Search Results - "Yin, Hanwei"

Clinical application of thioredoxin reductase as a novel biomarker in liver cancer by Wu, Xuping, Wang, Qi, Lu, Yousheng, Zhang, Jinye, Yin, Hanwei, Yi, Yongxiang

“…Hepatic cancer is often amenable to surgery, including percutaneous ablation, trans-arterial chemoembolization. However, in metastatic cases, surgery is often…”
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TrxR/Trx inhibitor butaselen ameliorates pulmonary fibrosis by suppressing NF-κB/TGF-β1/Smads signaling by Chen, Yifan, Yin, Hanwei, Sun, Jing, Zhang, Guozhou, Zhang, Ying, Zeng, Huihui

“…Pulmonary fibrosis is highly lethal with limited treatments. Butaselen (BS) is an inhibitor of thioredoxin reductase (TrxR)/thioredoxin (Trx) with anti-tumor…”
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Thioredoxin Reductase as a Novel and Efficient Plasma Biomarker for the Detection of Non-Small Cell Lung Cancer: a Large-scale, Multicenter study by Ye, Suofu, Chen, Xiaofeng, Yao, Yi, Li, Yueqin, Sun, Ruoxuan, Zeng, Huihui, Shu, Yongqian, Yin, Hanwei

“…There is an increased demand for efficient biomarkers for the diagnosis of non-small cell lung cancer (NSCLC). This study aimed to evaluate plasma levels of…”
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Absorption, Distribution, Metabolism, and Excretion of [ 14 C]BS1801, a Selenium-Containing Drug Candidate, in Rats by Yang, Cheng, Xue, Mingzhen, He, Yifei, Yin, Hanwei, Yang, Chen, Zhong, Dafang, Zeng, Huihui, Zheng, Yuandong, Diao, Xingxing

“…BS1801 is a selenium-containing drug candidate with potential for treating liver and lung fibrosis. To fully elucidate the biotransformation of BS1801 in…”
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Butaselen prevents hepatocarcinogenesis and progression through inhibiting thioredoxin reductase activity by Zheng, Xiaoqing, Ma, Weiwei, Sun, Ruoxuan, Yin, Hanwei, Lin, Fei, Liu, Yuxi, Xu, Wei, Zeng, Huihui

“…Hepatocellular carcinoma (HCC) accounts for most of primary liver cancer, of which five-year survival rate remains low and chemoprevention has become a…”
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A Transcriptional Regulatory Role of the THAP11–HCF-1 Complex in Colon Cancer Cell Function by Parker, J. Brandon, Palchaudhuri, Santanu, Yin, Hanwei, Wei, Jianjun, Chakravarti, Debabrata

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Host Cell Factor-1 Recruitment to E2F-Bound and Cell-Cycle-Control Genes Is Mediated by THAP11 and ZNF143 by Parker, J. Brandon, Yin, Hanwei, Vinckevicius, Aurimas, Chakravarti, Debabrata

“…Host cell factor-1 (HCF-1) is a metazoan transcriptional coregulator essential for cell-cycle progression and cell proliferation. Current models suggest a…”
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Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA by Chen, Julia Ling-Yu, Merl, Daniel, Peterson, Christopher W, Wu, Jianli, Liu, Patrick Yantyng, Yin, Hanwei, Muoio, Deborah M, Ayer, Don E, West, Mike, Chi, Jen-Tsan

“…Although lactic acidosis is a prominent feature of solid tumors, we still have limited understanding of the mechanisms by which lactic acidosis influences…”
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Therapeutic Effects of an Inhibitor of Thioredoxin Reductase on Liver Fibrosis by Inhibiting the Transforming Growth Factor-β1/Smads Pathway by Jiao, Wenxuan, Bai, Man, Yin, Hanwei, Liu, Jiayi, Sun, Jing, Su, Xiaoxia, Zeng, Huihui, Wen, Jinhua

“…Liver fibrosis is an important stage in the progression of liver injury into cirrhosis or even liver cancer. Hepatic stellate cells (HSCs) are induced by…”
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Corrigendum to ‘Butaselen prevents hepatocarcinogenesis and progression through inhibiting thioredoxin reductase activity’ [Redox Biol. 14 (2018) 237–249] by Zheng, Xiaoqing, Ma, Weiwei, Sun, Ruoxuan, Yin, Hanwei, Lin, Fei, Liu, Yuxi, Xu, Wei, Zeng, Huihui

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Expression Profiling of Nuclear Receptors Identifies Key Roles of NR4A Subfamily in Uterine Fibroids by Yin, Hanwei, Lo, Jay H, Kim, Ji-Young, Marsh, Erica E, Kim, J. Julie, Ghosh, Asish K, Bulun, Serdar, Chakravarti, Debabrata

“…Uterine fibroids (UFs), also known as uterine leiomyomas, are benign, fibrotic smooth muscle tumors. Although the GnRH analog leuprolide acetate that…”
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A Novel TrxR1 Inhibitor Regulates NK and CD8+ T Cell Infiltration and Cytotoxicity, Enhancing the Efficacy of Anti-PD-1 Immunotherapy against Hepatocarcinoma by Su, Xiaoxia, Yin, Hanwei, Bai, Man, Liu, Jiayi, Liu, Runyu, Zeng, Huihui, Wen, Jinhua

“…Hepatocellular carcinoma (HCC) has the third highest cancer-related mortality rate globally. The immunosuppressive microenvironment of HCC limits effective…”
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Quantification of the major circulating metabolite of BS1801, an ebselen analog, in human plasma by Tian, Qianqian, Jiang, Jinfang, Yin, Hanwei, Ma, Jiao, Deng, Guozhen, Zhou, Jialan, Zhong, Dafang

“…BS1801 contains two selenium atoms in its structure, which is a specific inhibitor of thioredoxin reductase intended to treat fibrotic interstitial pneumonia…”
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Role of thioredoxin reductase 1 in dysplastic transformation of human breast epithelial cells triggered by chronic oxidative stress by Dong, Chaoran, Zhang, Lei, Sun, Ruoxuan, Liu, Jianying, Yin, Hanwei, Li, Xiaoxiao, Zheng, Xiaoqing, Zeng, Huihui

“…Thioredoxin reductase 1 (TrxR1) is a pivotal intracellular redox sensor and antioxidant enzyme. On the other hand, overexpression of TrxR1 is closely…”
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Absorption, Distribution, Metabolism, and Excretion of [[sup.14]C]BS1801, a Selenium-Containing Drug Candidate, in Rats by Yang, Cheng, Xue, Mingzhen, He, Yifei, Yin, Hanwei, Yang, Chen, Zhong, Dafang, Zeng, Huihui, Zheng, Yuandong, Diao, Xingxing

“…BS1801 is a selenium-containing drug candidate with potential for treating liver and lung fibrosis. To fully elucidate the biotransformation of BS1801 in…”
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Plasma activity of Thioredoxin Reductase as a Novel Biomarker in Gastric Cancer by Peng, Wei, Zhou, Zhaofei, Zhong, Yuejiao, Sun, Yan, Wang, Yajing, Zhu, Zili, Jiao, Wenxuan, Bai, Man, Sun, Jing, Lu, Jianwei, Yin, Hanwei

“…Gastric cancer (GC) is one of the leading malignancies around the world. Identification of novel and efficient biomarkers for GC diagnosis and evaluation of…”
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Synergism between thioredoxin reductase inhibitor ethaselen and sodium selenite in inhibiting proliferation and inducing death of human non-small cell lung cancer cells by Zheng, Xiaoqing, Xu, Wei, Sun, Ruoxuan, Yin, Hanwei, Dong, Chaoran, Zeng, Huihui

“…New effective treatment for human non-small cell lung cancer (NSCLC) is needed. The thioredoxin (Trx) system composes of thioredoxin reductase (TrxR), Trx and…”
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Ethaselen: a potent mammalian thioredoxin reductase 1 inhibitor and novel organoselenium anticancer agent by Wang, Lihui, Yang, Zhiyu, Fu, Jianing, Yin, Hanwei, Xiong, Kun, Tan, Qiang, Jin, Hongwei, Li, Jing, Wang, Tianyu, Tang, Wanchen, Yin, Jin, Cai, Gaoxiong, Liu, Mi, Kehr, Sebastian, Becker, Katja, Zeng, Huihui

“…Mammalian thioredoxin reductase 1 (TrxR1) is considered to be an important anticancer drug target and to be involved in both carcinogenesis and cancer…”
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Investigating the Metabolic Mechanisms of Butaselen, An Ebselen Analog by Tian, Qianqian, Jiang, Jinfang, Yin, Hanwei, Zhang, Yifan, Li, Yilin, Wu, Ping, Peng, Chao, Wang, Zhijie, Zhou, Jialan, Zeng, Huihui, Zhong, Dafang

“…Butaselen is an ebselen analog that is under clinical trials for treating hepatic and pulmonary fibrosis. Our previous studies showed that butaselen is mainly…”
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Serum thioredoxin reductase 1 as a diagnostic marker for non-small cell lung cancer by Kang, Xiaozheng, Dong, Chaoran, Shen, Bocun, Yin, Hanwei, Xu, Guobing, Chen, Ke-Neng, Zeng, Huihui

“…Abstract only e23069 Background: Non-invasive diagnostic markers for patients with suspicious non-small cell lung cancer (NSCLC) may provide needed guidance on…”
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