Search Results - "Yin, Hong Z"
-
1
VCP/p97 inhibitor CB-5083 modulates muscle pathology in a mouse model of VCP inclusion body myopathy
Published in Journal of translational medicine (08-01-2022)“…Pathogenic gain of function variants in Valosin-containing protein (VCP) cause a unique disease characterized by inclusion body myopathy with early-onset Paget…”
Get full text
Journal Article -
2
Intrathecal infusion of BMAA induces selective motor neuron damage and astrogliosis in the ventral horn of the spinal cord
Published in Experimental neurology (01-11-2014)“…The neurotoxin beta-N-methylamino-l-alanine (BMAA) was first identified as a “toxin of interest” in regard to the amyotrophic lateral sclerosis–Parkinsonism…”
Get full text
Journal Article -
3
The homozygote VCP(R¹⁵⁵H/R¹⁵⁵H) mouse model exhibits accelerated human VCP-associated disease pathology
Published in PloS one (2012)“…Valosin containing protein (VCP) mutations are the cause of hereditary inclusion body myopathy, Paget's disease of bone, frontotemporal dementia (IBMPFD). VCP…”
Get full text
Journal Article -
4
Mechanisms of seizure-induced ‘transcriptional channelopathy’ of hyperpolarization-activated cyclic nucleotide gated (HCN) channels
Published in Neurobiology of disease (01-02-2008)“…Abstract Epilepsy may result from abnormal function of ion channels, such as those caused by genetic mutations. Recently, pathological alterations of the…”
Get full text
Journal Article -
5
Disruption of Glial Glutamate Transport by Reactive Oxygen Species Produced in Motor Neurons
Published in The Journal of neuroscience (01-04-2003)“…Observations of elevated CSF glutamate in amyotrophic lateral sclerosis (ALS), together with findings that motor neurons are selectively vulnerable to…”
Get full text
Journal Article -
6
Preferential Zn2+Influx through Ca2+-permeable AMPA/Kainate Channels Triggers Prolonged Mitochondrial Superoxide Production
Published in Proceedings of the National Academy of Sciences - PNAS (02-03-1999)“…Synaptically released Zn2+can enter and cause injury to postsynaptic neurons. Microfluorimetric studies using the Zn2+-sensitive probe, Newport green, examined…”
Get full text
Journal Article -
7
Blockade of Ca2+-Permeable AMPA/Kainate Channels Decreases Oxygen-Glucose Deprivation-Induced Zn2+ Accumulation and Neuronal Loss in Hippocampal Pyramidal Neurons
Published in The Journal of neuroscience (15-02-2002)“…Synaptic release of Zn2+ and its translocation into postsynaptic neurons probably contribute to neuronal injury after ischemia or epilepsy. Studies in cultured…”
Get full text
Journal Article -
8
Mitochondrial Zn2+ Accumulation: A Potential Trigger of Hippocampal Ischemic Injury
Published in The Neuroscientist (01-04-2019)“…Ischemic stroke is a major cause of death and disabilities worldwide, and it has been long hoped that improved understanding of relevant injury mechanisms…”
Get full text
Book Review Journal Article -
9
Blocking Mitochondrial Zn2+ Accumulation after Ischemia Reduces Mitochondrial Dysfunction and Neuronal Injury
Published in The Journal of neuroscience (29-06-2022)“…Zn2+ is an important contributor to ischemic brain injury, and recent studies support the hypothesis that mitochondria are key sites of its injurious effects…”
Get full text
Journal Article -
10
Blocking Mitochondrial Zn 2+ Accumulation after Ischemia Reduces Mitochondrial Dysfunction and Neuronal Injury
Published in The Journal of neuroscience (29-06-2022)“…Zn is an important contributor to ischemic brain injury, and recent studies support the hypothesis that mitochondria are key sites of its injurious effects. In…”
Get full text
Journal Article -
11
Rapid Intramitochondrial Zn2+ Accumulation in CA1 Hippocampal Pyramidal Neurons After Transient Global Ischemia: A Possible Contributor to Mitochondrial Disruption and Cell Death
Published in Journal of neuropathology and experimental neurology (01-07-2019)“…Mitochondrial Zn2+ accumulation, particularly in CA1 neurons, occurs after ischemia and likely contributes to mitochondrial dysfunction and subsequent…”
Get full text
Journal Article -
12
Mitochondrial Zn 2+ Accumulation: A Potential Trigger of Hippocampal Ischemic Injury
Published in The Neuroscientist (Baltimore, Md.) (01-04-2019)“…Ischemic stroke is a major cause of death and disabilities worldwide, and it has been long hoped that improved understanding of relevant injury mechanisms…”
Get full text
Journal Article -
13
TNF-α triggers rapid membrane insertion of Ca(2+) permeable AMPA receptors into adult motor neurons and enhances their susceptibility to slow excitotoxic injury
Published in Experimental neurology (01-12-2012)“…Excitotoxicity (caused by over-activation of glutamate receptors) and inflammation both contribute to motor neuron (MN) damage in amyotrophic lateral sclerosis…”
Get full text
Journal Article -
14
The Homozygote VCPR155H/R155H Mouse Model Exhibits Accelerated Human VCP-Associated Disease Pathology
Published in PloS one (28-09-2012)“…Valosin containing protein (VCP) mutations are the cause of hereditary inclusion body myopathy, Paget's disease of bone, frontotemporal dementia (IBMPFD). VCP…”
Get full text
Journal Article -
15
Differential Vulnerability of CA1 versus CA3 Pyramidal Neurons After Ischemia: Possible Relationship to Sources of Zn2+ Accumulation and Its Entry into and Prolonged Effects on Mitochondria
Published in The Journal of neuroscience (18-01-2017)“…Excitotoxic mechanisms contribute to the degeneration of hippocampal pyramidal neurons after recurrent seizures and brain ischemia. However, susceptibility…”
Get full text
Journal Article -
16
A progressive translational mouse model of human valosin-containing protein disease: the VCP(R155H/+) mouse
Published in Muscle & nerve (01-02-2013)“…Mutations in the valosin-containing protein (VCP) gene cause hereditary inclusion body myopathy (IBM) associated with Paget disease of bone (PDB), and…”
Get full text
Journal Article -
17
Marked synergism between mutant SOD1 and glutamate transport inhibition in the induction of motor neuronal degeneration in spinal cord slice cultures
Published in Brain research (11-04-2012)“…Abstract Loss of astrocytic glutamate transport capacity in ALS spinal cord supports an excitotoxic contribution to motor neuron (MN) damage in the disease,…”
Get full text
Journal Article -
18
A progressive translational mouse model of human valosin-containing protein disease: The VCPR155H/+ mouse
Published in Muscle & nerve (01-02-2013)“…Introduction: Mutations in the valosin‐containing protein (VCP) gene cause hereditary inclusion body myopathy (IBM) associated with Paget disease of bone…”
Get full text
Journal Article -
19
Intrathecal infusion of a Ca(2+)-permeable AMPA channel blocker slows loss of both motor neurons and of the astrocyte glutamate transporter, GLT-1 in a mutant SOD1 rat model of ALS
Published in Experimental neurology (01-10-2007)“…Elevated extracellular glutamate, resulting from a loss of astrocytic glutamate transport capacity, may contribute to excitotoxic motor neuron (MN) damage in…”
Get full text
Journal Article -
20
AMPA Exposures Induce Mitochondrial Ca2+ Overload and ROS Generation in Spinal Motor Neurons In Vitro
Published in The Journal of neuroscience (01-01-2000)“…The reason for the selective vulnerability of motor neurons in amyotrophic lateral sclerosis (ALS) is primarily unknown. A possible factor is the expression by…”
Get full text
Journal Article