Search Results - "Yin, Min Jean"

miR-122 regulates tumorigenesis in hepatocellular carcinoma by targeting AKT3 by Nassirpour, Rounak, Mehta, Pramod P, Yin, Min-Jean

“…MicroRNAs (miRNAs) have been implicated in the orchestration of diverse cellular processes including differentiation, proliferation, and apoptosis and are…”
Get full text

miR-221 promotes tumorigenesis in human triple negative breast cancer cells by Nassirpour, Rounak, Mehta, Pramod P, Baxi, Sangita M, Yin, Min-Jean

“…Patients with triple-negative breast cancers (TNBCs) typically have a poor prognosis. TNBCs are characterized by their resistance to apoptosis, aggressive…”
Get full text

Suppression of Heat Shock Protein 27 Using OGX-427 Induces Endoplasmic Reticulum Stress and Potentiates Heat Shock Protein 90 Inhibitors to Delay Castrate-resistant Prostate Cancer by Lamoureux, François, Thomas, Christian, Yin, Min-Jean, Fazli, Ladan, Zoubeidi, Amina, Gleave, Martin E

“…Abstract Background Although prostate cancer responds initially to androgen ablation therapies, progression to castration-resistant prostate cancer (CRPC)…”
Get full text

Clusterin Inhibition Using OGX-011 Synergistically Enhances Hsp90 Inhibitor Activity by Suppressing the Heat Shock Response in Castrate-Resistant Prostate Cancer by LAMOUREUX, Francois, THOMAS, Christian, YIN, Min-Jean, KURUMA, Hidetoshi, BERALDI, Eliana, FAZLI, Ladan, ZOUBEIDI, Amina, GLEAVE, Martin E

“…Small-molecule inhibitors of Hsp90 show promise in the treatment of castrate-resistant prostate cancer (CRPC); however, these inhibitors trigger a heat shock…”
Get full text

A Novel HSP90 Inhibitor Delays Castrate-Resistant Prostate Cancer without Altering Serum PSA Levels and Inhibits Osteoclastogenesis by LAMOUREUX, Francois, THOMAS, Christian, YIN, Min-Jean, KURUMA, Hidetoshi, FAZLI, Ladan, GLEAVE, Martin E, ZOUBEIDI, Amina

“…Prostate cancer responds initially to antiandrogen therapies; however, progression to castration-resistant disease frequently occurs. Therefore, there is an…”
Get full text

Linking Nek6 to p53-induced senescence by Yin, Min-Jean

“…Comment on: Jee HJ, et al. Cell Cycle 2010; 9:4703-10…”
Get full text

Targeting 3-phosphoinoside-dependent kinase-1 to inhibit insulin-like growth factor-I induced AKT and p70 S6 kinase activation in breast cancer cells by Baxi, Sangita M, Tan, Wei, Murphy, Sean T, Smeal, Tod, Yin, Min-Jean

“…Binding of IGF to IGF-IR activates PI3K to generate PIP3 which in turn recruits and activates proteins that contain a pleckstrin homology (PH) domain,…”
Get full text

Effective Targeting of Triple-Negative Breast Cancer Cells by PF-4942847, a Novel Oral Inhibitor of Hsp 90 by MEHTA, Pramod P, WHALEN, Pamela, BAXI, Sangita M, KUNG, Pei-Pei, YAMAZAKI, Shinji, YIN, Min-Jean

“…Triple-negative breast cancer (TNBC) patients have poor prognoses and survival outcomes such that the development of new targeted therapies is in strong…”
Get full text

Targeting the mTOR pathway in tumor malignancy by Cheng, Hengmiao, Walls, Marlena, Baxi, Sangita M, Yin, Min-Jean

“…The mammalian target of rapamycin (mTOR) plays a critical role in the regulation of cell growth, proliferation,and metabolism by integrating growth factor…”
Get more information

The Serine/Threonine Kinase Nek6 Is Required for Cell Cycle Progression through Mitosis by Yin, Min-Jean, Shao, Lihua, Voehringer, David, Smeal, Tod, Jallal, Bahija

“…The Aspergillus nidulans protein NIMA (never in mitosis, gene A) is a protein kinase required for the initiation of mitosis, whereas its inactivation is…”
Get full text

PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity by Yuan, Jing, Mehta, Pramod P, Yin, Min-Jean, Sun, Shaoxian, Zou, Aihua, Chen, Jeffrey, Rafidi, Kristina, Feng, Zheng, Nickel, Jeffrey, Engebretsen, Jon, Hallin, Jill, Blasina, Alessandra, Zhang, Eric, Nguyen, Leslie, Sun, Minghao, Vogt, Peter K, McHarg, Aileen, Cheng, Hengmiao, Christensen, James G, Kan, Julie L C, Bagrodia, Shubha

“…Deregulation of the phosphoinositide 3-kinase (PI3K) signaling pathway such as by PTEN loss or PIK3CA mutation occurs frequently in human cancer and…”
Get full text

Discovery of 1‑{(3R,4R)‑3-[({5-Chloro-2-[(1-methyl‑1H‑pyrazol-4-yl)amino]‑7H‑pyrrolo[2,3‑d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants by Cheng, Hengmiao, Nair, Sajiv K, Murray, Brion W, Almaden, Chau, Bailey, Simon, Baxi, Sangita, Behenna, Doug, Cho-Schultz, Sujin, Dalvie, Deepak, Dinh, Dac M, Edwards, Martin P, Feng, Jun Li, Ferre, Rose Ann, Gajiwala, Ketan S, Hemkens, Michelle D, Jackson-Fisher, Amy, Jalaie, Mehran, Johnson, Ted O, Kania, Robert S, Kephart, Susan, Lafontaine, Jennifer, Lunney, Beth, Liu, Kevin K.-C, Liu, Zhengyu, Matthews, Jean, Nagata, Asako, Niessen, Sherry, Ornelas, Martha A, Orr, Suvi T. M, Pairish, Mason, Planken, Simon, Ren, Shijian, Richter, Daniel, Ryan, Kevin, Sach, Neal, Shen, Hong, Smeal, Tod, Solowiej, Jim, Sutton, Scott, Tran, Khanh, Tseng, Elaine, Vernier, William, Walls, Marlena, Wang, Shuiwang, Weinrich, Scott L, Xin, Shuibo, Xu, Haiwei, Yin, Min-Jean, Zientek, Michael, Zhou, Ru, Kath, John C

“…First generation EGFR TKIs (gefitinib, erlotinib) provide significant clinical benefit for NSCLC cancer patients with oncogenic EGFR mutations. Ultimately,…”
Get full text

Differential Transcriptional Activation by Human T-Cell Leukemia Virus Type 1 Tax Mutants Is Mediated by Distinct Interactions with CREB Binding Protein and p300 by Bex, Françoise, Yin, Min-Jean, Burny, Arsène, Gaynor, Richard B.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Nek6 mediates human cancer cell transformation and is a potential cancer therapeutic target by Nassirpour, Rounak, Shao, Lihua, Flanagan, Peter, Abrams, Tinya, Jallal, Bahija, Smeal, Tod, Yin, Min-Jean

“…We investigated the role of Nek6, a member of the NIMA-related serine/threonine kinase family, in tumorigenesis. Transcript, protein, and kinase activity…”
Get full text

IκB Kinase α (IKKα) Regulation of IKKβ Kinase Activity by Yamamoto, Yumi, Yin, Min-Jean, Gaynor, Richard B.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β by Gaynor, Richard B, Yin, Min-Jean, Yamamoto, Yumi

“…NF-κB comprises a family of cellular transcription factors that are involved in the inducible expression of a variety of cellular genes that regulate the…”
Get full text

Retraction notice to “A novel class of specific Hsp90 small molecule inhibitors demonstrate in vitro and in vivo anti-tumor activity in human melanoma cells” by Mehta, Pramod P., Kung, Pei-Pei, Yamazaki, Shinji, Walls, Marlena, Shen, Andrea, Nguyen, Leslie, Gehring, Michael R., Los, Gerrit, Smeal, Tod, Yin, Min-Jean

Get full text

Targeting Small Cell Lung Cancer Harboring PIK3CA Mutation with a Selective Oral PI3K Inhibitor PF-4989216 by WALLS, Marlena, BAXI, Sangita M, YIN, Min-Jean, MEHTA, Pramod P, LIU, Kevin K.-C, JINJIANG ZHU, ESTRELLA, Heather, CHUNZE LI, ZIENTEK, Michael, QING ZONG, SMEAL, Tod

“…Constitutive activation of phosphoinositide 3-kinase (PI3K) occurs frequently in many human tumors via either gene mutation in the p110α catalytic subunit of…”
Get full text

Sulindac Inhibits Activation of the NF-κB Pathway by Yamamoto, Yumi, Yin, Min-Jean, Lin, Keng-Mean, Gaynor, Richard B.

“…Sulindac is a non-steroidal anti-inflammatory agent that is related both structurally and pharmacologically to indomethacin. In addition to its…”
Get full text

Dihydroxyphenylisoindoline Amides as Orally Bioavailable Inhibitors of the Heat Shock Protein 90 (Hsp90) Molecular Chaperone by Kung, Pei-Pei, Huang, Buwen, Zhang, Gang, Zhou, Joe Zhongxiang, Wang, Jeff, Digits, Jennifer A, Skaptason, Judith, Yamazaki, Shinji, Neul, David, Zientek, Michael, Elleraas, Jeff, Mehta, Pramod, Yin, Min-Jean, Hickey, Michael J, Gajiwala, Ketan S, Rodgers, Caroline, Davies, Jay F, Gehring, Michael R

“…The discovery and optimization of potency and metabolic stability of a novel class of dihyroxyphenylisoindoline amides as Hsp90 inhibitors are presented…”
Get full text