, Lei, Yin, Shuming, Liu, Huanrong

“…Drag reduction performance was studied with a rotating disk instrument in the laboratory, and experiments show that there is an initial rapid growth stage and…”
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Correction to: Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants by Yang, Lei, Zhang, Xiaohui, Wang, Liren, Yin, Shuming, Zhu, Biyun, Xie, Ling, Duan, Qiuhui, Hu, Huiqiong, Zheng, Rui, Wei, Yu, Peng, Liangyue, Han, Honghui, Zhang, Jiqin, Qiu, Wenjuan, Geng, Hongquan, Siwko, Stefan, Zhang, Xueli, Liu, Mingyao, Li, Dali

“…In the original publication the grant number is incorrectly published. The correct grant number should be read as “17140901600”. The corrected contents are…”
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EBSD Study on Deformation Twinning in AZ31 Magnesium Alloy During Quasi-in-Situ Compression by Yang, H. J., Yin, S. M., Huang, C. X., Zhang, Z. F., Wu, S. D., Li, S. X., Liu, Y. D.

“…In this paper, the authors use the electron back‐scatter diffraction (EBSD) technique to study the evolution of texture and microstructure during the…”
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Phylogeographic analysis of the fir species in southern China suggests complex origin and genetic admixture by Peng, Yanling, Yin, Shuming, Wang, Jing, Tian, Bin, Ren, Guangpeng, Guo, Qiuhong, Liu, Jianquan

“…Context Fir species are mainly distributed across the high latitudes, preferring cold climates. The phylogeographic origins of those subtropical fir species…”
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An Arabidopsis ctpA homologue is involved in the repair of photosystem II under high light by Yin, ShuMing, Sun, XuWu, Zhang, LiXin

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Experimental research on the characteristics of drag reduction and mechanical degradation of polyethylene oxide solution by Dai, Xiaodong, Li, Bing, Li, Lei, Yin, Shuming, Wang, Tao

“…Polymer drag reduction agents are easy to degrade during application. The drag reduction and mechanical degradation characteristics of polyethylene oxide were…”
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Engineering of efficiency-enhanced Cas9 and base editors with improved gene therapy efficacies by Yin, Shuming, Zhang, Mei, Liu, Yang, Sun, Xiaoyue, Guan, Yuting, Chen, Xi, Yang, Lei, Huo, Yanan, Yang, Jing, Zhang, Xiaohui, Han, Honghui, Zhang, Jiqin, Xiao, Min-Min, Liu, Mingyao, Hu, Jiazhi, Wang, Liren, Li, Dali

“…Editing efficiency is pivotal for the efficacies of CRISPR-based gene therapies. We found that fusing an HMG-D domain to the N terminus of SpCas9 (named…”
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Amelioration of an Inherited Metabolic Liver Disease through Creation of a De Novo Start Codon by Cytidine Base Editing by Yang, Lei, Wang, Liren, Huo, Yanan, Chen, Xi, Yin, Shuming, Hu, Yaqiang, Zhang, Xiaohui, Zheng, Rui, Geng, Hongquan, Han, Honghui, Ma, Xueyun, Liu, Meizhen, Li, Haibo, Yu, Weishi, Liu, Mingyao, Wang, Jun, Li, Dali

“…Base editing technology efficiently generates nucleotide conversions without inducing excessive double-strand breaks (DSBs), which makes it a promising…”
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Engineering APOBEC3A deaminase for highly accurate and efficient base editing by Yang, Lei, Huo, Yanan, Wang, Man, Zhang, Dan, Zhang, Tianai, Wu, Hao, Rao, Xichen, Meng, Haowei, Yin, Shuming, Mei, Jiale, Zhang, Dexin, Chen, Xi, Lv, Jia, Liu, Meizhen, Cheng, Yiyun, Guan, Yuting, Feng, Bo, Song, Gaojie, Yi, Chengqi, Liu, Mingyao, Zeng, Fanyi, Wang, Liren, Li, Dali

“…Cytosine base editors (CBEs) are effective tools for introducing C-to-T base conversions, but their clinical applications are limited by off-target and…”
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Lipid nanoparticle-mediated base-editing of the Hao1 gene achieves sustainable primary hyperoxaluria type 1 therapy in rats by Zhang, Dexin, Zheng, Rui, Chen, Zhoutong, Wang, Liren, Chen, Xi, Yang, Lei, Huo, Yanan, Yin, Shuming, Zhang, Dan, Huang, Jiaxin, Cui, Xingang, Li, Dali, Geng, Hongquan

“…Primary hyperoxaluria type 1 (PH1) is a severe hereditary disease, leading to the accumulation of oxalate in multiple organs, particularly the kidney…”
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The drag reduction and degradation characteristics of poly [alpha] olefin in diesel via rotating disk apparatus by Dai, Xiaodong, Li, Lei, Yin, Shuming, Zhang, Guicai, Ge, Jijiang

“…Poly α olefin/diesel system was studied by experiments with a rotating disk apparatus, to investigated drag reduction and degradation behavior. Four different…”
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A de novo missense mutation in MPP2 confers an increased risk of Vogt–Koyanagi–Harada disease as shown by trio-based whole-exome sequencing by Liu, Xianyang, Meng, Jiayu, Liao, Xingyun, Liu, Yusen, Zhou, Qian, Xu, Zongren, Yin, Shuming, Cao, Qingfeng, Su, Guannan, He, Siyuan, Li, Wanqian, Wang, Xiaotang, Wang, Guoqing, Li, Dali, Yang, Peizeng, Hou, Shengping

“…Vogt–Koyanagi–Harada (VKH) disease is a leading cause of blindness in young and middle-aged people. However, the etiology of VKH disease remains unclear. Here,…”
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