Search Results - "Yin, Lianhong"

MicroRNA-140-5p aggravates doxorubicin-induced cardiotoxicity by promoting myocardial oxidative stress via targeting Nrf2 and Sirt2 by Zhao, Lisha, Qi, Yan, Xu, Lina, Tao, Xufeng, Han, Xu, Yin, Lianhong, Peng, Jinyong

“…Clinical application of doxorubicin (DOX), an anthracycline antibiotic with potent anti- tumor effects, is limited because of its cardiotoxicity. However, its…”
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Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress by Zhao, Lisha, Tao, Xufeng, Qi, Yan, Xu, Lina, Yin, Lianhong, Peng, Jinyong

“…Clinical application of doxorubicin (DOX) is limited because of its cardiotoxicity. Thus, exploration of effective lead compounds against DOX-induced…”
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Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-κB signaling pathway by Liu, Min, Xu, Youwei, Han, Xu, Yin, Lianhong, Xu, Lina, Qi, Yan, Zhao, Yanyan, Liu, Kexin, Peng, Jinyong

“…The present work aimed to investigate the activities and underlying mechanisms of dioscin against alcoholic liver fibrosis (ALF). In vivo liver fibrosis in…”
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MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1 by Zhao, Xuerong, Jin, Yue, Li, Lei, Xu, Lina, Tang, Zeyao, Qi, Yan, Yin, Lianhong, Peng, Jinyong

“…[Display omitted] As one classic anticancer drug, clinical application of Doxorubicin (Dox) is limited due to its side effects. In our previous work, we have…”
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Dioscin alleviates Alzheimer's disease through regulating RAGE/NOX4 mediated oxidative stress and inflammation by Guan, Linshu, Mao, Zhang, Yang, Sen, Wu, Guanlin, Chen, Yurong, Yin, Lianhong, Qi, Yan, Han, Lan, Xu, Lina

“…Alzheimer's disease (AD) is a neurodegenerative disease with amyloid beta (Aβ) deposition and intracellular neurofibrillary tangles (NFTs) as its…”
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Potent effects of dioscin against obesity in mice by Liu, Min, Xu, Lina, Yin, Lianhong, Qi, Yan, Xu, Youwei, Han, Xu, Zhao, Yanyan, Sun, Huijun, Yao, Jihong, Lin, Yuan, Liu, Kexin, Peng, Jinyong

“…The mechanisms of the natural product dioscin against non-alcoholic fatty liver disease (NAFLD) are unclear. Thus, the purpose of the present study was to…”
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Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo by Zhao, Xiaoming, Cong, Xiaonan, Zheng, Lingli, Xu, Lina, Yin, Lianhong, Peng, Jinyong

“…► The protective effect of dioscin against APAP-induced liver damage was investigated. ► Dioscin shows remarkable protective effect against the damage in vitro…”
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Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation by Qiao, Yujie, Xu, Lina, Tao, Xufeng, Yin, Lianhong, Qi, Yan, Xu, Youwei, Han, Xu, Tang, Zeyao, Ma, Xiaodong, Liu, Kexin, Peng, Jinyong

“…[Display omitted] •Dioscin showed protective effect against fructose-induced kidney injury in rats.•Dioscin improved oxidative damage and renal fibrosis caused…”
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Protective Effect of the Total Flavonoids from Rosa laevigata Michx Fruit on Renal Ischemia-Reperfusion Injury through Suppression of Oxidative Stress and Inflammation by Zhao, Lisha, Xu, Lina, Tao, Xufeng, Han, Xu, Yin, Lianhong, Qi, Yan, Peng, Jinyong

“…Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI). Our previous studies have shown that the total flavonoids (TFs) from…”
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Potent effects of dioscin against liver fibrosis by Zhang, Xiaoling, Han, Xu, Yin, Lianhong, Xu, Lina, Qi, Yan, Xu, Youwei, Sun, Huijun, Lin, Yuan, Liu, Kexin, Peng, Jinyong

“…We previously reported the promising effects of dioscin against liver injury, but its effect on liver fibrosis remains unknown. The present work investigated…”
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FABP4 contributes to renal interstitial fibrosis via mediating inflammation and lipid metabolism by Qiao, Yujie, Liu, Liping, Yin, Lianhong, Xu, Lina, Tang, Zeyao, Qi, Yan, Mao, Zhang, Zhao, Yanyan, Ma, Xiaodong, Peng, Jinyong

“…Fatty acid binding protein 4 (FABP4), a subtype of fatty acid-binding protein family, shows critical roles in metabolism and inflammation. However, its roles…”
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Dioscin Attenuates Hepatic Ischemia-Reperfusion Injury in Rats Through Inhibition of Oxidative-Nitrative Stress, Inflammation and Apoptosis by Tao, Xufeng, Wan, Xianyao, Xu, Youwei, Xu, Lina, Qi, Yan, Yin, Lianhong, Han, Xu, Lin, Yuan, Peng, Jinyong

“…BACKGROUNDDioscin shows potent effects against liver damage in our previous studies; however, the action of it on hepatic ischemia-reperfusion (I/R) injury is…”
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TMT-based proteomics reveals methylprotodioscin alleviates oxidative stress and inflammation via COX6C in myocardial infraction by Xu, Zhihui, Song, Tingyu, Yang, Xiufang, Cong, Linhao, Yin, Lianhong, Xu, Youwei, Han, Xu, Gao, Meng, Xu, Lina

“…The effect of methylprotodioscin (MPD), a steroidal saponin obtained from medicinal plants, on myocardial infarction (MI) remains elusive. In this study, HL-1…”
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Effects of flavonoids from Rosa laevigata Michx fruit against high-fat diet-induced non-alcoholic fatty liver disease in rats by Zhang, Shuai, Zheng, Lingli, Dong, Deshi, Xu, Lina, Yin, Lianhong, Qi, Yan, Han, Xu, Lin, Yuan, Liu, Kexin, Peng, Jinyong

“…•The TFs showed excellent effect against NAFLD in rats.•The TFs inhibited hepatic lipid accumulation.•The TFs prevented mitochondrial membrane potential…”
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Corrigendum to “Dioscin reduces ovariectomy-induced bone loss by enhancing osteoblastogenesis and inhibiting osteoclastogenesis” [Pharm. Res. 108 (2016) 90–101] by Tao, Xufeng, Qi, Yan, Xu, Lina, Yin, Lianhong, Han, Xu, Xu, Youwei, Wang, Changyuan, Sun, Huijun, Peng, Jinyong

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Protection of the flavonoid fraction from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice by Zhang, Shuai, Lu, Binan, Han, Xu, Xu, Lina, Qi, Yan, Yin, Lianhong, Xu, Youwei, Zhao, Yanyan, Liu, Kexin, Peng, Jinyong

“…► The total flavonoids (TFs) showed obvious preventing effects on CCl4-induced acute liver injury in mice. ► TFs inhibited the production of free radicals. ►…”
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Naringin prevents carbon tetrachloride-induced acute liver injury in mice by Dong, Deshi, Xu, Lina, Yin, Lianhong, Qi, Yan, Peng, Jinyong

“…•Nar showed protective effect against CCl4-induced acute liver injury in mice.•Nar down-regulated CYP2E1 expression.•Nar reduced oxidative stress.•Nar…”
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circMIRIAF aggravates myocardial ischemia-reperfusion injury via targeting miR-544/WDR12 axis by Yin, Lianhong, Li, Lili, Gao, Meng, Qi, Yan, Xu, Lina, Peng, Jinyong

“…Exploring and discovering novel circRNAs is one of the ways to develop innovative drugs for the diagnosis and treatment of myocardial ischemia-reperfusion…”
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Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo by Zheng, Lingli, Yin, Lianhong, Xu, Lina, Qi, Yan, Li, Hua, Xu, Youwei, Han, Xu, Liu, Kexin, Peng, Jinyong

“…Our previous works showed that dioscin, a natural product, could protect liver from acute liver damages induced by dimethylnitrosamine, ethanol, carbon…”
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Neuroprotective Effect of Dioscin on the Aging Brain by Qi, Yan, Li, Ruomiao, Xu, Lina, Yin, Lianhong, Xu, Youwei, Han, Xu, Peng, Jinyong

“…Our previous works have shown that dioscin, a natural product, has various pharmacological activities, however, its role in brain aging has not been reported…”
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