Search Results - "Yin, Guangliang"
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Identification of genomic alterations in oesophageal squamous cell cancer
Published in Nature (London) (01-05-2014)“…Using whole-genome and whole-exome sequencing, this study identifies eight significantly mutated genes in oesophageal squamous cell cancer, including two…”
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2
Immature truncated O-glycophenotype of cancer directly induces oncogenic features
Published in Proceedings of the National Academy of Sciences - PNAS (30-09-2014)“…Aberrant expression of immature truncated O-glycans is a characteristic feature observed on virtually all epithelial cancer cells, and a very high frequency is…”
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3
Genomic heterogeneity of multiple synchronous lung cancer
Published in Nature communications (21-10-2016)“…Multiple synchronous lung cancers (MSLCs) present a clinical dilemma as to whether individual tumours represent intrapulmonary metastases or independent…”
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Integrative genomic and functional analysis of human oral squamous cell carcinoma cell lines reveals synergistic effects of FAT1 and CASP8 inactivation
Published in Cancer letters (01-12-2016)“…Abstract Oral squamous cell carcinoma (OSCC) is genetically highly heterogeneous, which contributes to the challenges of treatment. To create an in vitro model…”
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Vibrio anguillarum Is Genetically and Phenotypically Unaffected by Long-Term Continuous Exposure to the Antibacterial Compound Tropodithietic Acid
Published in Applied and environmental microbiology (01-08-2016)“…Minimizing the use of antibiotics in the food production chain is essential for limiting the development and spread of antibiotic-resistant bacteria. One…”
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DNA methylation in liver tumorigenesis in fish from the environment
Published in Epigenetics (01-11-2011)“…The link between environment, alteration in DNA methylation and cancer has been well established in humans; yet, it is under-studied in unsequenced non-model…”
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A systematic analysis on DNA methylation and the expression of both mRNA and microRNA in bladder cancer
Published in PloS one (30-11-2011)“…DNA methylation aberration and microRNA (miRNA) deregulation have been observed in many types of cancers. A systematic study of methylome and transcriptome in…”
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Genome-wide mapping of DNA methylation in chicken
Published in PloS one (05-05-2011)“…Cytosine DNA methylation is an important epigenetic modification termed as the fifth base that functions in diverse processes. Till now, the genome-wide DNA…”
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An improved method for genome wide DNA methylation profiling correlated to transcription and genomic instability in two breast cancer cell lines
Published in BMC genomics (13-05-2009)“…DNA methylation is a widely studied epigenetic mechanism known to correlate with gene repression and genomic stability. Development of sensitive methods for…”
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Whole-genome DNA methylation in skin lesions from patients with psoriasis vulgaris
Published in Journal of autoimmunity (01-03-2013)“…Abstract Psoriasis, a chronic inflammatory skin disorder, is characterized by aberrant keratinocyte proliferation and differentiation in the epidermis…”
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An atlas of DNA methylomes in porcine adipose and muscle tissues
Published in Nature communications (22-05-2012)“…It is evident that epigenetic factors, especially DNA methylation, have essential roles in obesity development. Here, using pig as a model, we investigate the…”
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C14orf93 (RTFC) is identified as a novel susceptibility gene for familial nonmedullary thyroid cancer
Published in Biochemical and biophysical research communications (22-01-2017)“…The genetic causes for familial nonmedullary thyroid cancer (FNMTC) remain largely unknown. Through genetic linkage analysis and exome sequencing, C14orf93…”
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Integrative analyses of gene expression and DNA methylation profiles in breast cancer cell line models of tamoxifen-resistance indicate a potential role of cells with stem-like properties
Published in Breast cancer research : BCR (19-12-2013)“…Development of resistance to tamoxifen is an important clinical issue in the treatment of breast cancer. Tamoxifen resistance may be the result of acquisition…”
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Distinct epigenomes in CD4+ T cells of newborns, middle-ages and centenarians
Published in Scientific reports (05-12-2016)“…Age-related variations in genes and microRNAs expression and DNA methylation have been reported respectively; however, their interactions during aging are…”
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Whole exome sequencing of rare aggressive breast cancer histologies
Published in Breast cancer research and treatment (01-02-2016)“…Little is known about mutational landscape of rare breast cancer (BC) subtypes. The aim of the study was to apply next generation sequencing to three different…”
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Whole Exome Sequencing Identifies Frequent Somatic Mutations in Cell-Cell Adhesion Genes in Chinese Patients with Lung Squamous Cell Carcinoma
Published in Scientific reports (27-10-2015)“…Lung squamous cell carcinoma (SQCC) accounts for about 30% of all lung cancer cases. Understanding of mutational landscape for this subtype of lung cancer in…”
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Obesity is associated with depot-specific alterations in adipocyte DNA methylation and gene expression
Published in Adipocyte (03-04-2017)“…The present study aimed to identify genes exhibiting concomitant obesity-dependent changes in DNA methylation and gene expression in adipose tissues in the…”
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Analysis of a four generation family reveals the widespread sequence-dependent maintenance of allelic DNA methylation in somatic and germ cells
Published in Scientific reports (13-01-2016)“…Differential methylation of the homologous chromosomes, a well-known mechanism leading to genomic imprinting and X-chromosome inactivation, is widely reported…”
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Abstract 2982: Genome sequencing reveals the multicentric nature of multiple synchronous lung adenocarcinomas
Published in Cancer research (Chicago, Ill.) (01-08-2015)“…Abstract Background: Genomic heterogeneity of lung cancers from different patients has been well documented, reflecting distinct genetic background and…”
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20
Immature truncated O-glycophenotype of cancer directly induces oncogenic features
Published in Proceedings of the National Academy of Sciences - PNAS (30-09-2014)Get full text
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